{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T21:04:59Z","timestamp":1767474299887},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>McCune-Albright syndrome (MAS) is characterized by the triad of polyostotic bone fibrous dysplasia (PFD), endocrine disorders, and caf\u00e9-au-lait skin pigmentation. Ninety percent of MAS patients have fibrous dysplasia (FD) craniofacial lesions. Osteonecrosis of the jaw (ONJ) has been described as an adverse side effect of bisphosphonate therapy. The aim of the study was to investigate evidence of clinical and\/or radiological signs of ONJ in FD\/MAS pediatric patients due to bisphosphonate therapy and describe odontoiatric tools in this population.<\/jats:p><jats:p>Thirteen FD\/MAS patients were enrolled. All patients during pediatric age have been treated with pamidronate infusions. They underwent complete oral clinical examination. Ortopantomography and\/or CT were evaluated in all cases.<\/jats:p><jats:p>No patient developed ONJ. None of them showed radiological signs different from jaw FD. In spite of the low number of patients enrolled, results confirm that, in this population, ONJ can be ruled out as a chronic adverse side effect of bisphosphonate therapy.<\/jats:p>","DOI":"10.1515\/jpem-2015-0300","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T12:29:50Z","timestamp":1447417790000},"source":"Crossref","is-referenced-by-count":11,"title":["Odontoiatric perspectives and osteonecrosis of the jaw as a possible adverse effect of bisphosphonates therapy in fibrous dysplasia and McCune-Albright syndrome"],"prefix":"10.1515","volume":"29","author":[{"given":"Daniele","family":"Tessaris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Matarazzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Lala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Defabianis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref361","first-page":"170","article-title":"Oral manifestations of syndrome","volume":"17","author":"Aravinda","year":"2013","journal-title":"J Endocrinol Metab"},{"key":"ref331","article-title":"MT syndrome","volume":"19","author":"Dumitrescu","year":"2008","journal-title":"Orphanet J Rare Dis"},{"key":"ref271","first-page":"116","article-title":"SO MT Dental perspectives in fibrous dysplasia syndrome Oral Surg Oral Oral","author":"Akintoye","year":"2013","journal-title":"AM Med Pathol Oral Radiol"},{"key":"ref91","first-page":"1","article-title":"Monostotic fibrous dysplasia with dental anomalies Report of a case Oral Surg Oral Oral","author":"Glick","year":"1971","journal-title":"Catena Med"},{"key":"ref301","first-page":"583","article-title":"Study group for Gs alpha protein related diseases of the italian society for pediatric endocrinology and diabetes Bisphosphonate treatment of bone fibrous dysplasia in syndrome","volume":"19","author":"Lala","year":"2006","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref191","article-title":"MT syndrome","volume":"19","author":"Dumitrescu","year":"2008","journal-title":"Orphanet J Rare Dis"},{"key":"ref51","first-page":"561","article-title":"diagnosis in syndrome","volume":"19","author":"Defilippi","year":"2006","journal-title":"Image J Pediatr Endocrinol Metab"},{"key":"ref281","first-page":"1","article-title":"Monostotic fibrous dysplasia with dental anomalies Report of a case Oral Surg Oral Oral","author":"Glick","year":"1971","journal-title":"Catena Med"},{"key":"ref11","first-page":"279","article-title":"The syndrome","volume":"17","author":"Mauras","year":"1986","journal-title":"Acta Endocrinol"},{"key":"ref141","article-title":"MT syndrome","volume":"19","author":"Dumitrescu","year":"2008","journal-title":"Orphanet J Rare Dis"},{"key":"ref321","first-page":"515","article-title":"Bisphosphonates complication including osteonecrosis of the jaw","author":"Ruggiero","year":"2006","journal-title":"Hematology"},{"key":"ref31","first-page":"913","article-title":"de Impact of endocrine hyperfunction and phosphate wasting on bone in syndrome","volume":"15","author":"Lala","year":"2002","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref371","first-page":"275","article-title":"SO Dental characteristics of fibrous dysplasia syndrome Oral Surg Oral Oral","author":"Akintoye","year":"2003","journal-title":"Med Pathol Oral Radiol"},{"key":"ref71","first-page":"548","article-title":"Clinical and radiographic features of chronic monostotic fibrous dysplasia of the mandible","author":"Steven","year":"2004","journal-title":"J Can Dent Assoc"},{"key":"ref211","first-page":"123","article-title":"endocrine and nonendocrine manifestations of the syndrome associated with activating mutations of stimulatory protein","volume":"18","author":"Shenker","year":"1993","journal-title":"J Pediatr"},{"key":"ref311","article-title":"RE zoledronate induced avascular necrosis of the jaws : a growing epidemic Oral","author":"Marx","year":"2003"},{"key":"ref111","first-page":"583","article-title":"Study group for Gs alpha protein related diseases of the italian society for pediatric endocrinology and diabetes Bisphosphonate treatment of bone fibrous dysplasia in syndrome","volume":"19","author":"Lala","year":"2006","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref201","first-page":"279","article-title":"The syndrome","volume":"17","author":"Mauras","year":"1986","journal-title":"Acta Endocrinol"},{"key":"ref351","first-page":"134","article-title":"half - life of bisphosphonates","author":"Bartl","year":"2009","journal-title":"Med"},{"key":"ref261","first-page":"548","article-title":"Clinical and radiographic features of chronic monostotic fibrous dysplasia of the mandible","author":"Steven","year":"2004","journal-title":"J Can Dent Assoc"},{"key":"ref41","first-page":"401","article-title":"The pathology of fibrous dysplasia and the syndrome","volume":"11","author":"Riminucci","year":"2007","journal-title":"Rev"},{"key":"ref121","article-title":"RE zoledronate induced avascular necrosis of the jaws : a growing epidemic Oral","author":"Marx","year":"2003"},{"key":"ref161","first-page":"134","article-title":"half - life of bisphosphonates","author":"Bartl","year":"2009","journal-title":"Med"},{"key":"ref181","first-page":"275","article-title":"SO Dental characteristics of fibrous dysplasia syndrome Oral Surg Oral Oral","author":"Akintoye","year":"2003","journal-title":"Med Pathol Oral Radiol"},{"key":"ref231","first-page":"401","article-title":"The pathology of fibrous dysplasia and the syndrome","volume":"11","author":"Riminucci","year":"2007","journal-title":"Rev"},{"key":"ref221","first-page":"913","article-title":"de Impact of endocrine hyperfunction and phosphate wasting on bone in syndrome","volume":"15","author":"Lala","year":"2002","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref341","first-page":"318","article-title":"Osteochemonecrosis of the jaws due to bisphosphonate treatments Update","volume":"13","author":"G\u00f3mez Font","year":"2008","journal-title":"Med Oral Patol Oral"},{"key":"ref81","first-page":"116","article-title":"SO MT Dental perspectives in fibrous dysplasia syndrome Oral Surg Oral Oral","author":"Akintoye","year":"2013","journal-title":"AM Med Pathol Oral Radiol"},{"key":"ref171","first-page":"170","article-title":"Oral manifestations of syndrome","volume":"17","author":"Aravinda","year":"2013","journal-title":"J Endocrinol Metab"},{"key":"ref241","first-page":"561","article-title":"diagnosis in syndrome","volume":"19","author":"Defilippi","year":"2006","journal-title":"Image J Pediatr Endocrinol Metab"},{"key":"ref21","first-page":"123","article-title":"endocrine and nonendocrine manifestations of the syndrome associated with activating mutations of stimulatory protein","volume":"18","author":"Shenker","year":"1993","journal-title":"J Pediatr"},{"key":"ref291","first-page":"652","article-title":"Zins JE Fibrous dysplasia a case report","volume":"16","author":"Esposito","year":"1995"},{"key":"ref01","article-title":"MT syndrome","volume":"19","author":"Dumitrescu","year":"2008","journal-title":"Orphanet J Rare Dis"},{"key":"ref101","first-page":"652","article-title":"Zins JE Fibrous dysplasia a case report","volume":"16","author":"Esposito","year":"1995"},{"key":"ref131","first-page":"515","article-title":"Bisphosphonates complication including osteonecrosis of the jaw","author":"Ruggiero","year":"2006","journal-title":"Hematology"},{"key":"ref151","first-page":"318","article-title":"Osteochemonecrosis of the jaws due to bisphosphonate treatments Update","volume":"13","author":"G\u00f3mez Font","year":"2008","journal-title":"Med Oral Patol Oral"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2015-0300\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T01:39:51Z","timestamp":1619055591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2015-0300\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":36,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1515\/jpem-2015-0300","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1,1]]}}}