{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:15:17Z","timestamp":1777425317869,"version":"3.51.4"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p\/><jats:p>IGF-I and IGFBP-3 levels of 60 children (male n=38) were assessed in a retrospective cross-sectional setting.<\/jats:p><jats:p>Height\/weight was significant different [height z-score type 3 versus type 4: p=0.0011 and weight (p\u22640.0001)] between OI type 3 and 4. Mean IGF-I levels were in the lower normal range (mean\u00b1SD level 137.4\u00b1109.1 \u03bcg\/L). Mean IGFBP-3 measurements were in the normal range (mean\u00b1SD 3.105\u00b11.175 mg\/L). No significant differences between OI type 3 and 4 children have been observed (IGF-I: p=0.0906; IGFBP-3: p=0.2042).<\/jats:p><jats:p>Patients with different severities of OI have IGF-I and IGFBP-3 levels in the lower normal range. The type of OI does not significantly influence these growth factors.<\/jats:p>","DOI":"10.1515\/jpem-2015-0385","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T17:22:17Z","timestamp":1461000137000},"source":"Crossref","is-referenced-by-count":8,"title":["Children with severe Osteogenesis imperfecta and short stature present on average with normal IGF-I and IGFBP-3 levels"],"prefix":"10.1515","volume":"29","author":[{"given":"Heike","family":"Hoyer-Kuhn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"H\u00f6bing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Cassens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eckhard","family":"Schoenau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Semler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref301","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000197874","article-title":"Height gains in response to growth hormone treatment to final height are similar in patients with SHOX deficiency and Turner syndrome","volume":"71","year":"2009","journal-title":"Horm Res"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/ncpendmet0169","article-title":"Use of growth hormone in children","volume":"2","year":"2006","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1212\/WNL.0000000000000737","article-title":"Growth hormone treatment for childhood short stature and risk of stroke in early adulthood","volume":"83","year":"2014","journal-title":"Neurology"},{"key":"ref351","first-page":"80","article-title":"Nutritional regulation of the insulin-like growth factors","volume":"15","year":"1994","journal-title":"Endocr Rev"},{"key":"ref81","first-page":"251","article-title":"The growth hormone and somatomedin axis in short children with osteogenesis imperfecta","volume":"76","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"ref281","first-page":"251","article-title":"The growth hormone and somatomedin axis in short children with osteogenesis imperfecta","volume":"76","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"ref151","first-page":"80","article-title":"Nutritional regulation of the insulin-like growth factors","volume":"15","year":"1994","journal-title":"Endocr Rev"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0140-6736(04)16051-0","article-title":"Osteogenesis imperfecta","volume":"363","year":"2004","journal-title":"Lancet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1988.tb55311.x","article-title":"Osteogenesis imperfecta nosology and genetics","volume":"543","year":"1988","journal-title":"Ann N Y Acad Sci"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0140-6736(04)16051-0","article-title":"Osteogenesis imperfecta","volume":"363","year":"2004","journal-title":"Lancet"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000197874","article-title":"Height gains in response to growth hormone treatment to final height are similar in patients with SHOX deficiency and Turner syndrome","volume":"71","year":"2009","journal-title":"Horm Res"},{"key":"ref161","first-page":"E356","article-title":"Muscle anatomy and dynamic muscle function in osteogenesis imperfecta type I","volume":"99","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref181","first-page":"571","article-title":"The \u201cmuscle-bone unit\u201d in children and adolescents: a 2000 overview","volume":"13","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/ajmg.1320450223","article-title":"Evaluation of growth hormone axis and responsiveness to growth stimulation of short children with osteogenesis imperfecta","volume":"45","year":"1993","journal-title":"Am J Med Genet"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0022-3476(96)70077-X","article-title":"Growth hormone treatment in osteogenesis imperfecta with quantitative defect of type I collagen synthesis","volume":"129","year":"1996","journal-title":"J Pediatr"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1055\/s-0028-1093710","article-title":"On an attempt to treat primary and secondary osteoporosis with human growth hormone","volume":"7","year":"1975","journal-title":"Horm Metab Res"},{"key":"ref91","first-page":"999","article-title":"Just taller or more bone? 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