{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:39:08Z","timestamp":1772771948485,"version":"3.50.1"},"reference-count":64,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vaspin (VASP) is a protein detected in pre- and mature adipocytes, the production and secretion of which may be conditioned by nutrition status. VASP may also play a role in the regulation of food intake. Since to date, there are no available studies on serum vaspin concentrations in patients with anorexia nervosa (AN), the aim of our study is to assess serum vaspin concentrations in girls with AN in comparison to healthy subjects and determine its relationship with body weight, body masss index (BMI) and insulin.<\/jats:p><jats:p>In this cross-sectional study vaspin serum concentrations were evaluated using a commercially available ELISA kit in 47 Polish girls hospitalized due to restrictive AN and 39 healthy controls (H).<\/jats:p><jats:p>The mean serum concentration of VASP in girls with AN was significantly higher than in the H group. These differences were also noted after adjustment for body masss index-standard deviation score (BMI-SDS), the homeostatic model assessment-insulin resistance (HOMA-IR) index and insulin levels. There were no statistically significant correlations between the serum concentrations of VASP and body mass, BMI, BMI-SDS, insulin and HOMA-IR in the AN or healthy group.<\/jats:p><jats:p>Serum vaspin levels in lean subjects are regulated in different mechanisms than previously reported in obesity. It should be established if elevated serum vaspin levels in girls with AN may contribute to low food intake in these patients.<\/jats:p>","DOI":"10.1515\/jpem-2015-0390","type":"journal-article","created":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T18:39:40Z","timestamp":1460054380000},"source":"Crossref","is-referenced-by-count":6,"title":["Serum vaspin concentrations in girls with anorexia nervosa"],"prefix":"10.1515","volume":"29","author":[{"given":"Joanna","family":"O\u015bwi\u0119cimska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Suwa\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"\u015awi\u0119tochowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zofia","family":"Ostrowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Gorczyca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Ziora-Jakutowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edyta","family":"Machura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Szczepa\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Hyla-Klekot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Kukla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariusz","family":"Ziora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Ziora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref401","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2337\/db07-1045","article-title":"Serum vaspin concentrations in human obesity and type 2 diabetes","volume":"57","year":"2008","journal-title":"Diabetes"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"e54140","DOI":"10.1371\/journal.pone.0054140","article-title":"Role of vaspin in human eating behaviour","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.2337\/db08-0127","article-title":"Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance","volume":"57","year":"2008","journal-title":"Diabetes"},{"key":"ref621","first-page":"1065","article-title":"Role of circulating adipocytokines vaspin, apelin, and visfatin in the loss of appetite in underweight children: a pilot trial","volume":"28","year":"2015","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref121","first-page":"230","article-title":"Adipokines \u2013 removing road blocks to obesity and diabetes therapy","volume":"21","year":"2014","journal-title":"Mol Metab"},{"key":"ref601","doi-asserted-by":"crossref","first-page":"342","DOI":"10.2337\/dc11-1267","article-title":"Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention","volume":"35","year":"2012","journal-title":"Diabetes Care"},{"key":"ref491","first-page":"148","article-title":"Jad\u0142owstr\u0119t psychiczny","volume":"59","year":"2008","journal-title":"Endokrynol Pol"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1007\/s00125-011-2137-1","article-title":"Central vaspin administration acutely reduces food intake and has sustained blood glucose-lowering effects","volume":"54","year":"2011","journal-title":"Diabetologia"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"10610","DOI":"10.1073\/pnas.0504703102","article-title":"Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1684\/ecn.2011.0295","article-title":"Short-term effect of weight loss through restrictive bariatric surgery on serum levels of vaspin in morbidly obese subjects","volume":"22","year":"2011","journal-title":"Eur Cytokine Netw"},{"key":"ref361","first-page":"236","article-title":"Nowe adipokiny \u2013 korzystne czy niekorzystne w aspekcie patogenezy insulinooporno\u015bci?","volume":"5","year":"2009","journal-title":"Endokrynologia, Oty\u0142o\u015b\u0107 i Zaburzenia Przemiany Materii"},{"key":"ref101","first-page":"265","article-title":"Relationship of plasma level of chemerin and vaspin to early atherosclerotic changes and cardiac autonomic neuropathy in adolescent type 1 diabetic patients","volume":"28","year":"2015","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1210\/jc.2009-1088","article-title":"Circadian rhythm of serum vaspin in healthy male volunteers: relation to meals","volume":"95","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"342","DOI":"10.2337\/dc11-1267","article-title":"Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention","volume":"35","year":"2012","journal-title":"Diabetes Care"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.metabol.2009.11.021","article-title":"Association between serum vaspin concentrations and visceral adipose tissue in Korean subjects","volume":"59","year":"2010","journal-title":"Metabolism"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.peptides.2011.08.003","article-title":"Effects of vaspin, chemerin and omentin-1 on feeding behavior and hypothalamic peptide gene expression in the rat","volume":"32","year":"2011","journal-title":"Peptides"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s12020-011-9572-0","article-title":"Vaspin in obesity and diabetes: pathophysiological and clinical significance","volume":"41","year":"2012","journal-title":"Endocrine"},{"key":"ref201","first-page":"903","article-title":"Serum visfatin levels in patients with anorexia nervosa and bulimia nervosa","volume":"58","year":"2009","journal-title":"Physiol Res"},{"key":"ref431","first-page":"265","article-title":"Relationship of plasma level of chemerin and vaspin to early atherosclerotic changes and cardiac autonomic neuropathy in adolescent type 1 diabetic patients","volume":"28","year":"2015","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s12020-011-9572-0","article-title":"Vaspin in obesity and diabetes: pathophysiological and clinical significance","volume":"41","year":"2012","journal-title":"Endocrine"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1007\/s10753-013-9620-4","article-title":"Adipocytokine levels in obese and non-obese subjects: an observational study","volume":"36","year":"2013","journal-title":"Inflammation"},{"key":"ref631","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.2337\/db08-0127","article-title":"Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance","volume":"57","year":"2008","journal-title":"Diabetes"},{"key":"ref191","first-page":"1","article-title":"The Eating Disorder Examination: a semi-structured interview for the assessment of the specific psychopathology of eating disorders","volume":"1","year":"1987","journal-title":"Int J Eat Dis"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ijo.2010.196","article-title":"Vaspin is related to gender, puberty and deteriorating insulin sensitivity in children","volume":"35","year":"2011","journal-title":"Int J Obes (Lond)"},{"key":"ref501","first-page":"108","article-title":"Somatic development indices in children and youth of Warsaw","volume":"2","year":"2001","journal-title":"Med Wieku Rozwoj"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1177\/147323000803600402","article-title":"A novel adipocytokine, visceral adipose tissue-derived serine protease inhibitor (vaspin), and obesity","volume":"36","year":"2008","journal-title":"J Int Med Res"},{"key":"ref31","first-page":"236","article-title":"Nowe adipokiny \u2013 korzystne czy niekorzystne w aspekcie patogenezy insulinooporno\u015bci?","volume":"5","year":"2009","journal-title":"Endokrynologia, Oty\u0142o\u015b\u0107 i Zaburzenia Przemiany Materii"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1684\/ecn.2011.0295","article-title":"Short-term effect of weight loss through restrictive bariatric surgery on serum levels of vaspin in morbidly obese subjects","volume":"22","year":"2011","journal-title":"Eur Cytokine Netw"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.peptides.2011.08.003","article-title":"Effects of vaspin, chemerin and omentin-1 on feeding behavior and hypothalamic peptide gene expression in the rat","volume":"32","year":"2011","journal-title":"Peptides"},{"key":"ref551","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1177\/147323000803600402","article-title":"A novel adipocytokine, visceral adipose tissue-derived serine protease inhibitor (vaspin), and obesity","volume":"36","year":"2008","journal-title":"J Int Med Res"},{"key":"ref641","first-page":"635","article-title":"Umbilical cord and fifth-day serum vaspin concentrations in small-, appropriate-, and large-for-gestational age neonates","volume":"26","year":"2013","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref561","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.metabol.2009.11.021","article-title":"Association between serum vaspin concentrations and visceral adipose tissue in Korean subjects","volume":"59","year":"2010","journal-title":"Metabolism"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1007\/s10753-013-9620-4","article-title":"Adipocytokine levels in obese and non-obese subjects: an observational study","volume":"36","year":"2013","journal-title":"Inflammation"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"e54140","DOI":"10.1371\/journal.pone.0054140","article-title":"Role of vaspin in human eating behaviour","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1471-2350-12-60","article-title":"New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women","volume":"12","year":"2011","journal-title":"BMC Med Genet"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.metabol.2011.01.013","article-title":"Lifestyle modification increases circulating adiponectin concentrations but does not change vaspin concentrations","volume":"60","year":"2011","journal-title":"Metabolism"},{"key":"ref451","first-page":"230","article-title":"Adipokines \u2013 removing road blocks to obesity and diabetes therapy","volume":"21","year":"2014","journal-title":"Mol Metab"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s00018-013-1258-8","article-title":"Vaspin inhibits kallikrein 7 by serpin mechanism","volume":"70","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s00018-013-1258-8","article-title":"Vaspin inhibits kallikrein 7 by serpin mechanism","volume":"70","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1159\/000321637","article-title":"Serum vaspin concentrations are decreased after exercise-induced oxidative stress","volume":"3","year":"2010","journal-title":"Obes Facts"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1210\/jc.2009-1088","article-title":"Circadian rhythm of serum vaspin in healthy male volunteers: relation to meals","volume":"95","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.diabres.2009.03.008","article-title":"Vaspin and its correlation with insulin sensitivity indices in obese children","volume":"84","year":"2009","journal-title":"Diabetes Res Clin Pract"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ijo.2010.196","article-title":"Vaspin is related to gender, puberty and deteriorating insulin sensitivity in children","volume":"35","year":"2011","journal-title":"Int J Obes (Lond)"},{"key":"ref171","first-page":"108","article-title":"Somatic development indices in children and youth of Warsaw","volume":"2","year":"2001","journal-title":"Med Wieku Rozwoj"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1007\/s00125-011-2137-1","article-title":"Central vaspin administration acutely reduces food intake and has sustained blood glucose-lowering effects","volume":"54","year":"2011","journal-title":"Diabetologia"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1471-2350-12-60","article-title":"New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women","volume":"12","year":"2011","journal-title":"BMC Med Genet"},{"key":"ref611","first-page":"e111002","article-title":"Increased vaspin levels are associated with beneficial metabolic outcome pre- and post-bariatric surgery","volume":"23","year":"2014","journal-title":"PLoS One"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2337\/db07-1045","article-title":"Serum vaspin concentrations in human obesity and type 2 diabetes","volume":"57","year":"2008","journal-title":"Diabetes"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"10610","DOI":"10.1073\/pnas.0504703102","article-title":"Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref531","first-page":"903","article-title":"Serum visfatin levels in patients with anorexia nervosa and bulimia nervosa","volume":"58","year":"2009","journal-title":"Physiol Res"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1159\/000321637","article-title":"Serum vaspin concentrations are decreased after exercise-induced oxidative stress","volume":"3","year":"2010","journal-title":"Obes Facts"},{"key":"ref311","first-page":"635","article-title":"Umbilical cord and fifth-day serum vaspin concentrations in small-, appropriate-, and large-for-gestational age neonates","volume":"26","year":"2013","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/psc.2621","article-title":"Vaspin (serpin A12) in obesity, insulin resistance, and inflammation","volume":"20","year":"2014","journal-title":"J Pept Sci"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1210\/jc.2013-1694","article-title":"Chronic starvation secondary to anorexia nervosa is associated with an adaptive suppression of resting energy expenditure","volume":"99","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref521","first-page":"1","article-title":"The Eating Disorder Examination: a semi-structured interview for the assessment of the specific psychopathology of eating disorders","volume":"1","year":"1987","journal-title":"Int J Eat Dis"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.diabres.2009.03.008","article-title":"Vaspin and its correlation with insulin sensitivity indices in obese children","volume":"84","year":"2009","journal-title":"Diabetes Res Clin Pract"},{"key":"ref291","first-page":"1065","article-title":"Role of circulating adipocytokines vaspin, apelin, and visfatin in the loss of appetite in underweight children: a pilot trial","volume":"28","year":"2015","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1210\/jc.2013-1694","article-title":"Chronic starvation secondary to anorexia nervosa is associated with an adaptive suppression of resting energy expenditure","volume":"99","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/0148607105029003148","article-title":"Body mass index and agreement between bioimpedance and anthropometry estimates of body compartments in anorexia nervosa","volume":"29","year":"2005","journal-title":"J Parenter Enteral Nutr"},{"key":"ref591","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.metabol.2011.01.013","article-title":"Lifestyle modification increases circulating adiponectin concentrations but does not change vaspin concentrations","volume":"60","year":"2011","journal-title":"Metabolism"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/psc.2621","article-title":"Vaspin (serpin A12) in obesity, insulin resistance, and inflammation","volume":"20","year":"2014","journal-title":"J Pept Sci"},{"key":"ref651","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/0148607105029003148","article-title":"Body mass index and agreement between bioimpedance and anthropometry estimates of body compartments in anorexia nervosa","volume":"29","year":"2005","journal-title":"J Parenter Enteral Nutr"},{"key":"ref161","first-page":"148","article-title":"Jad\u0142owstr\u0119t psychiczny","volume":"59","year":"2008","journal-title":"Endokrynol Pol"},{"key":"ref281","first-page":"e111002","article-title":"Increased vaspin levels are associated with beneficial metabolic outcome pre- and post-bariatric surgery","volume":"23","year":"2014","journal-title":"PLoS One"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2015-0390\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T01:40:07Z","timestamp":1619055607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2015-0390\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":64,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1515\/jpem-2015-0390","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1,1]]}}}