{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T18:03:47Z","timestamp":1648836227369},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Central diabetes insipidus (CDI) and relapse are frequently seen in multifocal Langerhans cell histiocytosis (LCH). We present two females with multifocal LCH who developed CDI 9 and 5 years after the initial diagnosis, respectively, as a relapse limited to the pituitary stalk. Combination chemotherapy with cytarabine reduced the mass in the pituitary stalk. Although CDI did not improve, there has been no anterior pituitary hormone deficiency (APHD), neurodegenerative disease in the central nervous system (ND-CNS) or additional relapse for 2 years after therapy. It was difficult to predict the development of CDI in these cases. CDI might develop very late in patients with multifocal LCH, and therefore strict follow-up is necessary, especially with regard to symptoms of CDI such as polydipsia and polyuria. For new-onset CDI with LCH, chemotherapy with cytarabine might be useful for preventing APHD and ND-CNS.<\/jats:p>","DOI":"10.1515\/jpem-2015-0391","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T17:22:17Z","timestamp":1461000137000},"source":"Crossref","is-referenced-by-count":2,"title":["Central diabetes insipidus as a very late relapse limited to the pituitary stalk in Langerhans cell histiocytosis"],"prefix":"10.1515","volume":"29","author":[{"given":"Shunsuke","family":"Nakagawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Shinkoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Hazeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref231","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s12185-011-0965-x","article-title":"Analysis of 43 cases of Langerhans cell histiocytosis (LCH)-induced central diabetes insipidus registered in the JLSG-96 and JLSG-02 studies in Japan","volume":"94","year":"2011","journal-title":"Int J Hematol"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/pbc.20425","article-title":"Risk factors for diabetes insipidus in Langerhans cell histiocytosis","volume":"46","year":"2006","journal-title":"Pediatr Blood Cancer"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/B978-0-12-375154-6.00018-5","volume-title":"Manual of pediatric hematology and oncology","year":"2011"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jpeds.2008.05.002","article-title":"Reactivations in multisystem Langerhans cell histiocytosis: Data of the International LCH Registry","volume":"153","year":"2008","journal-title":"J Pediatr"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/pbc.21225","article-title":"Analysis of outcome for patients with mass lesions of the central nervous system due to Langerhans cell histiocytosis treated with 2-chlorodeoxyadenosine","volume":"50","year":"2008","journal-title":"Pediatr Blood Cancer"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/pbc.22478","article-title":"VCR\/AraC chemotherapy and ND-CNS-LCH","volume":"55","year":"2010","journal-title":"Pediatr Blood Cancer"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jpeds.2008.05.002","article-title":"Reactivations in multisystem Langerhans cell histiocytosis: Data of the International LCH Registry","volume":"153","year":"2008","journal-title":"J Pediatr"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s12185-009-0420-4","article-title":"Langerhans cell histiocytosis with multifocal bone lesions: comparative clinical features between single and multi-systems","volume":"90","year":"2009","journal-title":"Int J Haematol"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1056\/NEJM198910263211704","article-title":"The frequency and natural history of diabetes insipidus in children with Langerhans-cell histiocytosis","volume":"321","year":"1989","journal-title":"N Engl J Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/(SICI)1096-911X(199704)28:4<289::AID-MPO8>3.0.CO;2-E","article-title":"Diabetes insipidus associated with Langerhans cell histiocytosis: is it reversible?","volume":"28","year":"1997","journal-title":"Med Pediatr Oncol"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s12185-009-0420-4","article-title":"Langerhans cell histiocytosis with multifocal bone lesions: comparative clinical features between single and multi-systems","volume":"90","year":"2009","journal-title":"Int J Haematol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/cncr.21985","article-title":"Improved outcome in the treatment of pediatric multifocal langerhans cell histiocytosis. 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