{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:27:26Z","timestamp":1778642846783,"version":"3.51.4"},"reference-count":62,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to identify variables that might interfere with reaching the near final height (NFH) in Congenital adrenal hyperplasia (CAH) due to classic 21-hydroxylase deficiency (21-OHD).<\/jats:p><jats:p>A cross-sectional study of 82 (24 males and 58 females) classic (23 salt-wasting form [SW] and 59 simple-virilizing form [SV]) CAH 21-OHD patients seen in our institution between 1989 and 2015 with 10.6 (0.5~25.5) years of follow-up who reached their NFH was conducted. The variables related to NFH were explored.<\/jats:p><jats:p>NFH (153.35\u00b18.31) cm, (\u20131.9\u00b11.1) SD was significantly lower than the normal population (p&lt;0.001). The treated patients reached a significantly higher NFH (\u20131.7\u00b11.1) SD than those untreated (\u20132.6\u00b11.0) SD (p&lt;0.05). Both of early treatment and late treatment group were taller than untreated group (p&lt;0.001, p=0.013, respectively), and early treatment group had a taller height trend than late treatment group (p=0.089). A better height outcome was observed in patients with advantage in target height, good compliance, and low hydrocortisone dose by multivariate Cox regression analysis in 62 treatment patients. NFH and hydrocortisone dose was negatively correlated (r=\u20130.23, p=0.078) in treated group. Patients complicated by central precocious puberty (CPP) received gonadotropin-releasing hormone analogue (GnRHa) plus letrozole had increased NFH with height SD for bone age and Ht SD improved after treatment compare to no intervention group (p=0.001, p=0.035).<\/jats:p><jats:p>Patients with classic 21-OHD have blunted final height, as compared with their target height and the population norm, not-treated even worse. Careful treatment adjustments have a favorable influence on growth. Alternative treatments, such as the use of puberty inhibitors GnRHa in addition to anti-estrogen therapy letrozole can somewhat improve NFH in children with 21-OHD complicated by CPP.<\/jats:p>","DOI":"10.1515\/jpem-2015-0406","type":"journal-article","created":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T18:39:40Z","timestamp":1460054380000},"source":"Crossref","is-referenced-by-count":18,"title":["Near-final height in 82 Chinese patients with congenital adrenal hyperplasia due to classic 21-hydroxylase deficiency: a single-center study from China"],"prefix":"10.1515","volume":"29","author":[{"given":"Lin","family":"Juan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma","family":"Huamei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su","family":"Zhe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yanhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Hongshan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Qiuli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Jun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Du","family":"Minlian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref221","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1210\/jc.2006-2109","article-title":"Reduced final height outcome in congenital adrenal hyperplasia under prednisone treatment: deceleration of growth velocity during puberty","volume":"92","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref391","first-page":"487","article-title":"Height and weight standardized growth charts for Chinese children and adolescents aged 0 to 18 years","volume":"47","year":"2009","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"ref551","first-page":"180","article-title":"The calculation of target height reconsidered","volume":"59","year":"2003","journal-title":"Horm Res"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1210\/jc.2006-2109","article-title":"Reduced final height outcome in congenital adrenal hyperplasia under prednisone treatment: deceleration of growth velocity during puberty","volume":"92","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref81","first-page":"493","article-title":"Body mass index growth curves for Chinese children and adolescents aged 0 to 18 years","volume":"47","year":"2009","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"ref271","first-page":"245","article-title":"Experience with long-term glucocorticoid treatment in congenital adrenal hyperplasia: growth pattern compared with genetic height potential","volume":"19","year":"2006","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref281","first-page":"S172","article-title":"Pharmacological management of children with short stature: the role of aromatase inhibitors","volume":"83","year":"2007","journal-title":"J Pediatr (Rio J)"},{"key":"ref181","first-page":"277","article-title":"Final height in congenital adrenal hyperplasia due to 21-hydroxylase deficiency: the Italian experience","volume":"16","year":"2003","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref631","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1136\/adc.78.3.261","article-title":"Obesity in 21-hydroxylase deficient patients","volume":"78","year":"1998","journal-title":"Arch Dis Child"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1210\/jc.2008-0509","article-title":"Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the growth hormone research society, the lawson wilkins pediatric endocrine society, and the european society for paediatric endocrinology workshop","volume":"93","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"265","DOI":"10.14310\/horm.2002.1555","article-title":"Gonadotropin releasing hormone analog treatment in children with congenital adrenal hyperplasia complicated by central precocious puberty","volume":"14","year":"2015","journal-title":"Hormones (Athens)"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"e752","DOI":"10.1542\/peds.2008-1783","article-title":"Consensus statement on the use of gonadotropin-releasing hormone analogs in children","volume":"123","year":"2009","journal-title":"Pediatrics"},{"key":"ref561","first-page":"977","article-title":"Gender related differences in glucocorticoid therapy and growth outcomes among pubertal children with 21-hydroxylase deficiency congenital adrenal hyperplasia (CAH)","volume":"25","year":"2012","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref621","doi-asserted-by":"crossref","first-page":"265","DOI":"10.14310\/horm.2002.1555","article-title":"Gonadotropin releasing hormone analog treatment in children with congenital adrenal hyperplasia complicated by central precocious puberty","volume":"14","year":"2015","journal-title":"Hormones (Athens)"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0026-0495(97)90186-4","article-title":"Congenital adrenal hyperplasia complicated by central precocious puberty: linear growth during infancy and treatment with gonadotropin-releasing hormone analog","volume":"46","year":"1997","journal-title":"Metabolism"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1001\/jama.288.4.455","article-title":"Long-term persistence in use of statin therapy in elderly patients","volume":"288","year":"2002","journal-title":"J Am Med Assoc"},{"key":"ref241","first-page":"977","article-title":"Gender related differences in glucocorticoid therapy and growth outcomes among pubertal children with 21-hydroxylase deficiency congenital adrenal hyperplasia (CAH)","volume":"25","year":"2012","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1203\/00006450-199701000-00005","article-title":"Growth of patients with 21-hydroxylase deficiency: an analysis of the factors influencing adult height","volume":"41","year":"1997","journal-title":"Pediatr Res"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1524-4733.2007.00213.x","article-title":"Medication compliance and persistence: terminology and definitions","volume":"11","year":"2008","journal-title":"Value Health"},{"key":"ref531","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1067\/mpd.2001.111427","article-title":"Back to basics: early diagnosis and compliance improve final height outcome in congenital adrenal hyperplasia","volume":"138","year":"2001","journal-title":"J Pediatr"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.beem.2008.10.010","article-title":"Management of the child with congenital adrenal hyperplasia","volume":"23","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1210\/jc.2009-0942","article-title":"Hydrocortisone dosing during puberty in patients with classical congenital adrenal hyperplasia: an evidence-based recommendation","volume":"94","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref511","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1046\/j.1365-2265.2002.01645.x","article-title":"Early growth, pubertal development, body mass index and final height of patients with congenital adrenal hyperplasia: factors influencing the outcome","volume":"57","year":"2002","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref341","first-page":"91","article-title":"Growth and final height in classical and nonclassical 21-hydroxylase deficiency","volume":"12","year":"1989","journal-title":"J Endocrinol Invest"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1210\/jc.2009-0942","article-title":"Hydrocortisone dosing during puberty in patients with classical congenital adrenal hyperplasia: an evidence-based recommendation","volume":"94","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1136\/adc.78.3.261","article-title":"Obesity in 21-hydroxylase deficient patients","volume":"78","year":"1998","journal-title":"Arch Dis Child"},{"key":"ref441","first-page":"161","article-title":"Growth patterns and final height in congenital adrenal hyperplasia due to classical 21-hydroxylase deficiency. Results of a multicenter study","volume":"55","year":"2001","journal-title":"Horm Res"},{"key":"ref21","first-page":"91","article-title":"Growth and final height in classical and nonclassical 21-hydroxylase deficiency","volume":"12","year":"1989","journal-title":"J Endocrinol Invest"},{"key":"ref31","first-page":"3070","article-title":"Long term outcome in adult males with classic congenital adrenal hyperplasia","volume":"86","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1001\/jama.288.4.455","article-title":"Long-term persistence in use of statin therapy in elderly patients","volume":"288","year":"2002","journal-title":"J Am Med Assoc"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1067\/mpd.2001.111427","article-title":"Back to basics: early diagnosis and compliance improve final height outcome in congenital adrenal hyperplasia","volume":"138","year":"2001","journal-title":"J Pediatr"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1210\/jc.2009-2631","article-title":"Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an endocrine society clinical practice guideline","volume":"95","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1136\/adc.45.244.755","article-title":"Standards for children\u2019s height at ages 2\u20139 years allowing for heights of parents","volume":"45","year":"1970","journal-title":"Arch Dis Child"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1067\/mpd.2001.110527","article-title":"Height outcome in congenital adrenal hyperplasia caused by 21-hydroxylase deficiency: a meta-analysis","volume":"138","year":"2001","journal-title":"J Pediatr"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0022-3476(52)80205-7","article-title":"Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards","volume":"40","year":"1952","journal-title":"J Pediatr"},{"key":"ref51","volume-title":"Radiographic atlas of skeletal development of the hand and wrist","year":"1959"},{"key":"ref371","volume-title":"Radiographic atlas of skeletal development of the hand and wrist","year":"1959"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.jpeds.2014.01.011","article-title":"Impact of hydrocortisone on adult height in congenital adrenal hyperplasia-the Minnesota cohort","volume":"164","year":"2014","journal-title":"J Pediatr"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.jpeds.2014.01.011","article-title":"Impact of hydrocortisone on adult height in congenital adrenal hyperplasia-the Minnesota cohort","volume":"164","year":"2014","journal-title":"J Pediatr"},{"key":"ref501","first-page":"277","article-title":"Final height in congenital adrenal hyperplasia due to 21-hydroxylase deficiency: the Italian experience","volume":"16","year":"2003","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.beem.2008.10.010","article-title":"Management of the child with congenital adrenal hyperplasia","volume":"23","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1067\/mpd.2001.110527","article-title":"Height outcome in congenital adrenal hyperplasia caused by 21-hydroxylase deficiency: a meta-analysis","volume":"138","year":"2001","journal-title":"J Pediatr"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1524-4733.2007.00213.x","article-title":"Medication compliance and persistence: terminology and definitions","volume":"11","year":"2008","journal-title":"Value Health"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0022-3476(52)80205-7","article-title":"Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards","volume":"40","year":"1952","journal-title":"J Pediatr"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1210\/jc.2009-2616","article-title":"Clinical review: adult height in patients with congenital adrenal hyperplasia: a systematic review and metaanalysis","volume":"95","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1210\/jc.2008-0509","article-title":"Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the growth hormone research society, the lawson wilkins pediatric endocrine society, and the european society for paediatric endocrinology workshop","volume":"93","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref601","first-page":"S172","article-title":"Pharmacological management of children with short stature: the role of aromatase inhibitors","volume":"83","year":"2007","journal-title":"J Pediatr (Rio J)"},{"key":"ref11","first-page":"403","article-title":"Beneficial effects of one-year growth hormone administration to children with juvenile chronic arthritis on chronic steroid therapy. I. Effects on growth velocity and body composition","volume":"83","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref611","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0026-0495(97)90186-4","article-title":"Congenital adrenal hyperplasia complicated by central precocious puberty: linear growth during infancy and treatment with gonadotropin-releasing hormone analog","volume":"46","year":"1997","journal-title":"Metabolism"},{"key":"ref231","first-page":"180","article-title":"The calculation of target height reconsidered","volume":"59","year":"2003","journal-title":"Horm Res"},{"key":"ref71","first-page":"487","article-title":"Height and weight standardized growth charts for Chinese children and adolescents aged 0 to 18 years","volume":"47","year":"2009","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"ref121","first-page":"161","article-title":"Growth patterns and final height in congenital adrenal hyperplasia due to classical 21-hydroxylase deficiency. Results of a multicenter study","volume":"55","year":"2001","journal-title":"Horm Res"},{"key":"ref591","first-page":"245","article-title":"Experience with long-term glucocorticoid treatment in congenital adrenal hyperplasia: growth pattern compared with genetic height potential","volume":"19","year":"2006","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref401","first-page":"493","article-title":"Body mass index growth curves for Chinese children and adolescents aged 0 to 18 years","volume":"47","year":"2009","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"ref351","first-page":"3070","article-title":"Long term outcome in adult males with classic congenital adrenal hyperplasia","volume":"86","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"e752","DOI":"10.1542\/peds.2008-1783","article-title":"Consensus statement on the use of gonadotropin-releasing hormone analogs in children","volume":"123","year":"2009","journal-title":"Pediatrics"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1203\/00006450-199701000-00005","article-title":"Growth of patients with 21-hydroxylase deficiency: an analysis of the factors influencing adult height","volume":"41","year":"1997","journal-title":"Pediatr Res"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1136\/adc.45.244.755","article-title":"Standards for children\u2019s height at ages 2\u20139 years allowing for heights of parents","volume":"45","year":"1970","journal-title":"Arch Dis Child"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1210\/jc.2009-2631","article-title":"Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an endocrine society clinical practice guideline","volume":"95","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1046\/j.1365-2265.2002.01645.x","article-title":"Early growth, pubertal development, body mass index and final height of patients with congenital adrenal hyperplasia: factors influencing the outcome","volume":"57","year":"2002","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref331","first-page":"403","article-title":"Beneficial effects of one-year growth hormone administration to children with juvenile chronic arthritis on chronic steroid therapy. I. Effects on growth velocity and body composition","volume":"83","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref491","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1210\/jc.2009-2616","article-title":"Clinical review: adult height in patients with congenital adrenal hyperplasia: a systematic review and metaanalysis","volume":"95","year":"2010","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2015-0406\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T07:40:59Z","timestamp":1748850059000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2015-0406\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":62,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.1515\/jpem-2015-0406","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1,1]]}}}