{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:30:09Z","timestamp":1792186209413,"version":"4.4.0"},"reference-count":54,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Central precocious puberty (CPP), predominant in girls, is defined by early development of secondary sexual characteristics driven by the early secretion of hypothalamic gonadotropin releasing hormone (GnRH) and subsequent gonadotropin. Recent studies have shown variation in the<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>This study attempted to investigate the relation between single-nucleotide polymorphisms (SNPs) in<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>We found genotype frequencies in rs314276 and rs221634 were significantly correlated with girls with CPP; while the C allele frequency in rs314276 showed the dominant trait. Standard deviation score (SDS) of weight and body mass index (BMI) were higher in CC homozygotes of rs314276 in girls with CPP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Our results demonstrate that the genotype of rs314276 in<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2016-0101","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T10:03:25Z","timestamp":1495188205000},"source":"Crossref","is-referenced-by-count":11,"title":["Association study of LIN28B in girls with precocious puberty"],"prefix":"10.1515","volume":"30","author":[{"given":"Yen-Chun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Hsun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai-Hsiun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Chyn","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Pin","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref491","first-page":"4","article-title":"Lin28 and let-7 in cell metabolism and cancer","volume":"4","year":"2015","journal-title":"Transl Pediatr"},{"key":"ref421","first-page":"103","article-title":"Association study in Taiwanese girls with precocious puberty","volume":"24","year":"2011","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0092-8674(00)81906-6","article-title":"he cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA","volume":"88","year":"1997","journal-title":"Cell"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"E125","DOI":"10.1210\/jc.2010-0941","article-title":"Associations between the pubertal timing-related variant in LIN28B and BMI vary across the life course","volume":"96","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.stem.2013.03.005","article-title":"Lin28: primal regulator of growth and metabolism in stem cells","volume":"12","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ng.386","article-title":"Meta-analysis of genome-wide association data identifies two loci influencing age at menarche","volume":"41","year":"2009","journal-title":"Nat Genet"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jadohealth.2012.10.273","article-title":"LIN28B polymorphism could modulate the relationship between childhood obesity and age at menarche","volume":"52","year":"2013","journal-title":"J Adolesc Health"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/ng.714","article-title":"Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies","volume":"42","year":"2010","journal-title":"Nat Genet"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/ng.383","article-title":"Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche","volume":"41","year":"2009","journal-title":"Nat Genet"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jadohealth.2012.10.273","article-title":"LIN28B polymorphism could modulate the relationship between childhood obesity and age at menarche","volume":"52","year":"2013","journal-title":"J Adolesc Health"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1148\/radiology.153.1.6473771","article-title":"Pelvic organs in premenarcheal girls real-time ultrasonography","volume":"153","year":"1984","journal-title":"Radiology"},{"key":"ref221","first-page":"4","article-title":"Lin28 and let-7 in cell metabolism and cancer","volume":"4","year":"2015","journal-title":"Transl Pediatr"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3345\/kjp.2012.55.1.6","article-title":"The genes associated with gonadotropin-releasing hormone-dependent precocious puberty","volume":"55","year":"2012","journal-title":"Korean J Pediatr"},{"key":"ref501","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.canlet.2016.02.050","article-title":"RNA-binding protein Lin28 in cancer and immunity","volume":"375","year":"2016","journal-title":"Cancer Lett."},{"key":"ref331","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/ng.382","article-title":"Genetic variation in LIN28B is associated with the timing of puberty","volume":"41","year":"2009","journal-title":"Nat Genet"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ng.386","article-title":"Meta-analysis of genome-wide association data identifies two loci influencing age at menarche","volume":"41","year":"2009","journal-title":"Nat Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4274\/jcrpe.v1i4.3","article-title":"Precocious puberty and normal variant puberty: definition, etiology, diagnosis and current management","volume":"1","year":"2009","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1056\/NEJMcp0800459","article-title":"Precocious puberty","volume":"358","year":"2008","journal-title":"N Engl J Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3345\/kjp.2012.55.1.6","article-title":"The genes associated with gonadotropin-releasing hormone-dependent precocious puberty","volume":"55","year":"2012","journal-title":"Korean J Pediatr"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tem.2009.02.004","article-title":"Childhood obesity and the timing of puberty","volume":"20","year":"2009","journal-title":"Trends Endocrinol Metab"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/ng.382","article-title":"Genetic variation in LIN28B is associated with the timing of puberty","volume":"41","year":"2009","journal-title":"Nat Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/adc.70.2.116","article-title":"Sexual precocity: sex incidence and aetiology","volume":"70","year":"1994","journal-title":"Arch Dis Child"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mce.2010.01.038","article-title":"Genetic determinants of pubertal timing in the general population","volume":"324","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-3476(86)80767-3","article-title":"The NIH experience with precocious puberty: diagnostic subgroups and response to short-term luteinizing hormone releasing hormone analogue therapy","volume":"108","year":"1986","journal-title":"J Pediatr"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3345\/kjp.2012.55.10.388","article-title":"LIN28B polymorphisms are associated with central precocious puberty and early puberty in girls","volume":"55","year":"2012","journal-title":"Korean J Pediatr"},{"key":"ref191","volume-title":"Introduction to genetic analysis","year":"2007"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"E125","DOI":"10.1210\/jc.2010-0941","article-title":"Associations between the pubertal timing-related variant in LIN28B and BMI vary across the life course","volume":"96","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/pr.2016.107","article-title":"Association of genetic polymorphisms around the LIN28B gene and idiopathic central precocious puberty risks among Chinese girls","volume":"80","year":"2016","journal-title":"Pediatr Res"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/adc.70.2.116","article-title":"Sexual precocity: sex incidence and aetiology","volume":"70","year":"1994","journal-title":"Arch Dis Child"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/ng.383","article-title":"Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche","volume":"41","year":"2009","journal-title":"Nat Genet"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/pr.2016.107","article-title":"Association of genetic polymorphisms around the LIN28B gene and idiopathic central precocious puberty risks among Chinese girls","volume":"80","year":"2016","journal-title":"Pediatr Res"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1148\/radiology.153.1.6473771","article-title":"Pelvic organs in premenarcheal girls real-time ultrasonography","volume":"153","year":"1984","journal-title":"Radiology"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/ng.385","article-title":"Genome-wide association studies identify loci associated with age at menarche and age at natural menopause","volume":"41","year":"2009","journal-title":"Nat Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-3476(86)80767-3","article-title":"The NIH experience with precocious puberty: diagnostic subgroups and response to short-term luteinizing hormone releasing hormone analogue therapy","volume":"108","year":"1986","journal-title":"J Pediatr"},{"key":"ref511","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2174\/2211536611201010034","article-title":"Function and Regulation of Let-7 Family microRNAs","volume":"1","year":"2012","journal-title":"MicroRNA"},{"key":"ref151","first-page":"103","article-title":"Association study in Taiwanese girls with precocious puberty","volume":"24","year":"2011","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tem.2009.02.004","article-title":"Childhood obesity and the timing of puberty","volume":"20","year":"2009","journal-title":"Trends Endocrinol Metab"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mce.2010.01.038","article-title":"Genetic determinants of pubertal timing in the general population","volume":"324","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.1154040","article-title":"Selective blockade of microRNA processing by Lin28","volume":"320","year":"2008","journal-title":"Science"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.canlet.2016.02.050","article-title":"RNA-binding protein Lin28 in cancer and immunity","volume":"375","year":"2016","journal-title":"Cancer Lett."},{"key":"ref171","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3345\/kjp.2012.55.10.388","article-title":"LIN28B polymorphisms are associated with central precocious puberty and early puberty in girls","volume":"55","year":"2012","journal-title":"Korean J Pediatr"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.1154040","article-title":"Selective blockade of microRNA processing by Lin28","volume":"320","year":"2008","journal-title":"Science"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"e48785","DOI":"10.1371\/journal.pone.0048785","article-title":"Association of LIN28B with adult adiposity-related traits in females","volume":"7","year":"2012","journal-title":"PLoS One"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4274\/jcrpe.v1i4.3","article-title":"Precocious puberty and normal variant puberty: definition, etiology, diagnosis and current management","volume":"1","year":"2009","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.stem.2013.03.005","article-title":"Lin28: primal regulator of growth and metabolism in stem cells","volume":"12","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1210\/jc.2009-2344","article-title":"LIN28B in constitutional delay of growth and puberty","volume":"95","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0092-8674(00)81906-6","article-title":"he cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA","volume":"88","year":"1997","journal-title":"Cell"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/ng.385","article-title":"Genome-wide association studies identify loci associated with age at menarche and age at natural menopause","volume":"41","year":"2009","journal-title":"Nat Genet"},{"key":"ref531","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1210\/jc.2009-2344","article-title":"LIN28B in constitutional delay of growth and puberty","volume":"95","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref461","volume-title":"Introduction to genetic analysis","year":"2007"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/ng.714","article-title":"Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies","volume":"42","year":"2010","journal-title":"Nat Genet"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1056\/NEJMcp0800459","article-title":"Precocious puberty","volume":"358","year":"2008","journal-title":"N Engl J Med"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"e48785","DOI":"10.1371\/journal.pone.0048785","article-title":"Association of LIN28B with adult adiposity-related traits in females","volume":"7","year":"2012","journal-title":"PLoS One"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2174\/2211536611201010034","article-title":"Function and Regulation of Let-7 Family microRNAs","volume":"1","year":"2012","journal-title":"MicroRNA"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jpem.2017.30.issue-6\/jpem-2016-0101\/jpem-2016-0101.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2016-0101\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T01:40:50Z","timestamp":1619055650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2016-0101\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":54,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1515\/jpem-2016-0101","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,1]]}}}