{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T02:22:37Z","timestamp":1776306157739,"version":"3.50.1"},"reference-count":58,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Central diabetes insipidus (CDI) is a heterogeneous disease caused by arginine vasopressin deficiency; its management implies a profound understanding of the pathophysiology and the clinical spectrum. The aim of the study was to describe the clinical characteristics that indicate organicity in children and adolescents with central diabetes insipidus treated at the Department of Endocrinology from The Child Health\u2019s Institute during 2001 to 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Cross-sectional, retrospective study. 79 cases of patients diagnosed with CDI (51 males and 28 females) from 1 month to 16 years of age were reviewed. For the descriptive analysis, measures of central tendency and dispersion were used; groups of organic and idiopathic CDI were compared using \u03c7<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The average age of patients was 8.1\u00b14.2 years. Organic causes were intracranial tumors, 44 (55.7%), Langerhans cell histiocytosis (LCH), 11 (13.9%) and cerebral malformations in 7 (8.9%) patients, while the idiopathic group was 14 (17.7%) patients. Regarding clinical characteristics suggestive of organicity, headache (p=0.02) and visual disturbances (p=0.01) were found statistically significant. The anterior pituitary hormonal abnormalities were documented in 34 (52.3%) organic CDI patients. Furthermore, we did not find a significant difference in the average daily dose of desmopressin between patients with permanent vs. transitory CDI (0.81\u00b10.65 vs. 0.59\u00b10.62; p=0.363).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The main clinical features suggestive of organicity in pediatric patients with central diabetes insipidus were headache and visual disturbances; furthermore, anterior pituitary hormonal abnormalities suggest an underlying organic etiology.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2016-0140","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T10:01:10Z","timestamp":1479204070000},"source":"Crossref","is-referenced-by-count":2,"title":["Central diabetes insipidus: clinical profile that suggests organicity in Peruvian children: Lima \u2013 Peru 2001\u20132013"],"prefix":"10.1515","volume":"29","author":[{"given":"Miguel Angel","family":"De los Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Manuel Del","family":"\u00c1guila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Isabel","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Manuel","family":"Falen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oswaldo","family":"Nu\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana Manuela","family":"Ch\u00e1vez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar Antonio","family":"Espinoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola Marianella","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha Rosario","family":"Calagua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref551","first-page":"293","volume-title":"William\u00b4s textbook of endocrinology","year":"2011"},{"key":"ref371","first-page":"1","article-title":"Central diabetes insipidus as the inaugural manifestation of Langerhans cell histiocytosis: natural history and medical evaluation of 26 children and adolescents","volume":"96","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1136\/adc.79.1.84","article-title":"Diabetes insipidus","volume":"79","year":"1998","journal-title":"Arch Dis Child"},{"key":"ref501","first-page":"336","volume-title":"Tratado de Endocrinolog\u00eda 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