{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:59:09Z","timestamp":1789945149258,"version":"4.0.1"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Anti-M\u00fcllerian hormone (AMH) is produced by granulosa cells surrounding follicles that have undergone recruitment from the primordial follicle pool but have not been selected for dominance (preantral and early antral follicles). In healthy girls, serum levels of AMH vary considerably between individuals. We aimed to evaluate the AMH level in girls with premature thelarche (PT) and central precocious puberty (CPP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Girls with CPP (n=21), PT (n=24) and a control prepubertal group (n=22) were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>AMH levels were significantly higher in the PT group than the prepubertal control group and similar to the CPP group. AMH levels in the CPP group were similar to the prepubertal control group. AMH levels showed a significant negative correlation with luteinizing hormone (LH), free testosterone and dehydroepiandrosterone sulphate (DHEAS) levels in the PT group. AMH levels were negatively correlated with height standard deviation score (HSDS), body mass index (BMI) SDS values and positively correlated with sex hormone binding globulin (SHBG) levels in the CPP group. These levels were positively correlated with SHBG levels in the control prepubertal group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Serum AMH levels in girls with PT was found to be higher than in prepubertal girls. AMH levels in the CPP group were not different compared with the PT and control groups.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2016-0217","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T10:04:45Z","timestamp":1488276285000},"source":"Crossref","is-referenced-by-count":14,"title":["AMH levels in girls with various pubertal problems"],"prefix":"10.1515","volume":"30","author":[{"given":"Senay","family":"Savas-Erdeve","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Sagsak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meliksah","family":"Keskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semra","family":"Cetinkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Aycan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref121","first-page":"3836","article-title":"Expression of anti-M\u00fcllerian hormone during and normal pathological gonadal development: association with differentiation of Sertoli and granulose cells","volume":"84","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/humrep\/der435","article-title":"Individual serum levels of anti-M\u00fcllerian hormone in healthy girls persist through childhood and adolescence: a longitudinal cohort study","volume":"27","year":"2012","journal-title":"Hum Reprod"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/humrep\/der435","article-title":"Individual serum levels of anti-M\u00fcllerian hormone in healthy girls persist through childhood and adolescence: a longitudinal cohort study","volume":"27","year":"2012","journal-title":"Hum Reprod"},{"key":"ref31","first-page":"1351","article-title":"AMH levels at central precocious puberty and premature thelarche: is it a parameter?","volume":"28","year":"2015","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1210\/jc.2010-0930","article-title":"Serum levels of 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(Oxf)"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.contraception.2009.10.004","article-title":"Anti-m\u00fcllerian hormone and obesity: insights in oral contraceptive users","volume":"81","year":"2010","journal-title":"Contraception"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.contraception.2009.10.004","article-title":"Anti-m\u00fcllerian hormone and obesity: insights in oral contraceptive users","volume":"81","year":"2010","journal-title":"Contraception"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.fertnstert.2006.05.074","article-title":"Association of anti-m\u00fcllerian hormone levels with obesity in late reproductive-age women","volume":"87","year":"2007","journal-title":"Fertil Steril"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-2265.2010.03887.x","article-title":"Elevated anti-M\u00fcllerian hormone (AMH) and inhibin B 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