{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T23:53:29Z","timestamp":1726444409777},"reference-count":52,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Animal models have shown that the skeletal hormone osteocalcin stimulates testicular testosterone synthesis. To assess whether osteocalcin might be a useful marker to detect pubertal development disorders, we examined osteocalcin plasma concentrations in children and adolescents with and without disorders of pubertal development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Osteocalcin concentrations were investigated in a total of 244 patients with endocrine disorders (122 males, mean age: 11.87+3.77 years), including patients with precocious puberty and constitutional delay of puberty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Osteocalcin concentrations were highest among adolescents with precocious puberty and advanced pubertal development (120.60\u00b145.22 ng\/mL), while the concentrations were lowest among patients with constitutional delay of puberty (102.20\u00b137.13 ng\/mL). Overall, osteocalcin concentrations were strongly correlated with markers of bone metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Although plasma osteocalcin concentrations are associated with pubertal development in boys, it does not appear to be a useful diagnostic marker for altered pubertal development.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2016-0243","type":"journal-article","created":{"date-parts":[[2016,12,18]],"date-time":"2016-12-18T05:02:20Z","timestamp":1482037340000},"source":"Crossref","is-referenced-by-count":4,"title":["Plasma concentrations of osteocalcin are associated with the timing of pubertal progress in boys"],"prefix":"10.1515","volume":"30","author":[{"given":"Michael M.","family":"Sch\u00fcndeln","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"B\u00e4der","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cordula","family":"Kiewert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"F\u00fchrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthold P.","family":"Hauffa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinna","family":"Grasemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref01","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s001980070116","article-title":"Biochemical measurements of bone turnover in children and adolescents","volume":"11","year":"2000","journal-title":"Osteoporos Int"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.cell.2011.02.004","article-title":"Endocrine regulation of male fertility by the skeleton","volume":"144","year":"2011","journal-title":"Cell"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00198-013-2485-4","article-title":"Reference values of osteocalcin and procollagen type I N-propeptide plasma levels in a healthy Central European population aged 0-18 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