{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T14:58:22Z","timestamp":1777301902650,"version":"3.51.4"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2016-0301_s_999_w2aab2b8c51b1b7b1aab1c15b1Aa\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Bicuspid aortic valve (BAV) represents one of the strongest risk factors for aortic dissection in Turner syndrome (TS). An exact relation between the occurrence of BAV and a particular karyotype has not been established yet. The aim of this study was to determine the association between karyotype and prevalence of BAV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2016-0301_s_998_w2aab2b8c51b1b7b1aab1c15b2Aa\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Sixty-seven TS patients aged between 6.6 and 32.5 years underwent cardiac magnetic resonance imaging (MRI) study. They were divided into four cytogenetic subgroups\u221245,X karyotype (n=27); 45,X\/46,XX mosaicism (n=17); structural abnormalities of the X chromosome (n=10); and 45,X\/structural abnormality of the X chromosome mosaicism (n=13). Prevalence of BAV and odds ratio (OR) compared with the general population in the whole study group, and statistical comparison of prevalences of BAV among the individual subgroups were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2016-0301_s_997_w2aab2b8c51b1b7b1aab1c15b3Aa\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Prevalence of BAV in the whole study group was established as 28.4% [OR 208.3 (95% CI \u2013 103.8\u2013418.0); p-value&lt;0.0001]. Individuals with 45,X karyotype had the highest prevalence of BAV \u2013 40.7%, p-value&lt;0.0001. Presence of any 45,X cell line in karyotype significantly predisposed to BAV (p-value=0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2016-0301_s_996_w2aab2b8c51b1b7b1aab1c15b4Aa\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The 45,X karyotype is associated with the highest prevalence of BAV. Also, the presence of the 45,X cell line in any mosaic karyotype increases the probability of BAV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2016-0301","type":"journal-article","created":{"date-parts":[[2017,2,25]],"date-time":"2017-02-25T05:00:59Z","timestamp":1487998859000},"page":"319-325","source":"Crossref","is-referenced-by-count":17,"title":["Increased prevalence of bicuspid aortic valve in Turner syndrome links with karyotype: the crucial importance of detailed cardiovascular screening"],"prefix":"10.1515","volume":"30","author":[{"given":"Eva","family":"Kl\u00e1skov\u00e1","sequence":"first","affiliation":[{"name":"Department of Paediatrics, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u0159ina","family":"Zapletalov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Kapr\u00e1lov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"\u0160najderov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Lebl","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbyn\u011bk","family":"T\u00fcd\u00f6s","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Pavl\u00ed\u010dek","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Ostrava and Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"\u010cern\u00e1","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Ostrava and Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladim\u00edr","family":"Mih\u00e1l","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Star\u00e1","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Proch\u00e1zka","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,2,25]]},"reference":[{"key":"2026042714144188577_j_jpem-2016-0301_ref_001_w2aab2b8c51b1b7b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Stochholm K, Juul S, Juel K, Naeraa RW, Gravholt CH. 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