{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:44:37Z","timestamp":1790127877586,"version":"4.0.1"},"reference-count":16,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Measurement of 17-hydroxyprogesterone (17-OHP) in dried blood spots has been widely used as a newborn screening tool for congenital adrenal hyperplasia (CAH). Various maternal and neonatal factors can result in falsely high values of 17-OHP. There is a paucity of Indian studies in this regard because routine evaluation of newborn 17-OHP levels as a screening program is not widely practiced in India. Hence, this study was undertaken to evaluate the influence of various maternal and neonatal factors on newborn 17-OHP levels. The aim of the study was to determine the effect of various maternal and neonatal factors on the newborn 17-OHP values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Retrospective data related to a total of 3080 newborn 17-OHP values and clinical characteristics were collected for 3 years (2013\u20132015). The data were analyzed to determine the influence of various factors on 17-OHP values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The mean value of 17-OHP in our study was 5.486\u00b13.96 ng\/mL. Gender and mode of delivery did not significantly affect the 17-OHP levels. The levels were significantly higher in preterm and low birth weight babies as compared to term babies and babies with normal birth weight. Stress factors like pregnancy induced hypertension (PIH), early onset sepsis (EOS), neonatal seizures and birth asphyxia significantly increase the neonatal 17-OHP levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The levels of 17-OHP in newborns was measured around day 3 of life are very sensitive to the influence of gestational age, birth weight and presence of stress factors like maternal PIH, birth asphyxia, neonatal sepsis and neonatal seizures and should be interpreted cautiously.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2016-0459","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T10:01:03Z","timestamp":1494410463000},"source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of factors associated with elevated newborn 17-hydroxyprogesterone levels"],"prefix":"10.1515","volume":"30","author":[{"given":"V. Shobi","family":"Anandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhattacharyya","family":"Shaila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref11","first-page":"459","article-title":"Neonatal screening for congenital adrenal hyperplasia","volume":"58","year":"2012","journal-title":"Rev Assoc Med Bras (1992)"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12098-012-0856-z","article-title":"Serum 17 alpha hydroxyprogesterone in normal full term and preterm vs sick preterm and full term newborns in a tertiary hospital","volume":"80","year":"2013","journal-title":"Indian J Pediatr"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1203\/01.PDR.0000142733.50918.6E","article-title":"Effect of single and multiple courses of prenatal corticosteroids on 17-hydroxyprogesterone levels: implication for neonatal screening of congenital adrenal hyperplasia","volume":"56","year":"2004","journal-title":"Pediatr Res"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/BF02761890","article-title":"Effect of gender, birth weight and gestational age on serum 17-hydroxyprogesterone concentration and distribution among neonates in Saudi Arabia","volume":"62","year":"1995","journal-title":"Indian J Pediatr"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/BF02761890","article-title":"Effect of gender, birth weight and gestational age on serum 17-hydroxyprogesterone concentration and distribution among neonates in Saudi Arabia","volume":"62","year":"1995","journal-title":"Indian J Pediatr"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1203\/01.PDR.0000142733.50918.6E","article-title":"Effect of single and multiple courses of prenatal corticosteroids on 17-hydroxyprogesterone levels: implication for neonatal screening of congenital adrenal hyperplasia","volume":"56","year":"2004","journal-title":"Pediatr Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1210\/jc.2004-2136","article-title":"Cutoff levels of 17-\u03b1-hydroxyprogesterone in neonatal screening for congenital adrenal hyperplasia should be based on gestational age rather than on birth weight","volume":"90","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"ref141","first-page":"88","article-title":"Risk factors for elevated levels of 17-hydroxyprogesterone during neonatal intensive care unit admission","volume":"67","year":"2012","journal-title":"Acta Clinica Belgica"},{"key":"ref21","first-page":"706","article-title":"[Multicenter investigation on the impact of newborn infants\u2019 gestational age and birth weight on the level of 17alpha-hydroxyprogesterone]","volume":"52","year":"2014","journal-title":"Zhonghua er ke za zhi"},{"key":"ref61","first-page":"88","article-title":"Risk factors for elevated levels of 17-hydroxyprogesterone during neonatal intensive care unit admission","volume":"67","year":"2012","journal-title":"Acta Clinica Belgica"},{"key":"ref101","first-page":"706","article-title":"[Multicenter investigation on the impact of newborn infants\u2019 gestational age and birth weight on the level of 17alpha-hydroxyprogesterone]","volume":"52","year":"2014","journal-title":"Zhonghua er ke za zhi"},{"key":"ref41","first-page":"301","article-title":"Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns","volume":"25","year":"2012","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref91","first-page":"459","article-title":"Neonatal screening for congenital adrenal hyperplasia","volume":"58","year":"2012","journal-title":"Rev Assoc Med Bras (1992)"},{"key":"ref121","first-page":"301","article-title":"Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns","volume":"25","year":"2012","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1210\/jc.2004-2136","article-title":"Cutoff levels of 17-\u03b1-hydroxyprogesterone in neonatal screening for congenital adrenal hyperplasia should be based on gestational age rather than on birth weight","volume":"90","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12098-012-0856-z","article-title":"Serum 17 alpha hydroxyprogesterone in normal full term and preterm vs sick preterm and full term newborns in a tertiary hospital","volume":"80","year":"2013","journal-title":"Indian J Pediatr"}],"container-title":["Journal of Pediatric Endocrinology and 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