{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:21:10Z","timestamp":1770513670161,"version":"3.49.0"},"reference-count":38,"publisher":"Walter de Gruyter GmbH","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Neonatal central diabetes insipidus (NCDI) remains a therapeutic challenge, as extremely low doses of enteral desmopressin cannot be titrated with current preparations. The aim of this study was to describe the use of orally administered dilute desmopressin in NCDI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Nasal desmopressin (100 \u03bcg\/mL) was diluted in 0.9% saline to 10 \u03bcg\/mL. Infants were treated with 1\u20135 \u03bcg and doses were titrated to a twice-daily regimen. The feed volume was 150 mL\/kg\/day and titrated according to weight gain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Five infants aged 6\u2013105 days were included. Stabilizing treatment doses ranged from 2 to 5 \u03bcg twice daily in neonates, and 12 \u03bcg twice daily in the older infant who was diagnosed at 105 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Dilution of nasal desmopressin with saline facilitates safe administration and dose titration in NCDI. We recommend considering this therapeutic approach to NCDI, particularly in small infants or where alternative treatment regimens have been unsuccessful.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2017-0051","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T13:19:57Z","timestamp":1496409597000},"source":"Crossref","is-referenced-by-count":6,"title":["Oral administration of diluted nasal desmopressin in managing neonatal central diabetes insipidus"],"prefix":"10.1515","volume":"0","author":[{"given":"Meenal","family":"Mavinkurve","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niamh","family":"McGrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niall","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinead","family":"Moloney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuala P.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin P.","family":"Hawkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref291","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1172\/JCI104657","article-title":"The mechanism of antidiuresis associated with the administration of hydrochlorothiazide to patients with vasopressin-resistant diabetes insipidus","volume":"41","year":"1962","journal-title":"J Clin Invest"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1172\/JCI104657","article-title":"The mechanism of antidiuresis associated with the administration of hydrochlorothiazide to patients with vasopressin-resistant diabetes insipidus","volume":"41","year":"1962","journal-title":"J Clin Invest"},{"key":"ref261","first-page":"459","article-title":"The management of central diabetes insipidus in infancy: desmopressin, low renal solute load formula, thiazide diuretics","volume":"20","year":"2007","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1210\/jc.2016-1157","article-title":"Buccally administered intranasal desmopressin acetate for the treatment of neurogenic diabetes insipidus in infancy","volume":"101","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.juro.2007.03.015","article-title":"The comparative safety of oral versus intranasal desmopressin for the treatment of children with nocturnal enuresis","volume":"178","year":"2007","journal-title":"J Urol"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1687-9856-2014-11","article-title":"Efficacy of Hydrochlorothiazide and low renal solute feed in Neonatal Central Diabetes Insipidus with transition to Oral Desmopressin in early infancy","volume":"2014","year":"2014","journal-title":"Int J Pediatr Endocrinol"},{"key":"ref311","first-page":"769","article-title":"Transient diabetes insipidus in a preterm neonate and the challenge of desmopressin dosing","volume":"27","year":"2014","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref231","first-page":"1041","article-title":"Clinical characteristics and management of cranial diabetes insipidus in infants","volume":"26","year":"2013","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref321","first-page":"919","article-title":"Use of subcutaneous DDAVP in infants with central diabetes insipidus","volume":"19","year":"2006","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref41","first-page":"459","article-title":"The management of central diabetes insipidus in infancy: desmopressin, low renal solute load formula, thiazide diuretics","volume":"20","year":"2007","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.juro.2007.03.015","article-title":"The comparative safety of oral versus intranasal desmopressin for the treatment of children with nocturnal enuresis","volume":"178","year":"2007","journal-title":"J Urol"},{"key":"ref241","first-page":"128","article-title":"Dental fluorosis as a complication of hereditary diabetes insipidus: studies of six affected patients","volume":"16","year":"1994","journal-title":"Pediatr Dent"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/01.mph.0000168728.49519.4a","article-title":"DDAVP-induced hyponatremia in young children","volume":"27","year":"2005","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ajh.2830310310","article-title":"Hyponatremia and seizures in young children given DDAVP","volume":"31","year":"1989","journal-title":"Am J Hematol"},{"key":"ref431","first-page":"e16120","article-title":"Desmopressin lyophilisate for the treatment of central diabetes insipidus: first experience in very young infants","volume":"12","year":"2014","journal-title":"Int J Endocrinol Metab"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1136\/adc.62.11.1177","article-title":"Oral desmopressin in neonatal diabetes insipidus","volume":"62","year":"1987","journal-title":"Arch Dis Child"},{"key":"ref81","first-page":"923","article-title":"Management of central diabetes insipidus with oral desmopressin lyophilisate in infants","volume":"27","year":"2014","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00431-013-2108-2","article-title":"Pharmacokinetics of desmopressin administered as tablet and oral lyophilisate formulation in children with monosymptomatic nocturnal enuresis","volume":"173","year":"2014","journal-title":"Eur J Pediatr"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1210\/jc.2013-4411","article-title":"National Surveillance of Central Diabetes Insipidus (CDI) in Denmark: results from 5 years registration of 9309 prescriptions of desmopressin to 1285 CDI patients","volume":"99","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref91","first-page":"769","article-title":"Transient diabetes insipidus in a preterm neonate and the challenge of desmopressin dosing","volume":"27","year":"2014","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1159\/000187510","article-title":"Hereditary nephrogenic diabetes insipidus and bilateral nonobstructive hydronephrosis","volume":"65","year":"1993","journal-title":"Nephron"},{"key":"ref21","first-page":"128","article-title":"Dental fluorosis as a complication of hereditary diabetes insipidus: studies of six affected patients","volume":"16","year":"1994","journal-title":"Pediatr Dent"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1016\/j.juro.2011.02.039","article-title":"Oral lyophylizate formulation of desmopressin: superior pharmacodynamics compared to tablet due to low food interaction","volume":"185","year":"2011","journal-title":"J Urol"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1210\/jc.2016-1157","article-title":"Buccally administered intranasal desmopressin acetate for the treatment of neurogenic diabetes insipidus in infancy","volume":"101","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1210\/jc.2013-4411","article-title":"National Surveillance of Central Diabetes Insipidus (CDI) in Denmark: results from 5 years registration of 9309 prescriptions of desmopressin to 1285 CDI patients","volume":"99","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1016\/j.juro.2011.02.039","article-title":"Oral lyophylizate formulation of desmopressin: superior pharmacodynamics compared to tablet due to low food interaction","volume":"185","year":"2011","journal-title":"J Urol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1687-9856-2014-11","article-title":"Efficacy of Hydrochlorothiazide and low renal solute feed in Neonatal Central Diabetes Insipidus with transition to Oral Desmopressin in early infancy","volume":"2014","year":"2014","journal-title":"Int J Pediatr Endocrinol"},{"key":"ref101","first-page":"919","article-title":"Use of subcutaneous DDAVP in infants with central diabetes insipidus","volume":"19","year":"2006","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref211","first-page":"e16120","article-title":"Desmopressin lyophilisate for the treatment of central diabetes insipidus: first experience in very young infants","volume":"12","year":"2014","journal-title":"Int J Endocrinol Metab"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ajh.2830310310","article-title":"Hyponatremia and seizures in young children given DDAVP","volume":"31","year":"1989","journal-title":"Am J Hematol"},{"key":"ref281","first-page":"1","article-title":"Magnesium and potassium deficiency. Its diagnosis, occurrence and treatment in diuretic therapy and its consequences for growth, protein synthesis and growth factors","volume":"618","year":"1994","journal-title":"Acta Physiol Scand Suppl"},{"key":"ref11","first-page":"1041","article-title":"Clinical characteristics and management of cranial diabetes insipidus in infants","volume":"26","year":"2013","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1136\/adc.62.11.1177","article-title":"Oral desmopressin in neonatal diabetes insipidus","volume":"62","year":"1987","journal-title":"Arch Dis Child"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1159\/000187510","article-title":"Hereditary nephrogenic diabetes insipidus and bilateral nonobstructive hydronephrosis","volume":"65","year":"1993","journal-title":"Nephron"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/01.mph.0000168728.49519.4a","article-title":"DDAVP-induced hyponatremia in young children","volume":"27","year":"2005","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref61","first-page":"1","article-title":"Magnesium and potassium deficiency. Its diagnosis, occurrence and treatment in diuretic therapy and its consequences for growth, protein synthesis and growth factors","volume":"618","year":"1994","journal-title":"Acta Physiol Scand Suppl"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00431-013-2108-2","article-title":"Pharmacokinetics of desmopressin administered as tablet and oral lyophilisate formulation in children with monosymptomatic nocturnal enuresis","volume":"173","year":"2014","journal-title":"Eur J Pediatr"},{"key":"ref301","first-page":"923","article-title":"Management of central diabetes insipidus with oral desmopressin lyophilisate in infants","volume":"27","year":"2014","journal-title":"J Pediatr Endocrinol Metab"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jpem.ahead-of-print\/jpem-2017-0051\/jpem-2017-0051.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2017-0051\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T01:42:21Z","timestamp":1619055741000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2017-0051\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,23]]},"references-count":38,"journal-issue":{"issue":"0"},"URL":"https:\/\/doi.org\/10.1515\/jpem-2017-0051","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,23]]}}}