{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:50:04Z","timestamp":1789707004544,"version":"4.0.1"},"reference-count":46,"publisher":"Walter de Gruyter GmbH","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Growth hormone deficiency is a well-known clinical entity that is usually treated with somatotropin (growth hormone). Growth hormone has some frequent side effects such as intracranial hypertension, lymphedema and diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation:<\/jats:title><jats:p>We report the case of a 14-year-old girl with a history of wrist pain and clumsiness. Magnetic resonance imaging revealed de Quervain tenosynovitis. The patient had a history of using growth hormones for 12 months. We conservatively managed the patient with corticosteroid injections and oral nonsteroidal anti-inflammatory drugs and followed the course. However, the conservative treatment methods failed, and we recommended surgery, which was rejected. She was given nonsteroidal anti-inflammatory drugs and was followed up for 2 years, at the end of which her visual analog scale had decreased from 80 to 50.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>To the best of our knowledge this is the first case of de Quervain tenosynovitis related to somatotropin treatment. Physicians should consider the possibility of musculoskeletal side effects after somatotropin treatment.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2017-0085","type":"journal-article","created":{"date-parts":[[2017,10,8]],"date-time":"2017-10-08T10:01:15Z","timestamp":1507456875000},"source":"Crossref","is-referenced-by-count":4,"title":["Persistent de Quervain tenosynovitis induced by somatotropin treatment"],"prefix":"10.1515","volume":"30","author":[{"given":"Ozan Volkan","family":"Yurdakul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00fctfiye","family":"Ayt\u00fcre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru Yilmaz","family":"Yal\u00e7inkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref241","doi-asserted-by":"crossref","first-page":"757","DOI":"10.5435\/00124635-200712000-00009","article-title":"De quervain tenosynovitis of the wrist","volume":"15","year":"2007","journal-title":"J Am Acad Orthop Surg"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-0838.2009.00997.x","article-title":"Insulin-like growth factor-I E peptides: implications for ageing skeletal muscle","volume":"20","year":"2010","journal-title":"Scand J Med Sci Sports"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1210\/jc.2003-031283","article-title":"Acromegalic axial arthropathy: a clinical case-control study","volume":"89","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"E364","DOI":"10.1152\/ajpendo.00054.2007","article-title":"Growth hormone regulation of metabolic gene expression in muscle: a microarray study in hypopituitary men","volume":"293","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.clinimag.2014.02.014","article-title":"Musculoskeletal manifestations of endocrine disorders","volume":"38","year":"2014","journal-title":"Clin Imaging"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/BPB.0b013e32833ed967","article-title":"Orthopedic complications related to growth hormone therapy in a pediatric population","volume":"20","year":"2011","journal-title":"J Pediatr Orthop B"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3233\/BMR-160591","article-title":"Effectiveness of therapeutic ultrasound with or without thumb spica splint in the management of De Quervain\u2019s disease","volume":"30","year":"2017","journal-title":"J Back Musculoskelet Rehabil"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0363-5023(09)91110-8","article-title":"De Quervain\u2019s disease: surgical or nonsurgical treatment","volume":"15","year":"1990","journal-title":"J Hand Surg Am"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3122\/jabfm.16.2.102","article-title":"Corticosteroid injection for treatment of de Quervain\u2019s tenosynovitis: a pooled quantitative literature evaluation","volume":"16","year":"2003","journal-title":"J Am Board Fam Pract"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0363-5023(09)91110-8","article-title":"De Quervain\u2019s disease: surgical or nonsurgical treatment","volume":"15","year":"1990","journal-title":"J Hand Surg Am"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1365-2265.1988.tb03686.x","article-title":"Arthropathy in acromegalic patients before and after treatment: a long-term follow-up study","volume":"28","year":"1988","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.jhsa.2008.12.030","article-title":"Nonsurgical treatment for de quervain tenosynovitis","volume":"34","year":"2009","journal-title":"J Hand Surg Am"},{"key":"ref311","first-page":"299","article-title":"Orthopaedic concerns in children with growth hormone therapy","volume":"70","year":"2004","journal-title":"Acta Orthop Belg"},{"key":"ref161","first-page":"1038","article-title":"Upper Extremity Collaborative Group. 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