{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T23:02:04Z","timestamp":1781478124015,"version":"3.54.1"},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2017-0247_s_999_w2aab3b7c25b1b6b1aab1c16b1Aa\">\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>We aimed to evaluate the clinical follow-up data of patients with premature thelarche and determine the rate of development of precocious and early puberty in these patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2017-0247_s_998_w2aab3b7c25b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>The charts of 158 girls with premature thelarche who were followed-up in our pediatric endocrinology polyclinic were reviewed. The patients were divided into three groups according to the age at onset: group 1 (0\u20131 month) (n=12), group 2 (1\u201324 months) (n=40) and group 3 (2\u20138 years) (n=106).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2017-0247_s_997_w2aab3b7c25b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>At admission, the mean height standard deviation score (SDS), body weight (BW)-SDS, body mass index (BMI) and BMI-SDS were significantly higher in group 3 than in group 1 and group 2. At admission, 8.8% of the patients were obese and 24% of the patients were overweight. The majority of patients who were obese and overweight were in group 3. At the end of the follow-up, thelarche regressed in 24.7%, persisted in 32.9%, progressed in 25.9% and had a cyclic pattern in 16.5% of the patients. Precocious or rapidly progressive puberty developed in 47 of the 158 patients (29.7%). The mean age at progression to early or rapidly progressive puberty was 98.1\u00b117.6 months. A total of 89.3% of the patients who progressed to early or rapidly progressive puberty were in group 3.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2017-0247_s_996_w2aab3b7c25b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Precocious or rapidly progressive puberty developed in 29.7% of subjects with premature thelarche. As patients who developed rapidly progressive puberty had a higher BW-SDS and BMI-SDS than those who did not, it is suggested that the increase in weight could stimulate rapidly progressive puberty in cases with premature thelarche.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2017-0247","type":"journal-article","created":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T10:00:41Z","timestamp":1516960841000},"page":"305-312","source":"Crossref","is-referenced-by-count":12,"title":["Clinical follow-up data and the rate of development of precocious and rapidly progressive puberty in patients with premature thelarche"],"prefix":"10.1515","volume":"31","author":[{"given":"Dilek","family":"\u00c7i\u00e7ek","sequence":"first","affiliation":[{"name":"Dr. Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease Training and Research Hospital , Pediatric Endocrinology Department , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senay","family":"Savas-Erdeve","sequence":"additional","affiliation":[{"name":"Dr. Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease Training and Research Hospital , Pediatric Endocrinology Department , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semra","family":"Cetinkaya","sequence":"additional","affiliation":[{"name":"Dr. Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease Training and Research Hospital , Pediatric Endocrinology Department , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Aycan","sequence":"additional","affiliation":[{"name":"Dr. Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease Training and Research Hospital , Pediatric Endocrinology Department , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,1,26]]},"reference":[{"key":"2021021317394145145_j_jpem-2017-0247_ref_001_w2aab3b7c25b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Atay Z, Turan S, Guran T, Furman A, Bereket A. The prevalence and risk factors of premature thelarche and pubarche in 4- to 8-year-old girls. Acta P\u00e6diatrica 2012;101:71\u20135.","DOI":"10.1111\/j.1651-2227.2011.02444.x"},{"key":"2021021317394145145_j_jpem-2017-0247_ref_002_w2aab3b7c25b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Van Winter JT, Noller KL, Zimmerman D, Melton LJ. III. Natural history of premature thelarche in Olmsted County, Minnesota, 1940 to 1984. J Pediatr 1990;116:278\u201380.","DOI":"10.1016\/S0022-3476(05)82891-4"},{"key":"2021021317394145145_j_jpem-2017-0247_ref_003_w2aab3b7c25b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Pasquino AM, Pucarelli I, Passeri F, Segni M, Mancini MA, et al. Progression of premature thelarche to central precocious puberty. 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