{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:50:05Z","timestamp":1756993805737,"version":"3.40.5"},"reference-count":25,"publisher":"Walter de Gruyter GmbH","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2017-0300_s_999_w2aab3b7b5b1b6b1aab1c16b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Idiopathic central diabetes insipidus (CDI) has been associated with intracranial pathologies that do not involve the structural pituitary gland or hypothalamus. The objective was to study the association between non-structural hypothalamic\/pituitary intracranial pathologies (NSHPIP) with CDI and to review etiologies that may be contributory to the development of CDI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2017-0300_s_998_w2aab3b7b5b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective query of our intra-institutional database from 2006 to 2015. Children admitted diagnosed with diabetes insipidus (DI) (ICD-9 253.5) between the ages of 0\u20131 year were included. Patient charts were reviewed to include those who have a documented diagnosis of CDI, hypernatremia (&gt;145 mmol\/L), high serum osmolality (&gt;300 mOsm\/kg), low urine osmolality (&lt;300 mOsm\/kg), and brain imaging reports. Diagnoses of nephrogenic DI were excluded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2017-0300_s_997_w2aab3b7b5b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-three infant patients were diagnosed with CDI. Eleven subjects (48%) had NSHPIP. Of those, 18% had cerebral infarction, 27% had intracranial injury and hemorrhage due to traumatic brain injury, 18% had isolated intraventricular hemorrhage, and 27% had meningitis. Hospital prevalence for NSHPIP, age 0\u20131 year, ranged from 0.05% to 0.3%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2017-0300_s_996_w2aab3b7b5b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Rates of NSHPIP in those with CDI are higher than expected hospital rates (p&lt;0.001), suggesting a possible association between CDI and NSHPIP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2017-0300","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T22:16:35Z","timestamp":1532729795000},"page":"951-958","source":"Crossref","is-referenced-by-count":4,"title":["Intracranial pathologies associated with central diabetes insipidus in infants"],"prefix":"10.1515","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6112-1047","authenticated-orcid":false,"given":"Nader","family":"Kasim","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology , Le Bonheur Children\u2019s Hospital , 49 North Dunlap Street, Room 119 , Memphis, TN 38105 , USA"},{"name":"University of Tennessee Health Science Center , Memphis, TN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bindiya","family":"Bagga","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center , Memphis, TN , USA"},{"name":"Le Bonheur Children\u2019s Hospital , Memphis, TN , USA"},{"name":"St. Jude Children\u2019s Research Hospital , Memphis, TN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Diaz-Thomas","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center , Memphis, TN , USA"},{"name":"Le Bonheur Children\u2019s Hospital , Memphis, TN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,7,27]]},"reference":[{"key":"2021021318144038022_j_jpem-2017-0300_ref_001_w2aab3b7b5b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Traggiai C, Stanhope R. 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