{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T02:58:52Z","timestamp":1775617132735,"version":"3.50.1"},"reference-count":21,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2017-0433_s_999_w2aab3b7c18b1b6b1aab1c15b1Aa\">\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Congenital hypothyroidism (CH) is a common cause of mental retardation; it has a worldwide incidence ranging from 1:3000 to 1:4500 live births. Predictably, an increase in the reported incidence of primary CH occurs when the cut-off levels of thyroid-stimulating hormone are lowered. We aimed to evaluate the results of a congenital hypothyroidism screening program and current status in this study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2017-0433_s_998_w2aab3b7c18b1b6b1aab1c15b2Aa\">\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Analysis results of 1300 infants who were referred to the endocrinology polyclinic because of suspected CH within the scope of the Ministry of Health National Neonatal Screening Program were retrospectively evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2017-0433_s_997_w2aab3b7c18b1b6b1aab1c15b3Aa\">\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>The diagnosis of CH and initiation of treatment were both done in 223 (18.5%) and 10 (0.8%) infants as a result of the initial evaluation and follow-up, respectively. The mean capillary and venous thyroid-stimulating hormone (TSH) levels of 223 patients were 40.78 (5.5\u2013100) \u03bcIU\/mL and 67.26 (10.7\u2013100) \u03bcIU\/mL, respectively. These patients\u2019 mean heel prick time was 8.65 (0\u201330, median: 7) days. The mean age of the 223 infants whose treatment was initiated as a result of the initial evaluation was 19.87 (4\u201351, median: 20) days, and the mean age of the infants whose treatment was started at follow-up was 43.71 (29\u201365) days. The duration between heel prick time and venous TSH time was 11.10 (2\u201328, median: 11) days and was longer than planned (3\u20135 days).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2017-0433_s_996_w2aab3b7c18b1b6b1aab1c15b4Aa\">\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Although the duration for the diagnosis and initiation of CH treatment were markedly reduced with the implementation of the screening program in Turkey compared to those before the implementation of the screening program, we have not yet achieved the ideal time (\u226414 days).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2017-0433","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T22:16:22Z","timestamp":1526076982000},"page":"619-624","source":"Crossref","is-referenced-by-count":5,"title":["Current status of the congenital hypothyroidism neonatal screening program in Adana Province, Turkey"],"prefix":"10.1515","volume":"31","author":[{"given":"Y\u0131lmaz","family":"Kor","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology Division , Republic of Turkey , Ministry of Health, Adana City Hospital , Adana , Turkey , Phone: +90 3223444475"},{"name":"Department of Pediatrics, Division of Metabolism , Cukurova University Medical Faculty , Adana , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Kor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Metabolism , Cukurova University Medical Faculty , Adana , Turkey"},{"name":"Pediatric Metabolism Division , Republic of Turkey , Ministry of Health, Adana City Hospital , Adana , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,5,11]]},"reference":[{"key":"2025021114312382894_j_jpem-2017-0433_ref_001_w2aab3b7c18b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Rastogi MV, LaFranci SH. Congenital hypothyroidism. Orphanet J Rare Dis 2010;5:17.","DOI":"10.1186\/1750-1172-5-17"},{"key":"2025021114312382894_j_jpem-2017-0433_ref_002_w2aab3b7c18b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Ford G, La Franchi SH. Screening for congenital hypothyroidism: a world wide view of strategies. Best Pract Res Clin Endocrinol Metab 2013;28:175\u201387.","DOI":"10.1016\/j.beem.2013.05.008"},{"key":"2025021114312382894_j_jpem-2017-0433_ref_003_w2aab3b7c18b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Delado\u00eby J, Ruel J, Gigu\u00e8re Y, Van Vliet G. Is the incidence of congenital hypothyroidism really increasing? A 20-year retrospective population-based study in Qu\u00e9bec. J Clin Endocrinol Metab 2011;96:2422\u20139.","DOI":"10.1210\/jc.2011-1073"},{"key":"2025021114312382894_j_jpem-2017-0433_ref_004_w2aab3b7c18b1b6b1ab2b1b4Aa","doi-asserted-by":"crossref","unstructured":"La Franchi SH. 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