{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:38:32Z","timestamp":1764603512514,"version":"3.40.5"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2017-0451_s_999_w2aab3b7c14b1b6b1aab1c16b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hypophosphatemic rickets, including familial hypophosphatemic vitamin D-resistant rickets, which commonly manifests in childhood, is generally hereditary. X-linked dominant hypophosphatemic rickets (XLH, MIM307800), caused by inactivating mutations in the <jats:italic>PHEX<\/jats:italic> gene, is the most common form. This study aimed to identify the gene mutations responsible for three cases of XLH and its clinical phenotype.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2017-0451_s_998_w2aab3b7c14b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a genetic diagnosis and clinical phenotypic linkage analysis of three pedigrees with XLH. Three probands finally diagnosed as XLH were analyzed by next-generation sequencing (NGS). Sanger sequencing was used for mutation scanning in other family members.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2017-0451_s_997_w2aab3b7c14b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>For the three patients with XLH, the age of onset ranged from 1.5 to 2 years and their heights were less than three standard deviations (SDs) below the median. The patients exhibited curved deformities in both lower limbs, hypophosphatemia, elevated serum FGF23 levels and elevated levels of blood alkaline phosphatase, with normal levels of blood parathyroid hormone (PTH) and calcium. X-ray analysis of the limbs and chest revealed characteristic rickets signs. Three candidate pathogenic mutations were identified in <jats:italic>PHEX<\/jats:italic> (NM_000444.5): c.433G&gt;T (p.Glu145*, p.E145*) in exon 4, c.1735G&gt;A (p.Gly579Arg, p.G579R) (rs875989883) in exon 17 and c.2245T&gt;C (p.Trp749Arg, p.W749R) in exon 22. The nonsense mutation (p.E145*) in <jats:italic>PHEX<\/jats:italic> is novel and is predicted to cause a truncation of the encoded protein, resulting in loss of function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2017-0451_s_996_w2aab3b7c14b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The novel nonsense mutation (p.E145*) in <jats:italic>PHEX<\/jats:italic> is possibly involved in inherited XLH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2017-0451","type":"journal-article","created":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T22:16:58Z","timestamp":1527977818000},"page":"789-797","source":"Crossref","is-referenced-by-count":8,"title":["Genetic analysis of three families with X-linked dominant hypophosphatemic rickets"],"prefix":"10.1515","volume":"31","author":[{"given":"Xinfu","family":"Lin","sequence":"first","affiliation":[{"name":"Provincial Clinical Medical College , Fujian Medical University , Fuzhou , P.R. China"},{"name":"Department of Paediatrics , Fujian Provincial Hospital , Fuzhou , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaobin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine , The First Affiliated Hospital , Fujian Medical University , Fuzhou , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4271-4848","authenticated-orcid":false,"given":"Jiewei","family":"Luo","sequence":"additional","affiliation":[{"name":"Provincial Clinical Medical College , Fujian Medical University , Fuzhou , P.R. China"},{"name":"Department of Traditional Chinese Medicine , Fujian Provincial Hospital , Fuzhou , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbin","family":"Huang","sequence":"additional","affiliation":[{"name":"Provincial Clinical Medical College , Fujian Medical University , Fuzhou , P.R. China"},{"name":"Department of Traditional Chinese Medicine , Fujian Provincial Hospital , Fuzhou , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,6,2]]},"reference":[{"key":"2023040100083356637_j_jpem-2017-0451_ref_001_w2aab3b7c14b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Fuente R, Gil-Pe\u00f1a H, Claramunt-Taberner D, Hern\u00e1ndez O, Fern\u00e1ndez-Iglesias A, et al. X-linked hypophosphatemia and growth. Rev Endocr Metab Disord 2017;18:107\u201315.","DOI":"10.1007\/s11154-017-9408-1"},{"key":"2023040100083356637_j_jpem-2017-0451_ref_002_w2aab3b7c14b1b6b1ab2b1b2Aa","unstructured":"Fadavi S, Rowold E. Familial hypophosphatemic vitamin D-resistant rickets: review of the literature and report of case. 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