{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:14:29Z","timestamp":1792271669871,"version":"4.4.0"},"reference-count":15,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2017-0485_s_999_w2aab3b7c35b1b6b1aab1c16b1Aa\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Amiodarone-induced thyrotoxicosis (AIT) type 2, characterized as a destructive thyroiditis, is well described in the medical literature; however, iodine-induced thyrotoxicosis (IIT) is not, though the latter has similar features and can be managed similarly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2017-0485_s_998_w2aab3b7c35b1b6b1aab1c16b2Aa\">\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>\n                      We present a 17-year-old female who presented with a history of an intermittent goiter with thyroid function tests (TFTs): thyroid-stimulating hormone (TSH)&lt;0.015 (0.4\u20134 \u03bcU\/mL), free thyroxine (T4)\u22656 (0.7\u20132.1 ng\/dL) and total triiodothyronine (T3) 651 (50\u2013200 mg\/dL). Thyroid antibodies were all negative. Despite methimazole therapy for 6 weeks, hyperthyroidism proved refractory to medical management.\n                      <jats:sup>123<\/jats:sup>\n                      I scan uptake was suppressed. With hyperthyroidism being recalcitrant to therapy, a nutritional history revealed consumption of an iodine supplement containing at least 7 times the recommended daily allowance (RDA) for 5 years, contributing to the Jod-Basedow phenomenon. Urinary spot and 24-hour urinary iodine were both elevated. Though a surgical consult was obtained, surgery was cancelled once TFTs improved and then normalized with steroid therapy. The TFTs and urinary iodine levels remained normal post steroid therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2017-0485_s_997_w2aab3b7c35b1b6b1aab1c16b3Aa\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We suggest that in addition to the need for a thorough nutritional history, a trial of corticosteroids should be utilized in the management of IIT which can present with findings similar to AIT type 2 which is recalcitrant to thionamide therapy. If successful, corticosteroids may delay or prevent surgical management thus avoiding possible complications with the latter approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2017-0485","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T05:48:39Z","timestamp":1519710519000},"page":"585-588","source":"Crossref","is-referenced-by-count":8,"title":["In iodine-induced thyrotoxicosis, steroid therapy today could keep the surgical knife at bay"],"prefix":"10.1515","volume":"31","author":[{"given":"Rohan K.","family":"Henry","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics , Nationwide Children\u2019s Hospital\/The Ohio State University College of Medicine , Columbus, OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Chaudhari","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics , Nationwide Children\u2019s Hospital\/The Ohio State University College of Medicine , Columbus, OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"2021021322190205169_j_jpem-2017-0485_ref_001_w2aab3b7c35b1b6b1ab2b1b1Aa","unstructured":"Cooper DS, Ladenson PW. 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