{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:49:17Z","timestamp":1777654157865,"version":"3.51.4"},"reference-count":10,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2017-0554_s_999_w2aab3b7c47b1b6b1aab1c16b1Aa\">\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>In this case report, we present a preterm newborn with persistent lactic acidosis who received total parenteral nutrition (TPN) that lacked thiamine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2017-0554_s_998_w2aab3b7c47b1b6b1aab1c16b2Aa\">\n                  <jats:title>Case presentation:<\/jats:title>\n                  <jats:p>A 28-week-old, 750 g female infant was born with an Apgar score of 8 at the 5th minute. Umbilical cord blood gas levels, including lactate level, were normal, and she was admitted to our neonatal intensive care unit (NICU). Achieving full enteral feeding was not possible due to gastric residues and abdominal distention, making the patient dependent on TPN during the first 2 weeks of life. An insidious increase in lactic acid levels and uncompensated metabolic acidosis were apparent from the 23rd day of life. Severe metabolic acidosis was persistent despite massive doses of bicarbonate. The acidosis resolved dramatically within 6 h when the patient was administered with thiamine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2017-0554_s_997_w2aab3b7c47b1b6b1aab1c16b3Aa\">\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Although TPN is life saving in the NICU, meticulous attention must be paid to provide all essential macro- and micro-nutrients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2017-0554","type":"journal-article","created":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T22:16:39Z","timestamp":1525212999000},"page":"693-695","source":"Crossref","is-referenced-by-count":10,"title":["Severe lactic acidosis in an extremely low birth weight infant due to thiamine deficiency"],"prefix":"10.1515","volume":"31","author":[{"given":"Hulya","family":"Ozdemir","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology , T.C. Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131-Marmara \u00dcniversitesi Pendik E\u011fitim ve Ara\u015ft\u0131rma Hastanesi, Fevzi \u00c7akmak Mah. Mimar Sinan Cad. \u00dcstkaynarca , Pendik, Istanbul 3489 , Turkey , Phone: +90 216 625 45 45\/0 533 351 83 45, Fax: +90 216 657 06 95"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hulya","family":"Bilgen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology , Marmara University Faculty of Medicine , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Alp Unkar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology , Marmara University Faculty of Medicine , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ertugrul","family":"Kiykim","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Metabolism, Department of Pediatrics , Cerrahpasa Medical Faculty, Istanbul University , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asli","family":"Memisoglu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology , Marmara University Faculty of Medicine , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eren","family":"Ozek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology , Marmara University Faculty of Medicine , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,5,1]]},"reference":[{"key":"2025013009594734899_j_jpem-2017-0554_ref_001_w2aab3b7c47b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Hanson C, Thoene M, Wagner J, Collier D, Lecci K, et al. Parenteral nutrition additive shortages: the short-term, long-term and potential epigenetic implications in premature and hospitalized infants. Nutrients 2012;4:1977\u201388.","DOI":"10.3390\/nu4121977"},{"key":"2025013009594734899_j_jpem-2017-0554_ref_002_w2aab3b7c47b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Pichard C, Thibault R, Heidegger CP, Genton L. Enteral and parenteral nutrition for critically ill patients: a logical combination to optimize nutritional support. Clin Nutr Suppl 2009;4:3\u20137.","DOI":"10.1016\/j.clnu.2009.04.007"},{"key":"2025013009594734899_j_jpem-2017-0554_ref_003_w2aab3b7c47b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Oguz SS, Ergenekon E, T\u00fcmer L, Ko\u00e7 E, Turan O, et al. A rare case of severe lactic acidosis in a preterm infant: lack of thiamine during total parenteral nutrition. 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