{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:50:20Z","timestamp":1765486220115,"version":"3.41.0"},"reference-count":8,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpem-2018-0171_s_999_w2aab3b7c63b1b6b1aab1c15b1Aa\"><jats:title>Background<\/jats:title><jats:p>Hypertriglyceridemia thalassemia syndrome is a rare entity with an unknown pathogenetic link.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2018-0171_s_998_w2aab3b7c63b1b6b1aab1c15b2Aa\"><jats:title>Case presentation<\/jats:title><jats:p>We report a case of an 8-month-old female with thalassemia major and increased triglyceride (TG) levels. The clinical features were as in classical thalassemia except for a white discoloration of the plasma. After exclusion of familial triglyceridemia and secondary causes (hypothyroidism, nephrotic syndrome, drugs etc.), a diagnosis of hypertriglyceridemia thalassemia syndrome was made.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2018-0171_s_997_w2aab3b7c63b1b6b1aab1c15b3Aa\"><jats:title>Conclusions<\/jats:title><jats:p>The high levels of TG in these patients are associated with oxidative stress and higher risk of acute pancreatitis and coronary diseases. An early recognition is thus essential. In our patient, the levels reduced after a transfusion therapy similar to previous reports.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2018-0171","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T22:16:06Z","timestamp":1529014566000},"page":"821-822","source":"Crossref","is-referenced-by-count":6,"title":["Hypertriglyceridemia thalassemia syndrome"],"prefix":"10.1515","volume":"31","author":[{"given":"Mili","family":"Jain","sequence":"first","affiliation":[{"name":"Assistant Professor, Department of Pathology , King George\u2019s Medical University , Lucknow 226003 , India , Phone: +9793546090, Fax: +0522-2257580, E-mail:"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wahid","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pathology , King George\u2019s Medical University , Lucknow , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brijendra Bahadur","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology , King George\u2019s Medical University , Lucknow , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishant","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , King George\u2019s Medical University , Lucknow , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashutosh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology , King George\u2019s Medical University , Lucknow , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,6,14]]},"reference":[{"key":"2023040100083362043_j_jpem-2018-0171_ref_001_w2aab3b7c63b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Khera R, Singh M, Goel G, Gupta P, Singh T, et al. Hypertriglyceridemia thalassemia syndrome: a report of 4 cases. Indian J Hematol Blood Transfus 2014;30(Suppl 1):S288\u201391.","DOI":"10.1007\/s12288-014-0362-8"},{"key":"2023040100083362043_j_jpem-2018-0171_ref_002_w2aab3b7c63b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Das L, Samprathi M, Shukla U, Bandyopadhyay D, Das RR. Hypertriglyceridemia thalassemia syndrome: common disease, uncommon association. Indian J Pediatr 2016;83:720\u20132.","DOI":"10.1007\/s12098-016-2062-x"},{"key":"2023040100083362043_j_jpem-2018-0171_ref_003_w2aab3b7c63b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Rao S, Kar R, Gupta SK, Chopra A, Saxena R. Spectrum of hemoglobinopathies diagnosed by cation exchange HPLC & modulating effects of nutritional deficiency anaemias from North India. 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