{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T21:05:27Z","timestamp":1762808727786},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpem-2018-0188_s_999_w2aab3b7c18b1b6b1aab1c16b1Aa\"><jats:title>Background<\/jats:title><jats:p>Bartter syndrome is a group of rare autosomal-recessive renal disorders characterized by hypokalemic hypochloremic metabolic alkalosis associated with severe growth failure; the exact causes for growth retardation are unclear. GH deficiency (GHD) has been reported in a few cases of Bartter syndrome. The aim of our study was to determine the prevalence of GHD in children with antenatal Bartter syndrome and to assess their response to GH therapy.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2018-0188_s_998_w2aab3b7c18b1b6b1aab1c16b2Aa\"><jats:title>Methods<\/jats:title><jats:p>Ten patients aged 1.5\u201314.5 years and diagnosed with antenatal Bartter syndrome were enrolled. Seven children with short stature underwent GH stimulation tests.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2018-0188_s_997_w2aab3b7c18b1b6b1aab1c16b3Aa\"><jats:title>Results<\/jats:title><jats:p>Common presenting symptoms were failure to thrive and polyuria. The mean patient height at study entry was \u22122.7 standard deviation (SD) (range 0.89 to \u22125.95) and mean weight (SD) was \u22121.7 (range 1.89 to \u22124.11). A decline in height and weight (SD) was observed over the years. GHD was diagnosed in four children and GH therapy was started in all of them. Two patients responded very well and gained &gt;1 SD in height, one patient stopped therapy due to non-adherence and one had a poor response.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2018-0188_s_996_w2aab3b7c18b1b6b1aab1c16b4Aa\"><jats:title>Conclusions<\/jats:title><jats:p>In addition to other important causes for poor growth in antenatal Bartter syndrome, our findings suggest that GHD should also be considered as a cause of growth retardation and therefore, clinical assessment of the GH axis is recommended. GH therapy has a role in the treatment of growth failure in some individuals with Bartter syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2018-0188","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T09:02:06Z","timestamp":1551949326000},"page":"225-231","source":"Crossref","is-referenced-by-count":5,"title":["Growth hormone deficiency in children with antenatal Bartter syndrome"],"prefix":"10.1515","volume":"32","author":[{"given":"Inna","family":"Spector-Cohen","sequence":"first","affiliation":[{"name":"Pediatric Nephrology Unit , Ha\u2019 Emek Medical Center , Afula , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel","family":"Koren","sequence":"additional","affiliation":[{"name":"Pediatric Department B , Ha\u2019 Emek Medical Center , Afula , Israel"},{"name":"Rappaport Faculty of Medicine , Technion Institute of Technology , Haifa , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waheeb","family":"Sakran","sequence":"additional","affiliation":[{"name":"Pediatric Department B , Ha\u2019 Emek Medical Center , Afula , Israel"},{"name":"Rappaport Faculty of Medicine , Technion Institute of Technology , Haifa , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yardena","family":"Tenenbaum-Rakover","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine , Technion Institute of Technology , Haifa , Israel"},{"name":"Pediatric Endocrinology Institute , Ha\u2019Emek Medical Center , Afula 1834111 , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rephael","family":"Halevy","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Unit , Ha\u2019 Emek Medical Center , Afula , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"2021021320260352045_j_jpem-2018-0188_ref_001_w2aab3b7c18b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Jeck N, Schlingmann KP, Reinalter SC, K\u00f6mhoff M, Peters M, et al. 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