{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:16:29Z","timestamp":1790622989763,"version":"4.1.0"},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2018-0192_s_999_w2aab2b8b4b1b7b1aab1c16b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Type-1 diabetes mellitus (T1DM) causes endothelial dysfunction and early atherosclerosis, which can result in premature coronary artery disease. The aim of this study was to determine the impact of glycemic control, vascular oxidative stress and inflammation on vascular health in adolescents with T1DM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2018-0192_s_998_w2aab2b8b4b1b7b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a cross-sectional study in adolescents with age- and sex-matched T1DM who were \u226512 years and were at least 2 years post-diagnosis. Recruitment was balanced to include individuals with hemoglobin A<jats:sub>1c<\/jats:sub> (HbA<jats:sub>1c<\/jats:sub>) \u22648.5% (n=27) or with HbA<jats:sub>1c<\/jats:sub> \u22659.5% (n=25). Biomarkers of inflammation were measured in the blood including C-reactive protein (CRP), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), E-selectin, fibrinogen and tumor necrosis factor-\u03b1 (TNF-\u03b1). Carotid intima media thickness (cIMT) and peripheral arterial tonometry (PAT) were assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2018-0192_s_997_w2aab2b8b4b1b7b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Plasma E-selectin level was significantly different between the two groups with higher levels in the group with HbA<jats:sub>1c<\/jats:sub> \u22659.5% (65.0\u00b127.7 ng\/mL vs. 48.8\u00b121.5 ng\/mL, p=0.02). Though cIMT and PAT were not significantly different between the groups, Pearson correlation showed a significant direct relationship between rising HbA<jats:sub>1c<\/jats:sub> and mean right cIMT (p=0.02; r=0.37), PAT (p=0.03, r=0.31) and fibrinogen (p=0.03, r=0.03).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2018-0192_s_996_w2aab2b8b4b1b7b1aab1c16b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Elevated E-selectin level is an early marker of oxidative stress in T1DM patients with an elevated HbA<jats:sub>1c<\/jats:sub> level. Suboptimal glycemic control as evidenced by a rising HbA<jats:sub>1c<\/jats:sub> causes early atherosclerosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2018-0192","type":"journal-article","created":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T09:02:06Z","timestamp":1549098126000},"page":"109-113","source":"Crossref","is-referenced-by-count":23,"title":["Assessment of biomarkers of inflammation and premature atherosclerosis in adolescents with type-1 diabetes mellitus"],"prefix":"10.1515","volume":"32","author":[{"given":"Ghufran","family":"Babar","sequence":"first","affiliation":[{"name":"Children\u2019s Mercy Hospitals and Clinics , Kansas City, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Clements","sequence":"additional","affiliation":[{"name":"Children\u2019s Mercy Hospitals and Clinics , Kansas City, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Dai","sequence":"additional","affiliation":[{"name":"Children\u2019s Mercy Hospitals and Clinics , Kansas City, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Raghuveer","sequence":"additional","affiliation":[{"name":"Children\u2019s Mercy Hospitals and Clinics , Kansas City, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,2,2]]},"reference":[{"key":"2023040100395065575_j_jpem-2018-0192_ref_001_w2aab2b8b4b1b7b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Singh TP, Groehn H, Kazmers A. 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