{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:31:42Z","timestamp":1773426702711,"version":"3.50.1"},"reference-count":11,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2018-0210_s_999_w2aab3b7b9b1b6b1aab1c16b1Aa\">\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Gonadotropin-releasing hormone agonists (GnRH-a) are common treatment options for central precocious puberty (CPP) in childhood. GnRH-a treatment is useful and has a good safety profile, with minimal adverse effects and no severe long-term consequences. The common side effects in children are menopause-like symptoms and local adverse events at the injection site.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2018-0210_s_998_w2aab3b7b9b1b6b1aab1c16b2Aa\">\n                  <jats:title>Case presentation:<\/jats:title>\n                  <jats:p>We present the case of a girl with CPP who developed arterial hypertension from treatment with GnRH-a (triptorelin). Comprehensive diagnostic studies ruled out other causes for her hypertension and its complications. After therapy was interrupted, her blood pressure remained within normal limits for age. Consequently, we hypothesize that the hypertension presented by our patient was related to triptorelin treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2018-0210_s_997_w2aab3b7b9b1b6b1aab1c16b3Aa\">\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Although the etiology of this adverse event is not known and only some hypotheses can be made, clinicians should be aware that arterial hypertension might appear during triptorelin treatment in childhood with CPP. Therefore, they should routinely monitor the arterial blood pressure of patients under treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2018-0210","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T07:23:41Z","timestamp":1533799421000},"page":"449-452","source":"Crossref","is-referenced-by-count":9,"title":["Does the risk of arterial hypertension increase in the course of triptorelin treatment?"],"prefix":"10.1515","volume":"33","author":[{"given":"Laura","family":"Palma","sequence":"first","affiliation":[{"name":"Pediatric Division, Department of Pediatrics , University Hospital of Verona , Verona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Gaudino","sequence":"additional","affiliation":[{"name":"Pediatric Division, Department of Pediatrics , University Hospital of Verona , Verona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Cavarzere","sequence":"additional","affiliation":[{"name":"Pediatric Division, Department of Pediatrics , University Hospital of Verona , Verona , Italy"},{"name":"Department of Pediatrics , Child and Mother\u2019s Hospital, Piazzale Stefani 1 , Verona 37126 , Italy , Phone: +39 045 8127811, Fax: +39 045 8127810"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Antoniazzi","sequence":"additional","affiliation":[{"name":"Pediatric Division, Department of Pediatrics , University Hospital of Verona , Verona , Italy"},{"name":"Regional Center for the Diagnosis and Treatment of Children and Adolescents Rare Skeletal Disorders, Pediatric Clinic, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics , University of Verona , Verona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,8,8]]},"reference":[{"key":"2023040101053360581_j_jpem-2018-0210_ref_001_w2aab3b7b9b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Latronico AC, Brito VN, Carel JC. Causes, diagnosis, and treatment of central precocious puberty. Lancet Diabetes Endocrinol 2016;4:265\u201374.","DOI":"10.1016\/S2213-8587(15)00380-0"},{"key":"2023040101053360581_j_jpem-2018-0210_ref_002_w2aab3b7b9b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Carel JC, L\u00e9ger J. Clinical practice. Precocious puberty. N Engl J Med 2008;358:2366\u201377.","DOI":"10.1056\/NEJMcp0800459"},{"key":"2023040101053360581_j_jpem-2018-0210_ref_003_w2aab3b7b9b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Carel JC, Eugster EA, Rogol A, Ghizzoni L, Palmert MR, et al. Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics 2009;123:e752\u201362.","DOI":"10.1542\/peds.2008-1783"},{"key":"2023040101053360581_j_jpem-2018-0210_ref_004_w2aab3b7b9b1b6b1ab2b1b4Aa","doi-asserted-by":"crossref","unstructured":"Antoniazzi F, Zamboni G. Central precocious puberty: current treatment options. Paediatr Drugs 2004;6:211\u201331.","DOI":"10.2165\/00148581-200406040-00002"},{"key":"2023040101053360581_j_jpem-2018-0210_ref_005_w2aab3b7b9b1b6b1ab2b1b5Aa","doi-asserted-by":"crossref","unstructured":"Tonini G, Lazzerini M. Side effects of GnRH analogue treatment in childhood. J Pediatr Endocrinol Metab 2000;13:795\u2013803.","DOI":"10.1515\/JPEM.2000.13.S1.795"},{"key":"2023040101053360581_j_jpem-2018-0210_ref_006_w2aab3b7b9b1b6b1ab2b1b6Aa","doi-asserted-by":"crossref","unstructured":"Lurbe E, Agabiti-Rosei E, Cruickshank JK, Dominiczak A, Erdine S, et al. 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents. J Hypertens 2016;34:1887\u2013920.","DOI":"10.1097\/HJH.0000000000001039"},{"key":"2023040101053360581_j_jpem-2018-0210_ref_007_w2aab3b7b9b1b6b1ab2b1b7Aa","doi-asserted-by":"crossref","unstructured":"Calcaterra V, Mannarino S, Corana G, Codazzi AC, Mazzola A, et al. Hypertension during therapy with triptorelin in a girl with precocious puberty. Indian J Pediatr 2013;80:884\u20135.","DOI":"10.1007\/s12098-012-0898-2"},{"key":"2023040101053360581_j_jpem-2018-0210_ref_008_w2aab3b7b9b1b6b1ab2b1b8Aa","doi-asserted-by":"crossref","unstructured":"Siomou E, Kosmeri C, Pavlou M, Vlahos AP, Argyropoulou MI, et al. Arterial hypertension during treatment with triptorelin in a child with Williams-Beuren syndrome. Pediatr Nephrol 2014;29:1633\u20136.","DOI":"10.1007\/s00467-014-2795-6"},{"key":"2023040101053360581_j_jpem-2018-0210_ref_009_w2aab3b7b9b1b6b1ab2b1b9Aa","doi-asserted-by":"crossref","unstructured":"Albaladejo Blanco C, Garc\u00eda Vicente JA, Garc\u00eda-Faria Rialp F. Hypertension crisis as a side effect of triptorelin? Aten Primaria 2004;34:566\u20137.","DOI":"10.1016\/S0212-6567(04)70866-5"},{"key":"2023040101053360581_j_jpem-2018-0210_ref_010_w2aab3b7b9b1b6b1ab2b1c10Aa","doi-asserted-by":"crossref","unstructured":"Acs N, Szekacs B, Nadasy GL, Varbiro S, Kakucs R, et al. The effect of ovariectomy and oestrogen replacement on small artery biomechanics in the rat. Br J Obstet Gynaecol 1999;106:148\u201354.","DOI":"10.1111\/j.1471-0528.1999.tb08215.x"},{"key":"2023040101053360581_j_jpem-2018-0210_ref_011_w2aab3b7b9b1b6b1ab2b1c11Aa","doi-asserted-by":"crossref","unstructured":"Rosner B, Cook NR, Daniels S, Falkner B. Childhood blood pressure trends and risk factors for high blood pressure: the NHANES experience 1988\u20132008. Hypertension 2013;62:247\u201354.","DOI":"10.1161\/HYPERTENSIONAHA.111.00831"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/jpem\/33\/3\/article-p449.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2018-0210\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2018-0210\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T17:58:11Z","timestamp":1680371891000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2018-0210\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,8]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,2,17]]},"published-print":{"date-parts":[[2020,3,26]]}},"alternative-id":["10.1515\/jpem-2018-0210"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2018-0210","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8,8]]}}}