{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:25:21Z","timestamp":1779233121292,"version":"3.51.4"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2018-0307_s_999_w2aab3b7c29b1b6b1aab1c15b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Neonatal severe hyperparathyroidism (NSHPT) is commonly treated with either parathyroidectomy or pharmacologic agents with varying efficacy and numerous side effects. Reports of using cinacalcet for NSHPT have increased, however, the effective dose for pediatric patients from the onset of symptoms through infancy has not been established.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2018-0307_s_998_w2aab3b7c29b1b6b1aab1c15b2Aa\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>We describe the clinical course of a newborn with a <jats:italic>de novo<\/jats:italic> R185Q mutation in the calcium-sensing receptor (<jats:italic>CASR<\/jats:italic>) gene, causing NSHPT. The infant received cinacalcet from the first days of life until 1 year of age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2018-0307_s_997_w2aab3b7c29b1b6b1aab1c15b3Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Cinacalcet therapy effectively controlled the patient\u2019s serum calcium, phosphorus, and parathyroid hormone (PTH) levels without side effects.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2018-0307","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T09:03:06Z","timestamp":1549530186000},"page":"305-310","source":"Crossref","is-referenced-by-count":13,"title":["Cinacalcet therapy in an infant with an R185Q calcium-sensing receptor mutation causing hyperparathyroidism: a case report and review of the literature"],"prefix":"10.1515","volume":"32","author":[{"given":"Thomas E.","family":"Forman","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Perioperative, and Pain Medicine , Stanford University School of Medicine , Stanford, CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna-Kaisa","family":"Niemi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatal and Developmental Medicine , Stanford University School of Medicine , Stanford, CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Prahalad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Endocrinology , Stanford University School of Medicine , Stanford, CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Run Zhang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology , Stanford University , Stanford, CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M.","family":"Nally","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Endocrinology , Stanford University School of Medicine , Stanford, CA , USA"},{"name":"Department of Pediatrics, Division of Pediatric Endocrinology , Yale School of Medicine , 333 Cedar Street, LMP 3103E, P.O. Box 208064 , New Haven, CT 06520 , USA , Phone: 203-785-5809, Fax: 203-764-9149"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"2021021320255628284_j_jpem-2018-0307_ref_001_w2aab3b7c29b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Brown EM. Physiology and pathophysiology of the extracellular calcium-sensing receptor. Am J Med 1999;106:238\u201353.","DOI":"10.1016\/S0002-9343(98)00418-5"},{"key":"2021021320255628284_j_jpem-2018-0307_ref_002_w2aab3b7c29b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Brown EM. Editorial: mutant extracellular calcium-sensing receptors and severity of disease. J Clin Endocrinol Metab 2005;90:1246\u20138.","DOI":"10.1210\/jc.2004-2483"},{"key":"2021021320255628284_j_jpem-2018-0307_ref_003_w2aab3b7c29b1b6b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Hofer AM, Brown EM. Extracellular calcium sensing and signalling. 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