{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:18:41Z","timestamp":1778879921846,"version":"3.51.4"},"reference-count":98,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpem-2018-0346_s_999\"><jats:title id=\"d2783957e9766\">Background<\/jats:title><jats:p>Females with Turner syndrome (TS) carry an elevated risk of aortic dissection. The objective of the study was to assess the biophysical properties of the aorta and ambulatory blood pressure (BP) in females with TS and compare these findings to those in healthy female age-matched controls.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2018-0346_s_998\"><jats:title id=\"d2783957e9774\">Methods<\/jats:title><jats:p>This was a prospective cohort study including subjects aged 8\u201325 years. Utilizing two-dimensional (2D) echocardiography and Doppler, proximal aortic dimensions were measured and biophysical properties of the aorta were calculated including pulse wave velocity (PWV), arterial pressure-strain elastic modulus and stiffness index. Resting BP was measured and ambulatory blood pressure monitoring (ABPM) was performed.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2018-0346_s_997\"><jats:title id=\"d2783957e9782\">Results<\/jats:title><jats:p>Of 23 TS patients and 46 controls (median age 16.3 years), aortic annulus, sinus of Valsalva and sinotubular (ST) junction diameters, as well as left ventricular (LV) mass, were significantly greater in TS patients compared with controls when scaled for height<jats:sup>2.7<\/jats:sup>, but not for body surface area (BSA), although ascending aorta diameter was greater when scaled for both. Median PWV was faster in TS patients compared to controls (451 vs. 360 cm\/s) while arterial pressure-strain elastic modulus and stiffness index were similar. Resting BP was abnormal in seven out of 22 patients and ABPM was abnormal in 16 out of 21 patients.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2018-0346_s_996\"><jats:title id=\"d2783957e9793\">Conclusions<\/jats:title><jats:p>Young patients with TS had dilated proximal aortas when scaled for height<jats:sup>2.7<\/jats:sup>and stiffer aortas when compared with healthy female age-matched controls. Moreover, resting BP underdiagnosed pre-hypertension and hypertension compared to ABPM. These findings are consistent with the presence of a primary aortopathy in TS.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2018-0346","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T09:02:30Z","timestamp":1556701350000},"page":"489-498","source":"Crossref","is-referenced-by-count":9,"title":["Non-invasive assessment of aortic stiffness and blood pressure in young Turner syndrome patients"],"prefix":"10.1515","volume":"32","author":[{"given":"Danya A.","family":"Fox","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristopher T.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Potts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura L.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janis M.","family":"Dionne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George G.S.","family":"Sandor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref981","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jpeds.2016.04.080","article-title":"Cardiac magnetic resonance imaging in pediatric Turner syndrome","volume":"175","year":"2016","journal-title":"J Pediatr"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jjcc.2016.03.006","article-title":"Increased aortic stiffness in prepubertal girls with Turner 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