{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:57:38Z","timestamp":1781650658293,"version":"3.54.5"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,19]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Although hepatic infantile hemangioma (IH) may correlate with consumptive hypothyroidism consequent to the overexpression of thyroid hormone inactivating enzyme by hemangioma cells, hypothyroidism has been rarely recognized in infants with cutaneous hemangioma.<\/jats:p><\/jats:sec>Case presentation<\/jats:title>A male infant born at 28 weeks of gestational age with an extremely low birth weight (775 g) developed a massive cutaneous hemangioma on his neck and severe abdominal distension. Imaging examinations detected a small mass lesion in the brain but no hepatic hemangioma. Laboratory findings at the age of 26 days revealed hypothyroidism. Although high-dose levothyroxine therapy failed to normalize the thyroid function, hypothyroidism improved and cutaneous hemangioma regressed after initiating propranolol therapy.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our findings suggest that consumptive hypothyroidism should be considered as a critical comorbidity in patients with massive cutaneous IH. Propranolol therapy can effectively normalize thyroid function and cause hemangioma regression.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2018-0369","type":"journal-article","created":{"date-parts":[[2018,10,27]],"date-time":"2018-10-27T09:08:08Z","timestamp":1540631288000},"page":"1377-1380","source":"Crossref","is-referenced-by-count":8,"title":["A case of an infant with extremely low birth weight and hypothyroidism associated with massive cutaneous infantile hemangioma"],"prefix":"10.1515","volume":"31","author":[{"given":"Aiko","family":"Igarashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikue","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miori","family":"Yuasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Okuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusei","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref111","doi-asserted-by":"crossref","first-page":"e27280","DOI":"10.1002\/pbc.27280","article-title":"Propranolol versus steroids for the treatment of ulcerated infantile hemangiomas","volume":"65","year":"2018","journal-title":"Pediatr Blood 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