{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:25:27Z","timestamp":1769635527698,"version":"3.49.0"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"2","funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/03236\u20135"],"award-info":[{"award-number":["2013\/03236\u20135"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2018-0435_s_999_w2aab2b8c55b1b7b1aab1c16b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>When evaluating peripubertal short stature patients, the interpretation of insulin-like growth factor 1 (IGF-1) levels based on chronological age (CA) can be inaccurate due to the influence of sex steroids and, presently, there is no evidence to support the assessment of IGF-1 values according to bone age (BA) and pubertal status (PS). Our objective was to assess the discriminatory performance of IGF-1 levels based on CA, BA and PS in the diagnosis of growth hormone (GH) deficiency.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2018-0435_s_998_w2aab2b8c55b1b7b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We evaluated IGF-1 levels from 154 peripubertal short stature patients classified as GH deficient (GHD, n=23) or non-GHD (n=131). IGF-1 was assayed by a chemiluminescent immunometric assay and transformed into standard deviation scores (SDS) according to CA (IGF-1-SDS-CA), BA (IGF-1-SDS-BA) and PS (IGF-1-SDS-PS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2018-0435_s_997_w2aab2b8c55b1b7b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The performances of IGF-1-SDS-CA, IGF-1-SDS-BA and IGF-1-SDS-PS in the receiver operator characteristics (ROC) curves were similar. There were greater accuracy and specificity of IGF-1-SDS-PS (98.4% and 93.3%, respectively) and IGF-1-SDS-BA (92.7% and 90.1%, respectively) when compared to IGF-1-SDS-CA (65.6% and 69.5%, respectively). The post-test probability of the IGF-1-SDS was also improved when compared to PS and BA \u2013 44.8% (IGF-1-SDS-PS), 16.8% (IGF-1-SDS-BA) and 5.1% (IGF-1-SDS-CA), with similar negative predictive values.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2018-0435_s_996_w2aab2b8c55b1b7b1aab1c16b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The evaluation of IGF-1 levels based on CA has a higher sensitivity than those based on BA or PS, which justify its use as a screening tool. Additionally, IGF-1 assessed by PS has the best positive predictive power for GHD diagnosis in peripubertal age and could reduce the necessity of a second GH stimulation test.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2018-0435","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T09:03:06Z","timestamp":1549530186000},"page":"173-179","source":"Crossref","is-referenced-by-count":25,"title":["IGF-1 assessed by pubertal status has the best positive predictive power for GH deficiency diagnosis in peripubertal children"],"prefix":"10.1515","volume":"32","author":[{"given":"Thais H.","family":"Inoue-Lima","sequence":"first","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento (LIM\/42), Hospital das Clinicas da Faculdade de Medicina , Universidade de Sao Paulo (USP) , Sao Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela A.","family":"Vasques","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento (LIM\/42), Hospital das Clinicas da Faculdade de Medicina , Universidade de Sao Paulo (USP) , Sao Paulo , Brazil"},{"name":"Unidade de Endocrinologia Genetica (LIM\/25), Hospital das Clinicas da Faculdade de Medicina , Universidade de Sao Paulo (USP) , Sao Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata C.","family":"Scalco","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento (LIM\/42), Hospital das Clinicas da Faculdade de Medicina , Universidade de Sao Paulo (USP) , Sao Paulo , Brazil"},{"name":"Unidade de Endocrinologia Genetica (LIM\/25), Hospital das Clinicas da Faculdade de Medicina , Universidade de Sao Paulo (USP) , Sao Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilena","family":"Nakaguma","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento (LIM\/42), Hospital das Clinicas da Faculdade de Medicina , Universidade de Sao Paulo (USP) , Sao Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berenice B.","family":"Mendonca","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento (LIM\/42), Hospital das Clinicas da Faculdade de Medicina , Universidade de Sao Paulo (USP) , Sao Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo J.P.","family":"Arnhold","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento (LIM\/42), Hospital das Clinicas da Faculdade de Medicina , Universidade de Sao Paulo (USP) , Sao Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander A.L.","family":"Jorge","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia Genetica (LIM\/25), Hospital das Clinicas da Faculdade de Medicina , Universidade de Sao Paulo (USP), Faculdade de Medicina da USP (LIM-25) , Av. Dr. Arnaldo, 455 5\u00b0 andar sala 5340 , CEP 01246-903 Sao Paulo, SP , Brazil"},{"name":"Unidade de Endocrinologia do Desenvolvimento (LIM\/42), Hospital das Clinicas da Faculdade de Medicina , Universidade de Sao Paulo (USP) , Sao Paulo , Brazil , Phone\/Fax: +55-11-3061-7252"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"2023040100395062497_j_jpem-2018-0435_ref_001_w2aab2b8c55b1b7b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Fayter D, Nixon J, Hartley S, Rithalia A, Butler G, et al. Effectiveness and cost-effectiveness of height-screening programmes during the primary school years: A systematic review. Arch Dis Child 2008;93:278\u201384.","DOI":"10.1136\/adc.2006.109843"},{"key":"2023040100395062497_j_jpem-2018-0435_ref_002_w2aab2b8c55b1b7b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Richmond E, Rogol AD. 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