{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T12:21:16Z","timestamp":1753359676778},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpem-2018-0482_s_999_w2aab3b7b2b1b6b1aab1c16b1Aa\"><jats:title>Background<\/jats:title><jats:p>Some studies have examined the effect of gonadal suppression on insulin-like growth factor-1 (IGF-1) levels and the growth velocity (GV) with conflicting results.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2018-0482_s_998_w2aab3b7b2b1b6b1aab1c16b2Aa\"><jats:title>Methods<\/jats:title><jats:p>Forty-four girls treated with gonadotropin-releasing hormone analogue (GnRHa) for central precocious puberty (CPP) were included in the study. IGF-1 levels were examined at the beginning and after 12 months of treatment.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2018-0482_s_997_w2aab3b7b2b1b6b1aab1c16b3Aa\"><jats:title>Results<\/jats:title><jats:p>IGF-1 and IGF-1 standard deviation score (SDS) according to chronological age (CA-IGF-1 SDS) at diagnosis were positively correlated with chronological age (CA), anthropometric measurements, stage of puberty, bone age (BA), BA-CA, follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol, uterus length, endometrium thickness and ovarian volume (OV) at diagnosis (p\u2009&lt;\u20090.05). There was no significant difference in IGF-1 levels after treatment. However, there was a negative correlation between \u0394IGF-1 SDS and IGF-1 level, CA-IGF-1 SDS and BA-IGF-1 SDS at diagnosis (p\u2009&lt;\u20090.05). There was no correlation between GV and IGF-1, \u0394IGF-1. GV was negatively correlated with basal LH level at diagnosis (p\u2009=\u20090.008, r\u2009=\u2009\u22120.397). Peak LH levels of the patients who had GV-SDS\u2009&lt;\u20090 were more suppressive than those of the patients who had GV-SDS\u2009&gt;\u20090 after 12 months of treatment.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2018-0482_s_996_w2aab3b7b2b1b6b1aab1c16b4Aa\"><jats:title>Conclusions<\/jats:title><jats:p>It was determined that the IGF-1 level and CA-IGF-1 SDS at baseline were correlated with more advanced pubertal stage prior to treatment. Initiation of treatment with a relatively high level of IGF-1 increased the risk of a decrease in the IGF-1 level. Likewise, the initiation of treatment with a relatively high LH level may increase the risk of low GV, but low GV was not related to the IGF-1 level. Increased sex steroid suppression may increase the risk of low GV.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2018-0482","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T09:03:08Z","timestamp":1575622988000},"page":"113-120","source":"Crossref","is-referenced-by-count":3,"title":["The alteration of IGF-1 levels and relationship between IGF-1 levels and growth velocity during GnRH analogue therapy"],"prefix":"10.1515","volume":"33","author":[{"given":"Nursel","family":"Muratoglu Sahin","sequence":"first","affiliation":[{"name":"Dr. Sami Ulus Obstetrics and Gynaecology, Paediatric Health and Disease Training and Research Hospital , Paediatric Endocrinology Clinic , Ankara , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Havva Nur","family":"Peltek Kendirci","sequence":"additional","affiliation":[{"name":"Hitit University , Division of Paediatric Endocrinology , Corum , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semra","family":"\u00c7etinkaya","sequence":"additional","affiliation":[{"name":"Dr. Sami Ulus Obstetrics and Gynaecology, Paediatric Health and Disease Training and Research Hospital , Paediatric Endocrinology Clinic , Ankara , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eenay","family":"Sava\u015f Erdeve","sequence":"additional","affiliation":[{"name":"Dr. Sami Ulus Obstetrics and Gynaecology, Paediatric Health and Disease Training and Research Hospital , Paediatric Endocrinology Clinic , Ankara , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra","family":"Aycan","sequence":"additional","affiliation":[{"name":"Dr. Sami Ulus Obstetrics and Gynaecology, Paediatric Health and Disease Training and Research Hospital , Paediatric Endocrinology Clinic , Ankara , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,12,6]]},"reference":[{"key":"2021021317253560369_j_jpem-2018-0482_ref_001_w2aab3b7b2b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Brauner R. Central precocious puberty in girls: prediction of the etiology. J Pediatr Endocrinol Metab 2005;18:845\u20137.","DOI":"10.1515\/JPEM.2005.18.9.845"},{"key":"2021021317253560369_j_jpem-2018-0482_ref_002_w2aab3b7b2b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Weise M, De-Levi S, Barnes KM, Gafni RI, Abad V, et al. Effects of estrogen on growth plate senescence and epiphyseal fusion. Proc Natl Acad Sci USA 2001;98:6871\u20136.","DOI":"10.1073\/pnas.121180498"},{"key":"2021021317253560369_j_jpem-2018-0482_ref_003_w2aab3b7b2b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Byers S, Moore AJ, Byard RW, Fazzalari NL. Quantitative histomorphometric analysis of the human growth plate from birth to adolescence. Bone 2000;27:495\u2013501.","DOI":"10.1016\/S8756-3282(00)00357-4"},{"key":"2021021317253560369_j_jpem-2018-0482_ref_004_w2aab3b7b2b1b6b1ab2b1b4Aa","doi-asserted-by":"crossref","unstructured":"Attie KM, Ramirez NR, Conte FA, Kaplan SL, Grumbach MM. 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