{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:12:16Z","timestamp":1778839936257,"version":"3.51.4"},"reference-count":98,"publisher":"Walter de Gruyter GmbH","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,25]]},"abstract":"Abstract<\/jats:title>\n\nBackground<\/jats:title>\nThe aim of this study was to investigate the effect of 12 weeks of aerobic training, 4 weeks of detraining and use gonadotropin-releasing hormone agonist (GnRHa) on serum C-reactive protein (CRP) and cortisol levels in girls with central precocious puberty (CPP).<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nForty-five girls (aged 6\u20138 years) with precocious puberty were randomly divided into three groups (medication, training and medicine\u2009+\u2009training groups). Fifteen healthy girls (without precocious puberty) were also included as the control group. Serum CRP and cortisol levels were measured at baseline by the enzyme-linked immunosorbent assay (ELISA) technique. Then, the experimental groups performed an aerobic training program for 3 days\/week 20\u201375 min per day at 45\u201375% maximum heart rate for 12 weeks. The medication groups also received GnRHa during the study, once a month (1 mL every 4 weeks) by intramuscular injection. Serum CRP and cortisol levels were measured again 48 h after the last training session and also after 4 weeks of detraining.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nAnalysis of variance (ANOVA) with repeated measures showed a significant decrease in CRP (p\u2009=\u20090.02) and cortisol levels (p\u2009=\u20090.01) in the training group and the medicine\u2009+\u2009training group. Detraining led to return of CRP and cortisol levels to the pre-training levels (p\u2009=\u20090.001). No significant difference in serum CRP (p\u2009=\u20090.43) and cortisol levels (p\u2009=\u20090.06) was observed in the medication group. Further, no significant difference was observed between groups in CRP and cortisol.<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nLong-term regular moderate training decreases inflammation indices, and detraining eliminates the benefits of training in girls with precocious puberty.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2018-0484","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T09:04:00Z","timestamp":1563527040000},"page":"1005-1011","source":"Crossref","is-referenced-by-count":12,"title":["Benefits of aerobic training in girls with precocious puberty: involvement of CRP and 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