{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T07:08:04Z","timestamp":1756192084360},"reference-count":80,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,27]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Testicular adrenal rest tumors (TARTs) leading to primary gonadal failure are the main etiology of infertility in congenital adrenal hyperplasia (CAH). We aimed at identifying the evolution of TART and related findings in young CAH patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Twelve male patients (3\u201323 years old) with 21-hydroxilase deficiency (11 with classic salt-wasting form) were included. Testicular ultrasonography (US) was performed in two moments, by a single blinded specialist in pediatric diagnostic imaging. Tumor progression was classified according to the Response Evaluation Criteria in Solid Tumors (RECIST). The clinical and laboratory data were retrieved from medical records. Serum 17-OH-progesterone (17OHP) and androstenedione concentrations were evaluated during the whole period of follow-up, from the CAH diagnosis. A logistic regression model with repeated measures was developed for the analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>The prevalence of TART was 41.6% (n\u2009=\u20095) in the initial US evaluation and 66.6% (n\u2009=\u20098) after 6 years of follow-up. Tumor progression was detected in 4 of the 5 patients, and 1 presented with a stable tumor. Three patients presented with new tumors in the second evaluation. Most of the patients (n\u2009=\u200911) were pubertal, including a 7-year-old child with TART who presented with central precocious puberty. At regression analysis, it was observed that an inadequate hormonal control led to a 16 times greater chance of a patient to present with TART (OR\u2009=\u200916.08; confidence interval [CI] 95%\u2009=\u20092.38\u2013108.81; p\u2009=\u20090.004).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We found a high prevalence of progressive TART in young pubertal subjects. US testicular screening should help in improving therapeutic optimization in CAH patients to reduce future impairment in fertility.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2018-0512","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T09:02:41Z","timestamp":1557478961000},"page":"519-526","source":"Crossref","is-referenced-by-count":6,"title":["Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia: 6 years of follow-up"],"prefix":"10.1515","volume":"32","author":[{"given":"Gabriela","family":"Werneck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enda M.R.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael M.","family":"Mantovani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovita S.S.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivani N.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref361","doi-asserted-by":"crossref","first-page":"155.e1","DOI":"10.1016\/j.jpurol.2017.11.011","article-title":"Testicular adrenal rest tumor screening and fertility counseling among males with congenital adrenal hyperplasia","volume":"14","year":"2018","journal-title":"J Pediatr Urol"},{"key":"ref531","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1210\/jcem.86.12.8090","article-title":"High prevalence of testicular adrenal rest tumors, impaired spermatogenesis, and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia","volume":"86","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"ref751","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1148\/radiology.198.1.8539414","article-title":"Testicular adrenal rest tissue in congenital adrenal hyperplasia: findings at Gray-scale and color Doppler US","volume":"198","year":"1996","journal-title":"Radiology"},{"key":"ref781","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.juro.2016.09.072","article-title":"Testicular adrenal rest tumors in boys and young adults with congenital adrenal hyperplasia","volume":"197","year":"2017","journal-title":"J Urol"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1007\/s00330-002-1786-3","article-title":"Testicular adrenal rest tumours in postpubertal males with congenital adrenal hyperplasia: sonographic and MR features","volume":"13","year":"2003","journal-title":"Eur Radiol"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1210\/jcem-23-9-861","article-title":"Activation of testicular adrenal rest tissue by prolonged excessive ACTH production","volume":"23","year":"1963","journal-title":"J Clin Endocrinol Metab"},{"key":"ref641","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1210\/jc.2008-1414","article-title":"High prevalence of reduced fecundity in men with congenital adrenal hyperplasia","volume":"94","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1590\/S0004-27302013000200005","article-title":"Final height in congenital adrenal hyperplasia: the dilemma of hypercortisolism versus hyperandrogenism","volume":"57","year":"2013","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1210\/jc.2009-1929","article-title":"Total adrenal volume but not testicular adrenal rest tumor volume is associated with hormonal control in patients with 21-hydroxylase deficiency","volume":"95","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref651","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1210\/jc.2007-0337","article-title":"Testicular tumors in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency show functional features of adrenocortical tissue","volume":"92","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref611","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1210\/jc.2009-1929","article-title":"Total adrenal volume but not testicular adrenal rest tumor volume is associated with hormonal control in patients with 21-hydroxylase deficiency","volume":"95","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref591","first-page":"645","article-title":"Asymptomatic testicular adrenal rest tumours in adolescent and adult males with congenital adrenal hyperplasia: basal and follow-up investigation after 2.6 years","volume":"17","year":"2004","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"155","DOI":"10.6065\/apem.2015.20.3.155","article-title":"Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia","volume":"20","year":"2015","journal-title":"Ann Pediatr Endocrinol Metab"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-2605.2009.00967.x","article-title":"Testicular adrenal rest tumours in boys, adolescents and adult men with congenital adrenal hyperplasia may be associated with the CYP21A2 mutation","volume":"33","year":"2010","journal-title":"Int J Androl"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/cen.12033","article-title":"Prevalence and long-term follow-up outcomes of testicular adrenal rest tumours in children and adolescent males with congenital adrenal hyperplasia","volume":"78","year":"2013","journal-title":"Clin Endocrinol"},{"key":"ref501","first-page":"1784","volume-title":"Caffey\u2019s pediatric diagnostic imaging","year":"2013"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1210\/jc.2018-01865","article-title":"Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an endocrine society clinical practice guideline","volume":"103","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.juro.2016.09.072","article-title":"Testicular adrenal rest tumors in boys and young adults with congenital adrenal hyperplasia","volume":"197","year":"2017","journal-title":"J Urol"},{"key":"ref691","first-page":"677","article-title":"Fertility in patients with congenital adrenal hyperplasia","volume":"19","year":"2006","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1210\/jcem.86.12.8090","article-title":"High prevalence of testicular adrenal rest tumors, impaired spermatogenesis, and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia","volume":"86","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1530\/EJE-11-0828","article-title":"Fertility, sexuality and testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia","volume":"166","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1507\/endocrj.K11E-034","article-title":"The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency","volume":"58","year":"2011","journal-title":"Endocr J"},{"key":"ref721","first-page":"705.e5","article-title":"Repeated successful induction of fertility after replacing hydrocortisone with dexamethasone in a patient with congenital adrenal hyperplasia and testicular adrenal rest tumors","volume":"8","year":"2007","journal-title":"Fertil Steril"},{"key":"ref291","first-page":"677","article-title":"Fertility in patients with congenital adrenal hyperplasia","volume":"19","year":"2006","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref31","first-page":"245","article-title":"Congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"21","year":"2000","journal-title":"Endocr Rev"},{"key":"ref191","first-page":"645","article-title":"Asymptomatic testicular adrenal rest tumours in adolescent and adult males with congenital adrenal hyperplasia: basal and follow-up investigation after 2.6 years","volume":"17","year":"2004","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref631","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1507\/endocrj.K11E-034","article-title":"The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency","volume":"58","year":"2011","journal-title":"Endocr J"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/adc.45.239.13","article-title":"Variations in the pattern of pubertal changes in boys","volume":"45","year":"1970","journal-title":"Arch Dis Child"},{"key":"ref621","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1530\/EC-17-0215","article-title":"GATA transcription factors in testicular adrenal rest tumours","volume":"6","year":"2017","journal-title":"Endocr Connect"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1210\/jc.2007-0337","article-title":"Testicular tumors in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency show functional features of adrenocortical tissue","volume":"92","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"E1820","DOI":"10.1210\/jc.2012-3181","article-title":"Testicular adrenal rest tumors develop independently of long-term disease control: a longitudinal analysis of 50 adult men with congenital adrenal hyperplasia due to classic 21-hydroxylase deficiency","volume":"98","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref101","first-page":"1784","volume-title":"Caffey\u2019s pediatric diagnostic imaging","year":"2013"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1046\/j.1365-2443.1996.00254.x","article-title":"Identical origin of adrenal cortex and gonad revealed by expression profiles of Ad4BP\/SF-1","volume":"1","year":"1996","journal-title":"Genes Cells"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1210\/jc.2018-01865","article-title":"Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an endocrine society clinical practice guideline","volume":"103","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1210\/jc.2007-0383","article-title":"Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal hyperplasia","volume":"92","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1530\/EJE-17-0862","article-title":"Gonadal function in adult male patients with congenital adrenal hyperplasia","volume":"178","year":"2018","journal-title":"Eur J Endocrinol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1530\/EJE-17-0862","article-title":"Gonadal function in adult male patients with congenital adrenal hyperplasia","volume":"178","year":"2018","journal-title":"Eur J Endocrinol"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/cen.13001","article-title":"Experience in optimizing fertility outcomes in men with congenital adrenal hyperplasia due to 21 hydroxylase deficiency","volume":"84","year":"2016","journal-title":"Clin Endocrinol"},{"key":"ref561","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1046\/j.1365-2443.1996.00254.x","article-title":"Identical origin of adrenal cortex and gonad revealed by expression profiles of Ad4BP\/SF-1","volume":"1","year":"1996","journal-title":"Genes Cells"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1590\/S0004-27302009000800022","article-title":"[Bilateral testicular tumors caused by congenital adrenal rest hyperplasia]","volume":"53","year":"2009","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"ref701","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1210\/jc.2007-0383","article-title":"Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal hyperplasia","volume":"92","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1530\/EJE-07-0201","article-title":"Prevalence of testicular adrenal rest tumours in male children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"157","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1590\/S0004-27302009000800022","article-title":"[Bilateral testicular tumors caused by congenital adrenal rest hyperplasia]","volume":"53","year":"2009","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-2605.2009.00967.x","article-title":"Testicular adrenal rest tumours in boys, adolescents and adult men with congenital adrenal hyperplasia may be associated with the CYP21A2 mutation","volume":"33","year":"2010","journal-title":"Int J Androl"},{"key":"ref731","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/cen.13001","article-title":"Experience in optimizing fertility outcomes in men with congenital adrenal hyperplasia due to 21 hydroxylase deficiency","volume":"84","year":"2016","journal-title":"Clin Endocrinol"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.compmedimag.2006.09.012","article-title":"Testicular adrenal rests in a patient with congenital adrenal hyperplasia: US and MRI features","volume":"30","year":"2006","journal-title":"Comput Med Imaging Graph"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1148\/radiology.198.1.8539414","article-title":"Testicular adrenal rest tissue in congenital adrenal hyperplasia: findings at Gray-scale and color Doppler US","volume":"198","year":"1996","journal-title":"Radiology"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"E1820","DOI":"10.1210\/jc.2012-3181","article-title":"Testicular adrenal rest tumors develop independently of long-term disease control: a longitudinal analysis of 50 adult men with congenital adrenal hyperplasia due to classic 21-hydroxylase deficiency","volume":"98","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1007\/s00330-002-1786-3","article-title":"Testicular adrenal rest tumours in postpubertal males with congenital adrenal hyperplasia: sonographic and MR features","volume":"13","year":"2003","journal-title":"Eur Radiol"},{"key":"ref601","doi-asserted-by":"crossref","first-page":"E524","DOI":"10.1210\/jc.2014-2036","article-title":"Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features","volume":"100","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref761","doi-asserted-by":"crossref","first-page":"155.e1","DOI":"10.1016\/j.jpurol.2017.11.011","article-title":"Testicular adrenal rest tumor screening and fertility counseling among males with congenital adrenal hyperplasia","volume":"14","year":"2018","journal-title":"J Pediatr Urol"},{"key":"ref431","first-page":"245","article-title":"Congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"21","year":"2000","journal-title":"Endocr Rev"},{"key":"ref261","first-page":"1","article-title":"Prevalence of testicular adrenal rest tumor and factors associated with its development in congenital adrenal hyperplasia","volume":"90","year":"2018","journal-title":"Horm Res Paediatr"},{"key":"ref341","first-page":"415","article-title":"Adrenal nodules in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency: regression after adequate hormonal control","volume":"14","year":"2001","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000316531","article-title":"Prevalence of testicular adrenal rest tissue in neonates","volume":"75","year":"2011","journal-title":"Horm Res Paediatr"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","year":"2009","journal-title":"Eur J Cancer"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000316531","article-title":"Prevalence of testicular adrenal rest tissue in neonates","volume":"75","year":"2011","journal-title":"Horm Res Paediatr"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"E524","DOI":"10.1210\/jc.2014-2036","article-title":"Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features","volume":"100","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref491","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1590\/S0004-27302013000200005","article-title":"Final height in congenital adrenal hyperplasia: the dilemma of hypercortisolism versus hyperandrogenism","volume":"57","year":"2013","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000365570","article-title":"Increased prevalence of testicular adrenal rest tumours during adolescence in congenital adrenal hyperplasia","volume":"82","year":"2014","journal-title":"Horm Res Paediatr"},{"key":"ref661","first-page":"1","article-title":"Prevalence of testicular adrenal rest tumor and factors associated with its development in congenital adrenal hyperplasia","volume":"90","year":"2018","journal-title":"Horm Res Paediatr"},{"key":"ref671","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1530\/EJE-07-0201","article-title":"Prevalence of testicular adrenal rest tumours in male children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"157","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"ref681","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/cen.12033","article-title":"Prevalence and long-term follow-up outcomes of testicular adrenal rest tumours in children and adolescent males with congenital adrenal hyperplasia","volume":"78","year":"2013","journal-title":"Clin Endocrinol"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"e1471","DOI":"10.1097\/MD.0000000000001471","article-title":"Diagnosis of testicular adrenal rest tumors on ultrasound: a retrospective study of 15 cases report","volume":"94","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"ref791","doi-asserted-by":"crossref","first-page":"155","DOI":"10.6065\/apem.2015.20.3.155","article-title":"Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia","volume":"20","year":"2015","journal-title":"Ann Pediatr Endocrinol Metab"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.beem.2008.09.007","article-title":"Testicular adrenal rest tumours in congenital adrenal hyperplasia","volume":"23","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref741","first-page":"415","article-title":"Adrenal nodules in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency: regression after adequate hormonal control","volume":"14","year":"2001","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000365570","article-title":"Increased prevalence of testicular adrenal rest tumours during adolescence in congenital adrenal hyperplasia","volume":"82","year":"2014","journal-title":"Horm Res Paediatr"},{"key":"ref711","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1530\/EJE-11-0828","article-title":"Fertility, sexuality and testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia","volume":"166","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"ref511","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","year":"2009","journal-title":"Eur J Cancer"},{"key":"ref771","doi-asserted-by":"crossref","first-page":"e1471","DOI":"10.1097\/MD.0000000000001471","article-title":"Diagnosis of testicular adrenal rest tumors on ultrasound: a retrospective study of 15 cases report","volume":"94","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.compmedimag.2006.09.012","article-title":"Testicular adrenal rests in a patient with congenital adrenal hyperplasia: US and MRI features","volume":"30","year":"2006","journal-title":"Comput Med Imaging Graph"},{"key":"ref551","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/00000478-198807000-00001","article-title":"The testicular \u201ctumor\u201d of the adrenogenital syndrome. A report of six cases and review of the literature on testicular masses in patients with adrenocortical disorders","volume":"12","year":"1988","journal-title":"Am J Surg Pathol"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1530\/EC-17-0215","article-title":"GATA transcription factors in testicular adrenal rest tumours","volume":"6","year":"2017","journal-title":"Endocr Connect"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1210\/jcem-23-9-861","article-title":"Activation of testicular adrenal rest tissue by prolonged excessive ACTH production","volume":"23","year":"1963","journal-title":"J Clin Endocrinol Metab"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/00000478-198807000-00001","article-title":"The testicular \u201ctumor\u201d of the adrenogenital syndrome. A report of six cases and review of the literature on testicular masses in patients with adrenocortical disorders","volume":"12","year":"1988","journal-title":"Am J Surg Pathol"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1210\/jc.2008-1414","article-title":"High prevalence of reduced fecundity in men with congenital adrenal hyperplasia","volume":"94","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.beem.2008.09.007","article-title":"Testicular adrenal rest tumours in congenital adrenal hyperplasia","volume":"23","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref321","first-page":"705.e5","article-title":"Repeated successful induction of fertility after replacing hydrocortisone with dexamethasone in a patient with congenital adrenal hyperplasia and testicular adrenal rest tumors","volume":"8","year":"2007","journal-title":"Fertil Steril"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/adc.45.239.13","article-title":"Variations in the pattern of pubertal changes in boys","volume":"45","year":"1970","journal-title":"Arch Dis Child"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jpem.2019.32.issue-5\/jpem-2018-0512\/jpem-2018-0512.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2018-0512\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T21:58:57Z","timestamp":1721253537000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2018-0512\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,27]]},"references-count":80,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1515\/jpem-2018-0512","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5,27]]}}}