{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T10:23:59Z","timestamp":1744626239948},"reference-count":60,"publisher":"Walter de Gruyter GmbH","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"j_jpem-2018-0546_s_999\">\n<jats:title id=\"d614445e15441\">Background<\/jats:title>\n<jats:p>Fibroblast growth factor 21 (FGF21) is considered an important regulator of lipid and glucose metabolism. However, the role of FGF21 in macronutrient intake and metabolic disease, particularly in pediatric population, still needs further clarification. This study aimed to evaluate the association of rs11665896 in the <jats:italic>FGF21<\/jats:italic> gene with metabolic status and macronutrient intake in a cohort of Mexican children with obesity.<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_jpem-2018-0546_s_998\">\n<jats:title id=\"d614445e15452\">Methods<\/jats:title>\n<jats:p>Eighty-four lean children and 113 children with obesity, from 8 to 11 years of age, were recruited. <jats:italic>FGF21<\/jats:italic> rs11665896 was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Somatometric evaluations, nutrient intake, glucose, lipids, insulin and FGF21 serum levels were measured in the obesity group.<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_jpem-2018-0546_s_997\">\n<jats:title id=\"d614445e15463\">Results<\/jats:title>\n<jats:p>The T allele of rs11665896 in the <jats:italic>FGF21<\/jats:italic> gene was associated with obesity (odds ratio [OR]\u2009=\u20091.99, 95% confidence interval [CI]\u2009=\u20091.14\u20133.46; p\u2009=\u20090.0151). Subjects with obesity carrying the TT genotype consumed less lipids and more carbohydrates compared to other genotypes. Circulating FGF21 levels correlated negatively with carbohydrate intake (r\u2009=\u2009\u22120.232, p\u2009=\u20090.022) and positively with body weight (r\u2009=\u20090.269, p\u2009=\u20090.007), waist (r\u2009=\u20090.242, p\u2009=\u20090.016) and hip girth (r\u2009=\u20090.204, p\u2009=\u20090.042). FGF21 levels were lower in carriers of at least one T allele.<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_jpem-2018-0546_s_996\">\n<jats:title id=\"d614445e15474\">Conclusions<\/jats:title>\n<jats:p>Genetic variants in <jats:italic>FGF21<\/jats:italic> could influence metabolic status, food preferences and qualitative changes in nutritional behavior in children.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2018-0546","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T09:04:00Z","timestamp":1563527040000},"page":"921-928","source":"Crossref","is-referenced-by-count":6,"title":["Association of the 3\u2032UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity"],"prefix":"10.1515","volume":"32","author":[{"given":"Alan Joel","family":"Ruiz-Padilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Morales-Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeniley","family":"Ruiz-Noa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel Josabad","family":"Alonso-Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Lazo-de-la-Vega-Monroy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica del Carmen","family":"Preciado-Puga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Rangel-Salazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena del Rocio","family":"Ibarra-Reynoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref341","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1053\/j.gastro.2014.07.044","article-title":"Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets","volume":"147","year":"2014","journal-title":"Gastroenterology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.2337\/db10-0193","article-title":"Obesity is a fibroblast growth factor 21 (FGF21)-resistant state","volume":"59","year":"2010","journal-title":"Diabetes"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.celrep.2018.03.070","article-title":"A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure","volume":"23","year":"2018","journal-title":"Cell Rep"},{"key":"ref501","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1136\/bmj.320.7244.1240","article-title":"Establishing a standard definition for child overweight and obesity worldwide: international survey","volume":"320","year":"2000","journal-title":"Br Med J"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1038\/ijo.2008.127","article-title":"Genetic influence on appetite in children","volume":"32","year":"2008","journal-title":"Int J Obes (Lond)"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1079\/BJN19710102","article-title":"Composition of human adipose tissue from deep and subcutaneous sites","volume":"25","year":"1971","journal-title":"Br J Nutr"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1053\/j.gastro.2014.07.044","article-title":"Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid 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