{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:06:48Z","timestamp":1781647608246,"version":"3.54.5"},"reference-count":9,"publisher":"Walter de Gruyter GmbH","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,26]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n PHACE syndrome is a rare vascular neurocutaneous disorder characterized by posterior fossa anomalies, hemangioma, arterial anomalies, cardiac anomalies and eye anomalies. Growth hormone deficiency (GHD) has been infrequently described.<\/jats:p>\n <\/jats:sec>\n \n Case presentation<\/jats:title>\n We report a girl with PHACE syndrome. Endocrine abnormalities including abnormal thyroid functions and GHD have recently been described in similar cases.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This case suggests the necessity to screen pituitary functions in all patients with PHACE syndrome with abnormal hypothalamus and pituitary (HP) anatomy. Likewise, growth parameters and thyroid function test (TFT) should be monitored in all patients with PHACE syndrome at regular intervals.<\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/jpem-2019-0078","type":"journal-article","created":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T09:54:31Z","timestamp":1567331671000},"page":"1283-1286","source":"Crossref","is-referenced-by-count":2,"title":["A case of PHACE syndrome with growth hormone deficiency and abnormal thyroid functions"],"prefix":"10.1515","volume":"32","author":[{"given":"Chansuda","family":"Bongsebandhu-phubhakdi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital , 1873 Rama 4 Rd., Pathumwan , Bangkok 10330 , Thailand , Phone: +66 2 2564951, Fax: +66 89 1574651, E-mail:"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therdpong","family":"Tempark","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine , Chulalongkorn University and King Chulalongkorn Memorial Hospital , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketsuda","family":"Jakchairoongruang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vichit","family":"Supornsilpchai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine , Chulalongkorn University and King Chulalongkorn Memorial Hospital , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,9,2]]},"reference":[{"key":"2023040101012431325_j_jpem-2019-0078_ref_001_w2aab3b7b6b1b6b1ab1b6b1Aa","doi-asserted-by":"crossref","unstructured":"Frieden IJ, Reese V, Cohen D. PHACE syndrome. The association of posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities. Arch Dermatol 1996;132:307\u201311.10.1001\/archderm.1996.038902700830128607636","DOI":"10.1001\/archderm.132.3.307"},{"key":"2023040101012431325_j_jpem-2019-0078_ref_002_w2aab3b7b6b1b6b1ab1b6b2Aa","doi-asserted-by":"crossref","unstructured":"Garzon MC, Epstein LG, Heyer GL, Frommelt PC, Orbach DB, et al. PHACE syndrome: consensus-derived diagnosis and care recommendations. J Pediatr 2016;178:24\u201333.e2.10.1016\/j.jpeds.2016.07.05427659028","DOI":"10.1016\/j.jpeds.2016.07.054"},{"key":"2023040101012431325_j_jpem-2019-0078_ref_003_w2aab3b7b6b1b6b1ab1b6b3Aa","doi-asserted-by":"crossref","unstructured":"Blei F, McElhinney DB, Guarini A, Presti S. Cardiac screening in infants with infantile hemangiomas before propranolol treatment. Pediatr Dermatol 2014;31:465\u201370.10.1111\/pde.1234424889812","DOI":"10.1111\/pde.12344"},{"key":"2023040101012431325_j_jpem-2019-0078_ref_004_w2aab3b7b6b1b6b1ab1b6b4Aa","doi-asserted-by":"crossref","unstructured":"Haggstrom AN, Lammer EJ, Schneider RA, Marcucio R, Frieden IJ. Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development. Pediatrics 2006;117:698\u2013703.10.1542\/peds.2005-109216510649","DOI":"10.1542\/peds.2005-1092"},{"key":"2023040101012431325_j_jpem-2019-0078_ref_005_w2aab3b7b6b1b6b1ab1b6b5Aa","doi-asserted-by":"crossref","unstructured":"Bongsebandhu-phubhakdi C, Tempark T, Supornsilpchai V. Endocrine manifestations of PHACE syndrome. 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