{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:39:58Z","timestamp":1756384798384},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2019-0082_s_999_w2aab3b7b7b1b6b1aab1c19b1Aa\">\n                  <jats:title id=\"d1057614e17982_w2aab3b7b7b1b6b1aab1c19b1aAa\">Background<\/jats:title>\n                  <jats:p>Acquired von Willebrand\u2019s syndrome (aVWS) associated with hypothyroidism is rare in children and more often diagnosed during the peripubertal period in the context of Hashimoto\u2019s thyroiditis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0082_s_998_w2aab3b7b7b1b6b1aab1c19b2Aa\">\n                  <jats:title id=\"d1057614e17990_w2aab3b7b7b1b6b1aab1c19b2aAa\">Case presentation<\/jats:title>\n                  <jats:p>A 5-year-old girl was referred to the paediatric haematology unit for rectal bleeding, anaemia and prolonged activated partial thromboplastin time (aPTT). Her developmental and learning skills were normal. The physical examination revealed severe short stature (height SDS: \u22123.6) with overweight (body mass index SDS: 1.8) and clinical sign of hypothyroidism. Laboratory investigation revealed aVWS type 1 associated with severe primary hypothyroidism. Anti-thyroid antibodies were negative and thyroid ultrasound found thyroid hypoplasia in favour of congenital hypothyroidism. Restoration of euthyroidism was associated with increased growth velocity and normalisation of coagulation parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0082_s_997_w2aab3b7b7b1b6b1aab1c19b3Aa\">\n                  <jats:title id=\"d1057614e17998_w2aab3b7b7b1b6b1aab1c19b3aAa\">Conclusion<\/jats:title>\n                  <jats:p>This report highlights the importance of excluding an underlying pathology (including hypothyroidism) in children with suspected VWS, even in young age.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2019-0082","type":"journal-article","created":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T16:19:46Z","timestamp":1567268386000},"page":"1295-1298","source":"Crossref","is-referenced-by-count":4,"title":["Acquired von Willebrand\u2019s syndrome caused by primary hypothyroidism in a 5-year-old girl"],"prefix":"10.1515","volume":"32","author":[{"given":"Claire","family":"Flot","sequence":"first","affiliation":[{"name":"Paediatric Endocrine Unit, Children\u2019s Hospital , Purpan University Hospital , Toulouse , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Oliver","sequence":"additional","affiliation":[{"name":"Paediatric Endocrine Unit, Children\u2019s Hospital , Purpan University Hospital , Toulouse , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Caron","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases , Larrey University Hospital , Toulouse , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Savagner","sequence":"additional","affiliation":[{"name":"Biochemistry and Genetic Laboratory, Federative Institute of Biology , Purpan University Hospital , Toulouse , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maith\u00e9","family":"Tauber","sequence":"additional","affiliation":[{"name":"Paediatric Endocrine Unit, Children\u2019s Hospital , Purpan University Hospital , Toulouse , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9gol\u00e8ne","family":"Claeyssens","sequence":"additional","affiliation":[{"name":"Haemophilia Care Center, Medical Department , Purpan University Hospital , Toulouse , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Edouard","sequence":"additional","affiliation":[{"name":"Paediatric Endocrine Unit, Children\u2019s Hospital , Purpan University Hospital , Toulouse , France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,8,31]]},"reference":[{"key":"2023040101012437818_j_jpem-2019-0082_ref_001_w2aab3b7b7b1b6b1ab1b5b1Aa","doi-asserted-by":"crossref","unstructured":"Federici AB, Budde U, Castaman G, Rand JH, Tiede A. 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