{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T17:22:19Z","timestamp":1768929739764,"version":"3.49.0"},"reference-count":42,"publisher":"Walter de Gruyter GmbH","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2019-0105_s_999_w2aab3b7b6b1b6b1aab1c18b1Aa\">\n                  <jats:title id=\"d2761551e19631_w2aab3b7b6b1b6b1aab1c18b1aAa\">Background<\/jats:title>\n                  <jats:p>The use of gonadotropin-releasing hormone agonists (GnRHa) for pubertal suppression has been associated with increased body mass index (BMI) in female subjects with central precocious puberty (CPP), although results have been so far conflicting. This study examined the effects of GnRHa therapy in both genders and in subjects treated for CPP, early puberty or short stature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0105_s_998_w2aab3b7b6b1b6b1aab1c18b2Aa\">\n                  <jats:title id=\"d2761551e19639_w2aab3b7b6b1b6b1aab1c18b2aAa\">Methods<\/jats:title>\n                  <jats:p>This was a longitudinal retrospective study of subjects followed at outpatient pediatric endocrinology clinics of an academic medical center from 2005 to 2014 receiving GnRHa therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0105_s_997_w2aab3b7b6b1b6b1aab1c18b3Aa\">\n                  <jats:title id=\"d2761551e19647_w2aab3b7b6b1b6b1aab1c18b3aAa\">Results<\/jats:title>\n                  <jats:p>At 12 months, subjects on depot GnRHa had a statistically significant increase in BMI standard deviation score (SDS) from baseline (0.13\u2009\u00b1\u20090.35, p\u2009&lt;\u20090.02). Subjects with short stature (0.17\u2009\u00b1\u20090.34, p\u2009&lt;\u20090.02) but not early or precocious puberty, and subjects with normal baseline BMI (0.18\u2009\u00b1\u20090.38, p\u2009&lt;\u20090.02) had significant increases in BMI SDS; no significance was noted at 24 months. Male subjects did not have a significant increase in BMI SDS, whereas female subjects did (0.11\u2009\u00b1\u20090.36, p\u2009&lt;\u20090.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0105_s_996_w2aab3b7b6b1b6b1aab1c18b4Aa\">\n                  <jats:title id=\"d2761551e19655_w2aab3b7b6b1b6b1aab1c18b4aAa\">Conclusions<\/jats:title>\n                  <jats:p>Subjects with short stature, normal BMI at baseline and female sex had significant increases in BMI SDS at 12 months. This is the first study to show an increase in BMI SDS in children treated with GnRHa for short stature, and is one of the few studies to assess BMI changes in males.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2019-0105","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T09:04:16Z","timestamp":1567069456000},"page":"1065-1070","source":"Crossref","is-referenced-by-count":18,"title":["Changes in body mass index in children on gonadotropin-releasing hormone agonist therapy with precocious puberty, early puberty or short stature"],"prefix":"10.1515","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0247-3237","authenticated-orcid":false,"given":"Marisa","family":"Censani","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine, New York Presbyterian Hospital , Division of Pediatric Endocrinology, Department of Pediatrics , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Feuer","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, New York Presbyterian Hospital , Division of Pediatric Endocrinology, Department of Pediatrics , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Orton","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, New York Presbyterian Hospital , Division of Pediatric Endocrinology, Department of Pediatrics , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulce","family":"Askin","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine , Division of Biostatistics and Epidemiology, Department of Healthcare Policy and Research , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Vogiatzi","sequence":"additional","affiliation":[{"name":"The Children\u2019s Hospital of Philadelphia , Division of Pediatric Endocrinology and Diabetes , Philadelphia, PA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,8,29]]},"reference":[{"key":"2023040101010091645_j_jpem-2019-0105_ref_001_w2aab3b7b6b1b6b1ab1b6b1Aa","doi-asserted-by":"crossref","unstructured":"Lahlou N, Carel JC, Chaussain JL, Roger M. 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