{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:34:59Z","timestamp":1785454499287,"version":"3.56.0"},"reference-count":80,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"j_jpem-2019-0136_s_999\">\n<jats:title id=\"d1913515e14746\">Background<\/jats:title>\n<jats:p>The standard treatment of central precocious puberty (CPP) is gonadotropin-releasing hormone analogues (GnRHa). It is a concern that children treated with GnRHa are at risk of developing obesity which could impair the treatment outcomes. This study aimed to investigate the effect of GnRHa on body mass index (BMI) standard deviation score (SDS), and the influence of BMI status on treatment outcomes in children with idiopathic CPP (iCPP).<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_jpem-2019-0136_s_998\">\n<jats:title id=\"d1913515e14754\">Methods<\/jats:title>\n<jats:p>A retrospective cohort study in children with iCPP who completed GnRHa treatment and had attained near final adult height (NFAH) was conducted. Children with a history of disease or drug ingestion which could affect their BMI were excluded. BMI, BMI SDS, height (Ht), Ht SDS, predicted adult height (PAH), and NFAH were compared at baseline, 1 and 2 years during treatment, and at NFAH according to the baseline BMI status; normal weight and overweight\/obesity.<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_jpem-2019-0136_s_997\">\n<jats:title id=\"d1913515e14762\">Results<\/jats:title>\n<jats:p>Fifty-eight children with iCPP treated with GnRHa were enrolled. The BMI SDS was significantly increased at 1 and 2 years during treatment in the overweight\/obese group and at 1 year during treatment in the normal-weight group. However, at NFAH (2 years after treatment discontinuation), the BMI SDS was not statistically different from baseline in both groups. Ht gain, change in Ht SDS and BMI SDS were not statistically different from the baseline in both groups.<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_jpem-2019-0136_s_996\">\n<jats:title id=\"d1913515e14770\">Conclusions<\/jats:title>\n<jats:p>GnRHa results in a transient increase in BMI SDS during treatment and returned to baseline after treatment cessation. The benefit of GnRHa treatment on final Ht improvement is similar between overweight\/obese and normal-weight patients.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2019-0136","type":"journal-article","created":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T10:55:14Z","timestamp":1570877714000},"page":"1369-1375","source":"Crossref","is-referenced-by-count":15,"title":["Near final adult height, and body mass index in overweight\/obese and normal-weight children with idiopathic central precocious puberty and treated with gonadotropin-releasing hormone analogs"],"prefix":"10.1515","volume":"32","author":[{"given":"Pattharaphorn","family":"Sinthuprasith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prapai","family":"Dejkhamron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karn","family":"Wejaphikul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevalee","family":"Unachak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref491","first-page":"4583","article-title":"Long-term outcome after depot gonadotropin-releasing hormone agonist treatment of central precocious puberty: final height, body proportions, body composition, bone mineral density, and reproductive function","volume":"84","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"267","DOI":"10.4103\/2230-8210.131770","article-title":"Effect of gonadotropin-releasing hormone agonist therapy on body mass index and growth in girls with idiopathic central precocious puberty","volume":"19","year":"2015","journal-title":"Indian J Endocrinol Metab"},{"key":"ref361","volume-title":"Changes in body mass index during gonadotropin-releasing hormone agonist treatment for central precocious puberty and early puberty","year":"2016"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1210\/jc.2013-1024","article-title":"Treatment and outcomes of precocious puberty: an update","volume":"98","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref791","doi-asserted-by":"crossref","first-page":"259","DOI":"10.6065\/apem.2017.22.4.259","article-title":"Treatment outcomes of gonadotropin-releasing hormone agonist in obese girls with central precocious puberty","volume":"22","year":"2017","journal-title":"Ann Pediatr Endocrinol Metab"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000320039","article-title":"Changes in bone mineral density and body composition in children with central precocious puberty and early puberty before and after one year of treatment with GnRH agonist","volume":"75","year":"2011","journal-title":"Horm Res Paediatr"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jadohealth.2011.10.254","article-title":"Is obesity at individual and national level associated with lower age at menarche? 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