{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:50:14Z","timestamp":1747198214402,"version":"3.40.5"},"reference-count":10,"publisher":"Walter de Gruyter GmbH","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,25]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Pheochromocytomas (PCCs) and paragangliomas (PGLs) are known to physicians as the \u201cgreat mimickers\u201d because of their variable presentation, especially in the pediatric population. Rarely, they co-secrete other hormones.<\/jats:p>\n <\/jats:sec>\n \n Case presentation<\/jats:title>\n An 11-year-old boy presented with severe hypertension (HTN) with cardiac target organ damage. Signs of genital and cutaneous androgenization were observed, but the gonadal volume was prepubertal (2 mL). Urine normetanephrine and norepinephrine levels were elevated. Increased beta-human chorionic gonadotropin (\u03b2-HCG) and pubertal testosterone values with suppressed values of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) suggested an androgenization secondary to HCG hyperproduction. Imaging revealed a right adrenal mass, suggestive for PCC. Histopathology confirmed a PCC with positive staining for \u03b2-HCG. Postoperative resolution of symptoms of \u03b2-HCG and catecholamine excess and normalization of hormonal levels confirmed the diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Ectopic hormone secretion from PCC is possible, even if rare. Signs and symptoms attributable to ectopic hormones should be investigated in PCC patients. To date, this is the first case of a \u03b2-HCG-secreting PCC.<\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/jpem-2019-0216","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T09:04:04Z","timestamp":1567760644000},"page":"1193-1197","source":"Crossref","is-referenced-by-count":0,"title":["Severe arterial hypertension and hyperandrogenism in a boy: a rare case of catecholamine- and \u03b2-HCG-secreting pheochromocytoma"],"prefix":"10.1515","volume":"32","author":[{"given":"Federica","family":"Chiale","sequence":"first","affiliation":[{"name":"Regina Margherita Children\u2019s Hospital , Postgraduation School of Pediatrics, AOU Citt\u00e0 della Salute e della Scienza, University of Turin , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4334-9822","authenticated-orcid":false,"given":"Enrica","family":"Abrigo","sequence":"additional","affiliation":[{"name":"Regina Margherita Children\u2019s Hospital , Postgraduation School of Pediatrics, AOU Citt\u00e0 della Salute e della Scienza, University of Turin , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Lonati","sequence":"additional","affiliation":[{"name":"Regina Margherita Children\u2019s Hospital , Division of Pediatric General Surgery, AOU Citt\u00e0 della Salute e della Scienza, University of Turin , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpaolo","family":"Di Rosa","sequence":"additional","affiliation":[{"name":"Regina Margherita Children\u2019s Hospital , Department of Radiology, AOU Citt\u00e0 della Salute e della Scienza, University of Turin , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Morra","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero Universitaria Citt\u00e0 della Salute e della Scienza di Torino , Department of Pathology , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Licia","family":"Peruzzi","sequence":"additional","affiliation":[{"name":"Regina Margherita Children\u2019s Hospital , Nephrology Dialysis and Transplantation Unit, AOU Citt\u00e0 della Salute e della Scienza, University of Turin , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Einaudi","sequence":"additional","affiliation":[{"name":"Regina Margherita Children\u2019s Hospital , Pediatric Endocrinology, AOU Citta della Salute e della Scienza, University of Turin , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,9,6]]},"reference":[{"key":"2023040101010086974_j_jpem-2019-0216_ref_001_w2aab3b7c14b1b6b1ab1b6b1Aa","doi-asserted-by":"crossref","unstructured":"Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, et al. 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