{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:02:58Z","timestamp":1757455378474,"version":"3.37.3"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"j_jpem-2019-0222_s_999\">\n<jats:title id=\"d614445e45203\">Background<\/jats:title>\n<jats:p>Stroke and other neurologic complications are rare in pediatric type 1 diabetes mellitus (T1DM) without severe diabetic ketoacidosis (DKA) or poor glycemic control.<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_jpem-2019-0222_s_998\">\n<jats:title id=\"d614445e45211\">Case presentation<\/jats:title>\n<jats:p>A previously healthy, 10-year-old female presented with acute thalamic stroke, non-acidotic new T1DM diagnosis and negative hypercoagulopathy workup. She received routine insulin therapy and aspirin, and returned to neurologic baseline within a year without stroke recurrence.<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_jpem-2019-0222_s_997\">\n<jats:title id=\"d614445e45219\">Conclusions<\/jats:title>\n<jats:p>The contribution of non-acidotic hyperglycemia to stroke risk is better described in adults. Even though unable to prove causality, this case should at least raise awareness of the possible association of pediatric new-onset diabetes and stroke for optimal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2019-0222","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T09:04:00Z","timestamp":1563527040000},"page":"1035-1037","source":"Crossref","is-referenced-by-count":2,"title":["Pediatric stroke as the presenting symptom of new-onset type 1 diabetes mellitus without DKA: case report and literature review"],"prefix":"10.1515","volume":"32","author":[{"given":"Sonum A.","family":"Bharill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janel D.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth T.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F.","family":"Crudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8363-257X","authenticated-orcid":false,"given":"Cathrine","family":"Constantacos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref221","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1081\/ERC-120018678","article-title":"Diabetic ketoacidosis promotes a prothrombotic state","volume":"29","year":"2003","journal-title":"Endocr Res"},{"key":"ref41","first-page":"219706","article-title":"Diabetic ketoacidosis-associated stroke in children and youth","volume":"2011","year":"2011","journal-title":"Stroke Res Treat"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1136\/bmj.1.4140.766","article-title":"Renal threshold for glucose: normal and in diabetics","volume":"1","year":"1940","journal-title":"Br Med J"},{"key":"ref31","first-page":"749","article-title":"Atypical neurologic presentations of new onset type 1 diabetes mellitus in pediatric age group: a report of five unusual cases and review of the literature","volume":"27","year":"2014","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.braindev.2007.06.001","article-title":"Occult infarct with acute hemorrhagic stroke in juvenile diabetic ketoacidosis","volume":"30","year":"2008","journal-title":"Brain Dev"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.09.019","article-title":"Metabolic Syndrome and the risk of ischemic stroke","volume":"26","year":"2017","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"ref231","first-page":"100","article-title":"Hyperglycemia and diabetes have different impacts on outcome of ischemic and hemorrhagic stroke","volume":"13","year":"2017","journal-title":"Arch Med Sci"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1399-543X.2006.00151.x","article-title":"Pediatric stroke associated with new onset type 1 diabetes mellitus: case reports and review of the literature","volume":"7","year":"2006","journal-title":"Pediatr Diabetes"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e938","DOI":"10.1542\/peds.2013-2795","article-title":"Trends in the prevalence of ketoacidosis at diabetes diagnosis: the SEARCH for Diabetes in Youth Study","volume":"133","year":"2014","journal-title":"Pediatrics"},{"key":"ref181","first-page":"219706","article-title":"Diabetic ketoacidosis-associated stroke in children and youth","volume":"2011","year":"2011","journal-title":"Stroke Res Treat"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2147\/NDT.S128807","article-title":"Role of prediabetes in stroke","volume":"13","year":"2017","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1399-543X.2006.00151.x","article-title":"Pediatric stroke associated with new onset type 1 diabetes mellitus: case reports and review of the literature","volume":"7","year":"2006","journal-title":"Pediatr Diabetes"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1161\/hs1001.096194","article-title":"Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview","volume":"32","year":"2001","journal-title":"Stroke"},{"key":"ref91","first-page":"100","article-title":"Hyperglycemia and diabetes have different impacts on outcome of ischemic and hemorrhagic stroke","volume":"13","year":"2017","journal-title":"Arch Med Sci"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.vph.2009.02.004","article-title":"Hyperglycemia, diabetes and stroke: focus on the cerebrovasculature","volume":"51","year":"2009","journal-title":"Vascul Pharmacol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.braindev.2007.06.001","article-title":"Occult infarct with acute hemorrhagic stroke in juvenile diabetic ketoacidosis","volume":"30","year":"2008","journal-title":"Brain Dev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/dme.12048","article-title":"The broad clinical phenotype of type 1 diabetes at presentation","volume":"30","year":"2013","journal-title":"Diabet Med"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1161\/hs1001.096194","article-title":"Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview","volume":"32","year":"2001","journal-title":"Stroke"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.vph.2009.02.004","article-title":"Hyperglycemia, diabetes and stroke: focus on the cerebrovasculature","volume":"51","year":"2009","journal-title":"Vascul Pharmacol"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1136\/bmj.1.4140.766","article-title":"Renal threshold for glucose: normal and in diabetics","volume":"1","year":"1940","journal-title":"Br Med J"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1081\/ERC-120018678","article-title":"Diabetic ketoacidosis promotes a prothrombotic state","volume":"29","year":"2003","journal-title":"Endocr Res"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1542\/peds.2006-0690","article-title":"The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study","volume":"118","year":"2006","journal-title":"Pediatrics"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1542\/peds.2006-0690","article-title":"The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study","volume":"118","year":"2006","journal-title":"Pediatrics"},{"key":"ref171","first-page":"749","article-title":"Atypical neurologic presentations of new onset type 1 diabetes mellitus in pediatric age group: a report of five unusual cases and review of the literature","volume":"27","year":"2014","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.09.019","article-title":"Metabolic Syndrome and the risk of ischemic stroke","volume":"26","year":"2017","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/dme.12048","article-title":"The broad clinical phenotype of type 1 diabetes at presentation","volume":"30","year":"2013","journal-title":"Diabet Med"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"e938","DOI":"10.1542\/peds.2013-2795","article-title":"Trends in the prevalence of ketoacidosis at diabetes diagnosis: the SEARCH for Diabetes in Youth Study","volume":"133","year":"2014","journal-title":"Pediatrics"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2147\/NDT.S128807","article-title":"Role of prediabetes in stroke","volume":"13","year":"2017","journal-title":"Neuropsychiatr Dis Treat"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jpem.2019.32.issue-9\/jpem-2019-0222\/jpem-2019-0222.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2019-0222\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T01:46:06Z","timestamp":1619055966000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2019-0222\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,25]]},"references-count":28,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.1515\/jpem-2019-0222","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"type":"electronic","value":"2191-0251"},{"type":"print","value":"0334-018X"}],"subject":[],"published":{"date-parts":[[2019,9,25]]}}}