{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:39:01Z","timestamp":1792521541916,"version":"4.5.0"},"reference-count":44,"publisher":"Walter de Gruyter GmbH","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2019-0226_s_999_w2aab3b7c15b1b6b1aab1c17b1Aa\">\n                  <jats:title id=\"d2761551e52133_w2aab3b7c15b1b6b1aab1c17b1aAa\">Background<\/jats:title>\n                  <jats:p>Recent emerging evidence supports the role of miR-196a2 in various human diseases. However, its role in type 1 diabetes mellitus (T1DM) is still underestimated. We aimed, for the first time, to investigate the expression of miR-196a2 in T1DM and the association of <jats:italic>miR-196a2<\/jats:italic> (rs11614913) polymorphism with susceptibility of T1DM in a sample of patients from Cairo, Egypt.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0226_s_998_w2aab3b7c15b1b6b1aab1c17b2Aa\">\n                  <jats:title id=\"d2761551e52144_w2aab3b7c15b1b6b1aab1c17b2aAa\">Methods<\/jats:title>\n                  <jats:p>The study included 150 patients and 150 healthy subjects. Evaluation of rs11614913 genotypes and miR-196a2 expression was done using the allelic discrimination and quantitative reverse transcriptase polymerase chain reaction (PCR) method, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0226_s_997_w2aab3b7c15b1b6b1aab1c17b3Aa\">\n                  <jats:title id=\"d2761551e52152_w2aab3b7c15b1b6b1aab1c17b3aAa\">Results<\/jats:title>\n                  <jats:p>The Hardy-Weinberg equilibrium of single nucleotide polymorphism(SNP) was detected among controls (p\u2009=\u20090.2). Our results revealed that the TT genotype was more frequent in patients (22.6%) than controls (10%) while the CC genotype was more frequent in controls (47.3%) than patients (39.3%) (p\u2009=\u20090.01). The frequency of the T allele was significantly higher in patients than in controls (41.7 vs. 31.3%), while the C allele was more frequent in controls (p\u2009=\u20090.008). After adjustment for traditional risk factors, the association of the TT genotype with T1DM remained significant (TT vs. CC, odds ration [OR]\u2009=\u20093.2, 95% confidence interval [CI]: 1.4\u20137.4, p\u2009=\u20090.005). Power analysis of the data yielded a statistical power of 80% for the miR-196a2 rs11614913 with T1DM. Relative expression of miR-196a2 showed significant decrease in patients compared to controls (median\u2009=\u20090.09, 0.5, interquartile range [IQR]\u2009=\u20090.03\u20131.6, 0.1\u20132.1). However, miR-196a2 expression showed no significant difference between different rs11614913 genotypes (p\u2009=\u20090.5).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0226_s_996_w2aab3b7c15b1b6b1aab1c17b4Aa\">\n                  <jats:title id=\"d2761551e52160_w2aab3b7c15b1b6b1aab1c17b4aAa\">Conclusions<\/jats:title>\n                  <jats:p>Our findings demonstrated that miR-196a rs11614913 is associated with T1DM and decreased expression of miR-196a2 may play a role in pathogenesis of T1DM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2019-0226","type":"journal-article","created":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T16:19:46Z","timestamp":1567268386000},"page":"1171-1179","source":"Crossref","is-referenced-by-count":11,"title":["Micro-RNA 196a2 expression and miR-196a2 (rs11614913) polymorphism in T1DM: a pilot study"],"prefix":"10.1515","volume":"32","author":[{"given":"Alshaymaa A.","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Clinical and Chemical Pathology Department , National Research Centre , El Buhouth St, Dokki , Cairo 12311 , Egypt , Phone: 00201006193988, Fax: +20233370931"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer","family":"Ramadan","sequence":"additional","affiliation":[{"name":"Molecular Genetics and Enzymology Department , Human Genetic and Genome Research Division, National Research Centre , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliaa Ahmed","family":"Wahby","sequence":"additional","affiliation":[{"name":"Clinical and Chemical Pathology Department , National Research Centre , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirhane","family":"Hassan","sequence":"additional","affiliation":[{"name":"Clinical and Chemical Pathology Department , National Research Centre , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hend M.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Pediatric Department , Cairo University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer A.","family":"Abdel Hamid","sequence":"additional","affiliation":[{"name":"Pediatric Department , Cairo University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,8,31]]},"reference":[{"key":"2023040101010094353_j_jpem-2019-0226_ref_001_w2aab3b7c15b1b6b1ab1b6b1Aa","doi-asserted-by":"crossref","unstructured":"Yang CC, Lin CH, Wang NK, Lai CC, Lo FS, et al. 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