{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:00:33Z","timestamp":1757451633088,"version":"3.37.3"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,18]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Diabetic ketoacidosis (DKA) is a common complication of type 1 diabetes mellitus (T1DM). Infants and children with new-onset T1DM may present with DKA, and the risk of cerebral edema is high in infantile DKA.<\/jats:p><\/jats:sec>What is new?<\/jats:title>Neurological deterioration during an episode of DKA is usually attributed to cerebral edema and cerebrovascular accidents. However, cerebral infarction is a very rare complication in infantile DKA.<\/jats:p><\/jats:sec>Case presentation<\/jats:title>We describe a rare case of infantile cerebral infarction caused by severe DKA in a patient with new-onset T1DM.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Cerebral infarction is an important intracranial complication in infantile DKA. Careful observation and treatment for DKA during the first 24 h of therapy are necessary in infants with new-onset T1DM because the risk of cerebral infarction is highest during this timeframe.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2019-0233","type":"journal-article","created":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T16:19:46Z","timestamp":1567268386000},"page":"1391-1394","source":"Crossref","is-referenced-by-count":1,"title":["Infantile cerebral infarction caused by severe diabetic ketoacidosis in new-onset type 1 diabetes mellitus"],"prefix":"10.1515","volume":"32","author":[{"given":"Junichi","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Fuchigami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7145-4136","authenticated-orcid":false,"given":"Kengo","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuhiko","family":"Urakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Morioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref141","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1081\/ERC-120018678","article-title":"Diabetic ketoacidosis promotes a prothorombotic state","volume":"29","year":"2003","journal-title":"Endocr Res"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1097\/01.CCM.0000227182.51591.21","article-title":"Cerebral hyperemia and impaired cerebral autoregulation associated with diabetic ketoacidosis in critically ill children","volume":"34","year":"2006","journal-title":"Crit Care Med"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/pedi.12165","article-title":"A Consensus Statement from the International Society for Pediatric and Adolescent Diabetes: diabetic ketoacidosis and hyperglycemic hyperosmolar state","volume":"15","year":"2014","journal-title":"Pediatr Diabetes"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1097\/01.CCM.0000227182.51591.21","article-title":"Cerebral hyperemia and impaired cerebral autoregulation associated with diabetic ketoacidosis in critically ill children","volume":"34","year":"2006","journal-title":"Crit Care Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/1056-8727(94)00058-1","article-title":"Brain infarction in children with diabetic ketoacidosis","volume":"10","year":"1996","journal-title":"J Diabetes Complicat"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/1056-8727(94)00058-1","article-title":"Brain infarction in children with diabetic ketoacidosis","volume":"10","year":"1996","journal-title":"J Diabetes Complicat"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/jcu.1870230903","article-title":"Transcranial Doppler ultrasound assessment of intracranial hemodynamics in children with diabetic ketoacidosis","volume":"23","year":"1995","journal-title":"J Clin Ultrasound"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1055\/s-0037-1613839","article-title":"Rapid change of platelet aggregability in acute hyperglycemia. 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