{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:57:35Z","timestamp":1777381055024,"version":"3.51.4"},"reference-count":82,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpem-2019-0240_s_999\"><jats:title id=\"d1913515e30503\">Background<\/jats:title><jats:p>Anorexia nervosa (AN) is a serious eating disorder that is associated with decreased bone mineral density (BMD) and greater lifetime risk for fractures. The aim of this study was to determine the correlation between BMD and genetic polymorphisms in AN.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2019-0240_s_998\"><jats:title id=\"d1913515e30511\">Methods<\/jats:title><jats:p>This case-control study analyzed vitamin D receptor (VDR) (VDRBsml, VDRFokl) and estrogen receptor (ESR) (ESR1Xbal, ESR1Pvull) polymorphisms in 45 adolescents diagnosed with AN and 46 age-matched healthy controls. BMD values of the AN group were classified as low or normal, and polymorphisms were compared between cases and controls. The effects of body mass index (BMI), duration of disease and amenorrhea on BMD were also evaluated.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2019-0240_s_997\"><jats:title id=\"d1913515e30519\">Results<\/jats:title><jats:p>In girls with AN, a positive effect of the bb genotype of VDRBsmI polymorphism on femur Z-scores (p\u2009=\u20090.103) and of the Ff genotype of VDRFokI polymorphism on vertebra Z-scores (p\u2009=\u20090.097) was observed. In boys with AN, a positive effect of the Ff genotype of VDRFokI polymorphism on vertebra BMD (g\/cm<jats:sup>2<\/jats:sup>) was detected (p\u2009=\u20090.061). No association was detected between ESR polymorphisms. An inverse relationship was observed between BMD and duration of illness and amenorrhea. A direct relationship was detected between BMD and BMI.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2019-0240_s_996\"><jats:title id=\"d1913515e30530\">Conclusions<\/jats:title><jats:p>Specific VDR gene polymorphism genotypes may have positive effects on BMD in patients with AN. Additionally, the lack of association between ESR gene polymorphisms on BMD could be attributed to the low estrogen status of the patient.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2019-0240","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T09:03:47Z","timestamp":1573549427000},"page":"1377-1384","source":"Crossref","is-referenced-by-count":3,"title":["Effects of vitamin D and estrogen receptor polymorphisms on bone mineral density in adolescents with anorexia nervosa"],"prefix":"10.1515","volume":"32","author":[{"given":"I\u015f\u0131l","family":"\u0130nan-Erdo\u011fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8203-2337","authenticated-orcid":false,"given":"Sinem","family":"Akg\u00fcl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00fcbra","family":"I\u015fg\u0131n-At\u0131c\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu\u011fba","family":"Tu\u011frul-Y\u00fccel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koray","family":"Boduro\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orhan","family":"Derman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuray","family":"Kanbur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref251","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/MOP.0b013e32831ec338","article-title":"Measurement of bone density in the pediatric population","volume":"21","year":"2009","journal-title":"Curr Opin Pediatr"},{"key":"ref841","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/eat.22248","article-title":"Fracture risk and areal bone mineral density in adolescent females with anorexia nervosa","volume":"47","year":"2014","journal-title":"Int J Eat Disord"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1176\/ajp.148.7.917","article-title":"50-Year trends in the incidence of anorexia nervosa in Rochester, Minn.: a population-based study","volume":"148","year":"1991","journal-title":"Am J Psychiatry"},{"key":"ref721","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00223-010-9425-5","article-title":"Normative calcaneal quantitative ultrasound data as an estimation of skeletal development in Swedish children and adolescents","volume":"87","year":"2010","journal-title":"Calcif Tissue Int"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/eat.22451","article-title":"State of the art systematic review of bone disease in anorexia nervosa","volume":"49","year":"2016","journal-title":"Int J Eat Disord"},{"key":"ref531","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bone.2014.05.014","article-title":"Anorexia nervosa and bone metabolism","volume":"66","year":"2014","journal-title":"Bone"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jbmr.128","article-title":"Regulation of circulating sclerostin levels by sex steroids in women and in men","volume":"26","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref621","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40200-014-0098-x","article-title":"Association between vitamin D receptor gene polymorphisms (Fok1 and Bsm1) and osteoporosis: a systematic review","volume":"13","year":"2014","journal-title":"J Diabetes Metab Disord"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1176\/ajp.148.7.917","article-title":"50-Year trends in the incidence of anorexia nervosa in Rochester, Minn.: a population-based study","volume":"148","year":"1991","journal-title":"Am J Psychiatry"},{"key":"ref501","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1210\/jc.2001-011889","article-title":"Abnormal bone mineral accrual in adolescent girls with anorexia nervosa","volume":"87","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref751","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s001980070121","article-title":"Can the WHO criteria for diagnosing osteoporosis be applied to calcaneal quantitative ultrasound?","volume":"11","year":"2000","journal-title":"Osteoporos Int"},{"key":"ref601","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/aje\/kwi055","article-title":"Estrogen receptor gene polymorphisms and the genetics of osteoporosis: a HuGE review","volume":"161","year":"2005","journal-title":"Am J Epidemiol"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1542\/peds.2014-0194","article-title":"Eating disorders in children and adolescents: state of the art review","volume":"134","year":"2014","journal-title":"Pediatrics"},{"key":"ref651","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3109\/09513590.2013.798275","article-title":"Gene receptor polymorphism as a risk factor for BMD deterioration in adolescent girls with anorexia nervosa","volume":"29","year":"2013","journal-title":"Gynecol Endocrinol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/YCO.0b013e328365a24f","article-title":"Epidemiology, course, and outcome of eating disorders","volume":"26","year":"2013","journal-title":"Curr Opin Psychiatry"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/eat.10101","article-title":"Fractures in patients with anorexia nervosa, bulimia nervosa, and other eating disorders \u2013 a nationwide register study","volume":"32","year":"2002","journal-title":"Int J Eat Disord"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/cen.12144","article-title":"Inhibition of Pref-1 (preadipocyte factor 1) by oestradiol in adolescent girls with anorexia nervosa is associated with improvement in lumbar bone mineral density","volume":"79","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/cen.12144","article-title":"Inhibition of Pref-1 (preadipocyte factor 1) by oestradiol in adolescent girls with anorexia nervosa is associated with improvement in lumbar bone mineral density","volume":"79","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref351","first-page":"2589","article-title":"Association of estrogen receptor alpha gene polymorphisms with bone mineral density: a meta-analysis","volume":"125","year":"2012","journal-title":"Chin Med J (Engl)"},{"key":"ref711","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00223001090","article-title":"Comparison of quantitative calcaneal ultrasound and dual energy X-ray absorptiometry in the evaluation of osteoporotic risk in children with chronic rheumatic diseases","volume":"67","year":"2000","journal-title":"Calcif Tissue Int"},{"key":"ref861","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3109\/13697137.2011.617851","article-title":"Estrogen receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density","volume":"15","year":"2012","journal-title":"Climacteric"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1542\/peds.2010-2821","article-title":"Identification and management of eating disorders in children and adolescents","volume":"126","year":"2010","journal-title":"Pediatrics"},{"key":"ref191","first-page":"358","article-title":"Familial resemblance for bone mineral mass is expressed before puberty","volume":"83","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00223-010-9425-5","article-title":"Normative calcaneal quantitative ultrasound data as an estimation of skeletal development in Swedish children and adolescents","volume":"87","year":"2010","journal-title":"Calcif Tissue Int"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1542\/peds.2004-0540","article-title":"Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls","volume":"114","year":"2004","journal-title":"Pediatrics"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/01.mph.0000212946.28103.29","article-title":"A pilot study of heel ultrasound to screen for low bone mass in children with leukemia","volume":"28","year":"2006","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1097\/00004583-200011000-00010","article-title":"Predictors of bone mineral density reduction in adolescents with anorexia nervosa","volume":"39","year":"2000","journal-title":"J Am Acad Child Adolesc Psychiat"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/eat.20118","article-title":"Medical complications in adolescents with anorexia nervosa: a review of the literature","volume":"37","year":"2005","journal-title":"Int J Eat Disord"},{"key":"ref701","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.bone.2007.07.008","article-title":"Osteoporosis in children and adolescents","volume":"41","year":"2007","journal-title":"Bone"},{"key":"ref561","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1172\/JCI11468","article-title":"The mechanisms of estrogen regulation of bone resorption","volume":"106","year":"2000","journal-title":"J Clin Invest"},{"key":"ref491","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1530\/JOE-14-0039","article-title":"Anorexia nervosa and bone","volume":"221","year":"2014","journal-title":"J Endocrinol"},{"key":"ref591","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.4238\/2015.February.13.8","article-title":"Estrogen receptor alpha gene PvuII polymorphism and risk of fracture in postmenopausal women: a meta-analysis","volume":"14","year":"2015","journal-title":"Genet Mol Res"},{"key":"ref201","first-page":"479","article-title":"Vitamin D receptor gene start codon polymorphism (FokI) is associated with forearm bone mineral density and calcaneal ultrasound in Finnish adolescent boys but not in girls","volume":"22","year":"2004","journal-title":"J Bone Miner Metab"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0140-6736(09)61748-7","article-title":"Eating disorders","volume":"375","year":"2010","journal-title":"Lancet"},{"key":"ref511","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/eat.10101","article-title":"Fractures in patients with anorexia nervosa, bulimia nervosa, and other eating disorders \u2013 a nationwide register study","volume":"32","year":"2002","journal-title":"Int J Eat Disord"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1172\/JCI11468","article-title":"The mechanisms of estrogen regulation of bone resorption","volume":"106","year":"2000","journal-title":"J Clin Invest"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0303-7207(02)00274-5","article-title":"The role of vitamin D receptor gene polymorphisms in bone biology","volume":"197","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00223001090","article-title":"Comparison of quantitative calcaneal ultrasound and dual energy X-ray absorptiometry in the evaluation of osteoporotic risk in children with chronic rheumatic diseases","volume":"67","year":"2000","journal-title":"Calcif Tissue Int"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00592-011-0284-y","article-title":"Vitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patients","volume":"48","year":"2011","journal-title":"Acta Diabetol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1542\/peds.2010-2821","article-title":"Identification and management of eating disorders in children and adolescents","volume":"126","year":"2010","journal-title":"Pediatrics"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/jbmr.5650110304","article-title":"Association of bone mineral density with polymorphism of the estrogen receptor gene","volume":"11","year":"1996","journal-title":"J Bone Miner Res"},{"key":"ref791","first-page":"2589","article-title":"Association of estrogen receptor alpha gene polymorphisms with bone mineral density: a meta-analysis","volume":"125","year":"2012","journal-title":"Chin Med J (Engl)"},{"key":"ref821","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1097\/00004583-200011000-00010","article-title":"Predictors of bone mineral density reduction in adolescents with anorexia nervosa","volume":"39","year":"2000","journal-title":"J Am Acad Child Adolesc Psychiat"},{"key":"ref801","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1359\/jbmr.2002.17.11.2048","article-title":"Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density and fracture risk in women: a meta-analysis","volume":"17","year":"2002","journal-title":"J Bone Miner Res"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.4238\/2015.February.13.8","article-title":"Estrogen receptor alpha gene PvuII polymorphism and risk of fracture in postmenopausal women: a meta-analysis","volume":"14","year":"2015","journal-title":"Genet Mol Res"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3109\/13697137.2011.617851","article-title":"Estrogen receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density","volume":"15","year":"2012","journal-title":"Climacteric"},{"key":"ref551","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1542\/peds.2004-0540","article-title":"Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls","volume":"114","year":"2004","journal-title":"Pediatrics"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/aje\/kwi055","article-title":"Estrogen receptor gene polymorphisms and the genetics of osteoporosis: a HuGE review","volume":"161","year":"2005","journal-title":"Am J Epidemiol"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3109\/09513590.2013.798275","article-title":"Gene receptor polymorphism as a risk factor for BMD deterioration in adolescent girls with anorexia nervosa","volume":"29","year":"2013","journal-title":"Gynecol Endocrinol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1210\/jc.2001-011889","article-title":"Abnormal bone mineral accrual in adolescent girls with anorexia nervosa","volume":"87","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jbmr.128","article-title":"Regulation of circulating sclerostin levels by sex steroids in women and in men","volume":"26","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1542\/peds.2014-0194","article-title":"Eating disorders in children and adolescents: state of the art review","volume":"134","year":"2014","journal-title":"Pediatrics"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12902-018-0230-x","article-title":"Associations between ER\u03b1\/\u03b2 gene polymorphisms and osteoporosis susceptibility and bone mineral density in postmenopausal women: a systematic review and meta-analysis","volume":"18","year":"2018","journal-title":"BMC Endocr Disord"},{"key":"ref831","first-page":"115","article-title":"Correlates of low bone density in females with anorexia nervosa","volume":"18","year":"2017","journal-title":"J Adolesc Heal"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"6723","DOI":"10.1007\/s11033-012-1496-0","article-title":"Evaluation of ER and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women","volume":"39","year":"2012","journal-title":"Mol Biol Rep"},{"key":"ref631","first-page":"358","article-title":"Familial resemblance for bone mineral mass is expressed before puberty","volume":"83","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref641","first-page":"479","article-title":"Vitamin D receptor gene start codon polymorphism (FokI) is associated with forearm bone mineral density and calcaneal ultrasound in Finnish adolescent boys but not in girls","volume":"22","year":"2004","journal-title":"J Bone Miner Metab"},{"key":"ref771","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/jbmr.5650110304","article-title":"Association of bone mineral density with polymorphism of the estrogen receptor gene","volume":"11","year":"1996","journal-title":"J Bone Miner Res"},{"key":"ref811","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12902-018-0230-x","article-title":"Associations between ER\u03b1\/\u03b2 gene polymorphisms and osteoporosis susceptibility and bone mineral density in postmenopausal women: a systematic review and meta-analysis","volume":"18","year":"2018","journal-title":"BMC Endocr Disord"},{"key":"ref391","first-page":"115","article-title":"Correlates of low bone density in females with anorexia nervosa","volume":"18","year":"2017","journal-title":"J Adolesc Heal"},{"key":"ref871","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00592-011-0284-y","article-title":"Vitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patients","volume":"48","year":"2011","journal-title":"Acta Diabetol"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.nutr.18.1.233","article-title":"The genetics of osteoporosis: vitamin D receptor polymorphisms","volume":"18","year":"1998","journal-title":"Annu Rev Nutr"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/eat.22248","article-title":"Fracture risk and areal bone mineral density in adolescent females with anorexia nervosa","volume":"47","year":"2014","journal-title":"Int J Eat Disord"},{"key":"ref611","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0303-7207(02)00274-5","article-title":"The role of vitamin D receptor gene polymorphisms in bone biology","volume":"197","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1530\/JOE-14-0039","article-title":"Anorexia nervosa and bone","volume":"221","year":"2014","journal-title":"J Endocrinol"},{"key":"ref691","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/MOP.0b013e32831ec338","article-title":"Measurement of bone density in the pediatric population","volume":"21","year":"2009","journal-title":"Curr Opin Pediatr"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0140-6736(09)61748-7","article-title":"Eating disorders","volume":"375","year":"2010","journal-title":"Lancet"},{"key":"ref781","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.nutr.18.1.233","article-title":"The genetics of osteoporosis: vitamin D receptor polymorphisms","volume":"18","year":"1998","journal-title":"Annu Rev Nutr"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s002230001143","article-title":"Ultrasound bone densitometry of the Os calcis in children and adolescents","volume":"67","year":"2000","journal-title":"Calcif Tissue Int"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bone.2014.05.014","article-title":"Anorexia nervosa and bone metabolism","volume":"66","year":"2014","journal-title":"Bone"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s001980070121","article-title":"Can the WHO criteria for diagnosing osteoporosis be applied to calcaneal quantitative ultrasound?","volume":"11","year":"2000","journal-title":"Osteoporos Int"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/YCO.0b013e328365a24f","article-title":"Epidemiology, course, and outcome of eating disorders","volume":"26","year":"2013","journal-title":"Curr Opin Psychiatry"},{"key":"ref731","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s002230001143","article-title":"Ultrasound bone densitometry of the Os calcis in children and adolescents","volume":"67","year":"2000","journal-title":"Calcif Tissue Int"},{"key":"ref761","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jocd.2007.12.002","article-title":"Official positions of the International Society for Clinical Densitometry and executive summary of the 2007 ISCD Pediatric Position Development Conference","volume":"11","year":"2008","journal-title":"J Clin Densitom"},{"key":"ref741","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/01.mph.0000212946.28103.29","article-title":"A pilot study of heel ultrasound to screen for low bone mass in children with leukemia","volume":"28","year":"2006","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40200-014-0098-x","article-title":"Association between vitamin D receptor gene polymorphisms (Fok1 and Bsm1) and osteoporosis: a systematic review","volume":"13","year":"2014","journal-title":"J Diabetes Metab Disord"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/eat.20118","article-title":"Medical complications in adolescents with anorexia nervosa: a review of the literature","volume":"37","year":"2005","journal-title":"Int J Eat Disord"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jocd.2007.12.002","article-title":"Official positions of the International Society for Clinical Densitometry and executive summary of the 2007 ISCD Pediatric Position Development Conference","volume":"11","year":"2008","journal-title":"J Clin Densitom"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/eat.22451","article-title":"State of the art systematic review of bone disease in anorexia nervosa","volume":"49","year":"2016","journal-title":"Int J Eat Disord"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1359\/jbmr.2002.17.11.2048","article-title":"Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density and fracture risk in women: a meta-analysis","volume":"17","year":"2002","journal-title":"J Bone Miner Res"},{"key":"ref851","doi-asserted-by":"crossref","first-page":"6723","DOI":"10.1007\/s11033-012-1496-0","article-title":"Evaluation of ER and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women","volume":"39","year":"2012","journal-title":"Mol Biol Rep"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.bone.2007.07.008","article-title":"Osteoporosis in children and adolescents","volume":"41","year":"2007","journal-title":"Bone"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jpem.2019.32.issue-12\/jpem-2019-0240\/jpem-2019-0240.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2019-0240\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T19:20:46Z","timestamp":1722021646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2019-0240\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,18]]},"references-count":82,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.1515\/jpem-2019-0240","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12,18]]}}}