{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:22:55Z","timestamp":1788952975172,"version":"build-2803163510"},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2019-0378_s_999_w2aab3b7c31b1b6b1aab1c16b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We aimed to assess whether age at menarche and pubertal development (Tanner stage) are related to gluten-free diet (GFD) adherence, hormonal status, micro-nutrient levels and body mass index (BMI) in children with celiac disease (CD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0378_s_998_w2aab3b7c31b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this two-center, cross-sectional study, CD patients and healthy individuals were studied. CD patients were re-evaluated after 1 year of follow-up. Height, weight, Tanner stage, age at menarche and diet compliance were recorded. Blood samples for anti-tissue transglutaminase IgA (TTG), pituitary gonadotropins, gonadal hormones, prolactin and micronutrients (folate, vitamin B12, vitamin D, ferritin, iron and, iron-binding capacity [IBC]) were assayed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0378_s_997_w2aab3b7c31b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Consecutive age- and sex-matched 228 celiac patients (12.92\u2009\u00b1\u20092.35 years; 67.9% female) and 135 non-celiac healthy individuals (12.77\u2009\u00b1\u20092.25 years; 65.2% female) were studied. Tanner stage was significantly higher in the control group for both girls and boys (p\u2009&lt;\u20090.05). The mean age at menarche was significantly lower in healthy individuals (13.13\u2009\u00b1\u20091.01 vs. 12.15\u2009\u00b1\u20090.97, p\u2009&lt;\u20090.001). By multivariate analysis, GFD adherence, transferrin saturation (sTrf), total IBC (TIBC) and vitamin D status were found to be positively correlated with Tanner stage (p\u2009&lt;\u20090.05). After 1 year, 192 of the CD patients were re-evaluated. GFD compliance was better (TTG levels: 135.59\u2009\u00b1\u200973.88 vs. 71.53\u2009\u00b1\u200969.40, p\u2009&lt;\u20090.001) and it was correlated with Tanner stage (r\u2009=\u20090.49, p\u2009&lt;\u20090.01), sTrf (r\u2009=\u20090.66, p\u2009&lt;\u20090.01) and IBC (r\u2009=\u20090.23, p\u2009&lt;\u20090.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0378_s_996_w2aab3b7c31b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our data show that adequate weight gain, adherence to GFD, sufficient iron and vitamin D status are essential factors for salubrious puberty in CD patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2019-0378","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T09:03:21Z","timestamp":1582016601000},"page":"409-415","source":"Crossref","is-referenced-by-count":11,"title":["The effect of celiac disease and gluten-free diet on pubertal development: a two-center study"],"prefix":"10.1515","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5553-6123","authenticated-orcid":false,"given":"Nevzat Aykut","family":"Bayrak","sequence":"first","affiliation":[{"name":"Zeynep Kamil Women and Children\u2019s Hospital, Department of Pediatric Gastroenterology , Istanbul , Turkey"},{"name":"Pediatric Gastroenterology, Hepatology and Nutrition, Diyarbakir Children\u2019s Hospital , Diyarbakir , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu","family":"Volkan","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology and Nutrition, Erzurum Regional Training and Research Hospital , Erzurum , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belma","family":"Haliloglu","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Diyarbakir Children\u2019s Hospital , Diyarbakir , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soner Sertan","family":"Kara","sequence":"additional","affiliation":[{"name":"Pediatrics, Erzurum Regional Training and Research Hospital , Erzurum , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atilla","family":"Cayir","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Erzurum Regional Training and Research Hospital , Erzurum , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"2023040101053357920_j_jpem-2019-0378_ref_001_w2aab3b7c31b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Husby S, Koletzko S, Korponay-Szab\u00f3 IR, Mearin ML, Phillips A, et al. 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