{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:44:26Z","timestamp":1790376266043,"version":"4.1.0"},"reference-count":38,"publisher":"Walter de Gruyter GmbH","issue":"7","funder":[{"name":"Pfizer Spain"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2019-0438_abs_001_w2aab3b7c10b1b6b1aab1c15b2Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To study the efficacy and influence on metabolism of recombinant human growth hormone (rhGH) treatment in short children born small for gestational age (SGA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0438_abs_002_w2aab3b7c10b1b6b1aab1c15b3Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective, observational, multicenter study in 305 short children born SGA, treated with rhGH during a mean\u00a0\u00b1\u00a0SD of 5.03\u00a0\u00b1\u00a01.73\u00a0years\u00a0at a mean\u00a0\u00b1\u00a0SD dose of 37\u00a0\u00b1\u00a08\u00a0\u03bcg\/kg\/day. Auxological and metabolic assessment including glucose and lipids profile were collected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0438_abs_003_w2aab3b7c10b1b6b1aab1c15b4Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mean\u00a0\u00b1\u00a0SD age at the start of treatment was 7.11\u00a0\u00b1\u00a02.78 years. Height and weight improved significantly until the end of treatment from mean\u00a0\u22122.72 (CI<jats:sub>95%<\/jats:sub>:\u00a0\u22122.81 to \u22122.63) standard deviation score (SDS) to\u00a0\u22121.16 (CI<jats:sub>95%<\/jats:sub>:\u00a0\u22121.44 to \u22120.88) SDS and from\u00a0\u22121.62 (CI<jats:sub>95%<\/jats:sub>:\u00a0\u22121.69 to \u22121.55) SDS to\u00a0\u22120.94 (CI<jats:sub>95%<\/jats:sub>:\u00a0\u22121.14 to \u22120.74) SDS respectively. Mean height gain was 1.27 (CI<jats:sub>95%<\/jats:sub>: 0.99\u20131.54) SDS. Prepubertal patients showed higher height gain than pubertal children (mean [CI<jats:sub>95%<\/jats:sub>]\u00a0=\u00a01.44 [CI<jats:sub>95%<\/jats:sub>: 1.14\u20131.74] vs. 0.73 [CI<jats:sub>95%<\/jats:sub>: 0.22\u20131.24], p=0.02). Height gain SDS during treatment negatively correlated with chronological age (CA) and bone age (BA) delay and positively correlated with duration of treatment, height gain during first year of treatment, years on prepubertal treatment and height SDS from target height (TH). Glucose, insulin, and triglycerides increased significantly but remained within the normal range. Total and LDL-cholesterol decreased significantly, and HDL-cholesterol remained unchanged.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0438_abs_004_w2aab3b7c10b1b6b1aab1c15b5Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>rhGH treatment in short SGA children effectively normalized height in most of the patients and showed a safe metabolic profile. Children who benefit the most are those with greater height SDS distance from TH, BA delay, longer duration of treatment and prepubertal treatment initiation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2019-0438","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T12:57:09Z","timestamp":1594385829000},"page":"923-932","source":"Crossref","is-referenced-by-count":12,"title":["Growth and metabolic effects of long-term recombinant human growth hormone (rhGH) treatment in short children born small for gestational age: GH-RAST study"],"prefix":"10.1515","volume":"33","author":[{"given":"Jos\u00e9 I.","family":"Labarta","sequence":"first","affiliation":[{"name":"Hospital Universitario Miguel Servet , Zaragoza , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"de Arriba","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet , Zaragoza , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet , Zaragoza , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Loranca","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico1 , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Martos","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen de la Arrixaca , Murcia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Gregorio Mara\u00f1\u00f3n , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luz","family":"Samaniego","sequence":"additional","affiliation":[{"name":"TFS Statistical Services , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8554-7413","authenticated-orcid":false,"given":"Laura","family":"S\u00e1nchez-Cenizo","sequence":"additional","affiliation":[{"name":"Pfizer S.L.U. , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,7,5]]},"reference":[{"key":"2023040101122168984_j_jpem-2019-0438_ref_001_w2aab3b7c10b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Albertsson-Wikland, K, Boguszewski, M, Karlberg, J. Children born small-for-gestational age: postnatal growth and hormonal status. Horm Res 1998;49:7\u201313. https:\/\/doi.org\/10.1159\/000053080.","DOI":"10.1159\/000053080"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_002_w2aab3b7c10b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Clayton, P, Cianfarani, S, Czernichow, P, Johannsson, G, Rapaport, R, Rogol, A. Management of the child born small for gestational age through to adulthood: a consensus statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society. J Clin Endocrinol Metab 2007;92:804\u201310. https:\/\/doi.org\/10.1210\/jc.2006-2017.","DOI":"10.1210\/jc.2006-2017"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_003_w2aab3b7c10b1b6b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Saenger, P, Czernichow, P, Hughes, I, Reiter, E. Small for gestational age: short stature and beyond. Endocr Rev 2007;28:219\u201351. https:\/\/doi.org\/10.1210\/er.2006-0039.","DOI":"10.1210\/er.2006-0039"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_004_w2aab3b7c10b1b6b1ab2b2b4Aa","doi-asserted-by":"crossref","unstructured":"Ranke, M, Lindberg, A, Board, KI. Prediction models for short children born small for gestational age (SGA) covering the total growth phase. Analyses based on data from KIGS (Pfizer International Growth Database). BMC Med Inf Decis Making 2011;11. https:\/\/doi.org\/10.1186\/1472-6947-11-38.","DOI":"10.1186\/1472-6947-11-38"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_005_w2aab3b7c10b1b6b1ab2b2b5Aa","doi-asserted-by":"crossref","unstructured":"Loftus, J, Lindberg, A, Aydin, F, Gomez, R, Maghnie, M, Rooman, R, et al. Individualised growth response optimisation (iGRO) tool: an accessible and easy-to-use growth prediction system to enable treatment optimisation for children treated with growth hormone. J Pediatr Endocrinol Metab 2017;30:1019\u201328. https:\/\/doi.org\/10.1515\/jpem-2017-0120.","DOI":"10.1515\/jpem-2017-0120"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_006_w2aab3b7c10b1b6b1ab2b2b6Aa","doi-asserted-by":"crossref","unstructured":"Cutfield, W, Lindberg, A, Rapaport, R, Wajnrajch, M, Saenger, P. Safety of growth hormone treatment in children born small for gestational age: the US trial and KIGS analysis. Horm Res 2006;65:153\u20139. https:\/\/doi.org\/10.1159\/000091719.","DOI":"10.1159\/000091719"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_007_w2aab3b7c10b1b6b1ab2b2b7Aa","doi-asserted-by":"crossref","unstructured":"Sas, T, Mulder, P, Aanstoot, H, Houdijk, M, Jansen, M, Reeser, M, et al. Carbohydrate metabolism during long-term growth hormone treatment in children with short stature born small for gestational age. Clin Endocrinol (Oxf). 2001;54:243\u201351. https:\/\/doi.org\/10.1046\/j.1365-2265.2001.01178.x.","DOI":"10.1046\/j.1365-2265.2001.01178.x"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_008_w2aab3b7c10b1b6b1ab2b2b8Aa","doi-asserted-by":"crossref","unstructured":"Sas, T, Mulder, P, Hokken-Koelega, A. Body composition, blood pressure, and lipid metabolism before and during long-term growth hormone (GH) treatment in children with short stature born small for gestational age either with or without GH deficiency. J Clin Endocrinol Metab 2000;85:3786\u201392. https:\/\/doi.org\/10.1210\/jcem.85.10.6917.","DOI":"10.1210\/jc.85.10.3786"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_009_w2aab3b7c10b1b6b1ab2b2b9Aa","doi-asserted-by":"crossref","unstructured":"Greulich, W, Pyle, S. Radiographic Atlas of Skeletal Development of the Hand and Wrist. Stanford: Stanford University Press; 1959:p.\u00a0272.","DOI":"10.1097\/00000441-195909000-00030"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_010_w2aab3b7c10b1b6b1ab2b2c10Aa","unstructured":"Tanner, J, Whitehouse, R, Cameron, N, Marshall, W, Healy, M, Goldstein, H. Assessment of skeletal maturity and prediction of adult height (TW2 method), 2nd ed. London: Academic Press; 1983."},{"key":"2023040101122168984_j_jpem-2019-0438_ref_011_w2aab3b7c10b1b6b1ab2b2c11Aa","doi-asserted-by":"crossref","unstructured":"Tanner, J, Goldstein, H, Whitehouse, R. Standards for children\u2019s height at ages 2\u20139 years allowing for heights of parents. Arch Dis Child 1970;45:755\u201362. https:\/\/doi.org\/10.1136\/adc.45.244.755.","DOI":"10.1136\/adc.45.244.755"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_012_w2aab3b7c10b1b6b1ab2b2c12Aa","doi-asserted-by":"crossref","unstructured":"Carrascosa Lezcano, A, Ferr\u00e1ndez Long\u00e1s, A, Yeste Fern\u00e1ndez, D, Garc\u00eda-Dihinx Villanova, J, Romo Montejo, A, Copil Copil, A, et al. Spanish cross-sectional growth study 2008. Part I: weight and height values in newborns of 26-42\u00a0weeks of gestational age. An Pediatr (Barc) 2008;68:544\u201351. https:\/\/doi.org\/10.1157\/13123286.","DOI":"10.1157\/13123286"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_013_w2aab3b7c10b1b6b1ab2b2c13Aa","doi-asserted-by":"crossref","unstructured":"Carrascosa Lezcano, A, Fern\u00e1ndez Garc\u00eda, J, Fern\u00e1ndez Ramos, C, Fern\u00e1ndez Long\u00e1s, A, L\u00f3pez-Siguero, J, S\u00e1nchez Gonz\u00e1lez, E, et al. Spanish cross-sectional growth study 2008. Part II. Height, weight and body mass index values from birth to adulthood. An Pediatr (Barc). 2008;68:552\u201369. https:\/\/doi.org\/10.1157\/13123287.","DOI":"10.1157\/13123287"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_014_w2aab3b7c10b1b6b1ab2b2c14Aa","doi-asserted-by":"crossref","unstructured":"Sas, T, de Waal, W, Mulder, P, Houdijk, M, Jansen, M, Reeser, M, et al. Growth hormone treatment in children with short stature born small for gestational age: 5-year results of a randomized, double-blind, dose-response trial. J Clin Endocrinol Metab 1999;84:3064\u201370. https:\/\/doi.org\/10.1210\/jcem.84.9.5942.","DOI":"10.1210\/jc.84.9.3064"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_015_w2aab3b7c10b1b6b1ab2b2c15Aa","doi-asserted-by":"crossref","unstructured":"Chatelain, P, Carrascosa, A, Bona, G, Fern\u00e1ndez Long\u00e1s, A, Sippell, W. Growth hormone therapy for short children born small for gestational age. Horm Res 2007;68:300\u20139. https:\/\/doi.org\/10.1159\/000107935.","DOI":"10.1159\/000107935"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_016_w2aab3b7c10b1b6b1ab2b2c16Aa","doi-asserted-by":"crossref","unstructured":"Maiorana, A, Cianfarani, S. Impact of growth hormone therapy on adult height of children born small for gestational age. Pediatrics 2009;124:519. https:\/\/doi.org\/10.1542\/peds.2009-0293.","DOI":"10.1542\/peds.2009-0293"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_017_w2aab3b7c10b1b6b1ab2b2c17Aa","doi-asserted-by":"crossref","unstructured":"Hwang, I. Efficacy and safety of growth hormone treatment for children born small for gestational age. Korean J Pediatr 2014;57:379\u201383. https:\/\/doi.org\/10.3345\/kjp.2014.57.9.379.","DOI":"10.3345\/kjp.2014.57.9.379"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_018_w2aab3b7c10b1b6b1ab2b2c18Aa","doi-asserted-by":"crossref","unstructured":"Fejellestad-Paulsen, A, Simon, D, Czernichow, P. Short children born small for gestational age and treated with growth hormone for three years have an important catch-down five years after discontinuation of treatment. J Clin Endocrinol Metab 2004;89:1234\u20139. https:\/\/doi.org\/10.1210\/jc.2003-030962.","DOI":"10.1210\/jc.2003-030962"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_019_w2aab3b7c10b1b6b1ab2b2c19Aa","doi-asserted-by":"crossref","unstructured":"De Zegher, F, Maes, M, Gargosky, S, Heinrichs, C, Du Caju, M, Thiry, G, et al. High-dose growth hormone treatment of short children born small for gestational age. J Clin Endocrinol Metab 1996;81:1887\u201392. https:\/\/doi.org\/10.1210\/jc.81.5.1887.","DOI":"10.1210\/jcem.81.5.8626853"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_020_w2aab3b7c10b1b6b1ab2b2c20Aa","doi-asserted-by":"crossref","unstructured":"Boguszewski, M, Lindberg, A, Wollmann, H. Three-year growth response to growth hormone treatment in very young children born small for gestational age. Data from KIGS. J Clin Endocrinol Metab 2014;99:2683\u20138. https:\/\/doi.org\/10.1210\/jc.2013-4117.","DOI":"10.1210\/jc.2013-4117"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_021_w2aab3b7c10b1b6b1ab2b2c21Aa","doi-asserted-by":"crossref","unstructured":"Kristr\u00f6m, B, Dahlgren, J, Niklasson, A, Nierop, A, Albertsson-Wikland, K. The first-year growth response to growth hormone treatment predicts the long-term prepubertal growth response in children. BMC Med Inf Decis Making 2009;9. https:\/\/doi.org\/10.1186\/1472-6947-9-1.","DOI":"10.1186\/1472-6947-9-1"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_022_w2aab3b7c10b1b6b1ab2b2c22Aa","doi-asserted-by":"crossref","unstructured":"Carrascosa Lezcano, A, Aud\u00ed, L, Esteban, C, Fern\u00e1ndez-Cancio, M, Andaluz, P, Guissiny\u00e9, M, et al. Growth hormone (GH) dose, but not exon 3-deleted\/full-lenth receptor polymorphism genotypes, influences growth response to two-year GH therapy in short small-for-gestational-age children. J Clin Endocrinol Metab 2008;93:147\u201353. https:\/\/doi.org\/10.1210\/jc.2007-1182.","DOI":"10.1210\/jc.2007-1182"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_023_w2aab3b7c10b1b6b1ab2b2c23Aa","doi-asserted-by":"crossref","unstructured":"Ranke, M, Lindberg, A, Cowell, C, Wikland, K, Reiter, E, Wilton, P, et al. Prediction of response to growth hormone treatment in short children born small for gestational age: analysis of data from KIGS (Pharmacia International Growth Database). J Clin Endocrinol Metab 2003;88:125\u201331. https:\/\/doi.org\/10.1210\/jc.2002-020867.","DOI":"10.1210\/jc.2002-020867"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_024_w2aab3b7c10b1b6b1ab2b2c24Aa","doi-asserted-by":"crossref","unstructured":"Dahlgren, J, Wikland, KA, Swedish Study Group for Growth Hormone Treatment. Final height in short children born small for gestational age treated with growth hormone. Pediatr Res 2005;57:216\u201322. https:\/\/doi.org\/10.1203\/01.pdr.0000148716.71231.81.","DOI":"10.1203\/01.PDR.0000148716.71231.81"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_025_w2aab3b7c10b1b6b1ab2b2c25Aa","doi-asserted-by":"crossref","unstructured":"Arends, N, Boonstra, V, Mulder, P, Odink, R, Stokvis-Brantsma, W, Rongen-Westerlaken, C, et al. GH treatment and its effect on bone mineral density, bone maturation and growth in short children born small for gestational age: 3-year results of a randomized, controlled GH trial. Clin Endocrinol (Oxf) 2003;59:779\u201387. https:\/\/doi.org\/10.1046\/j.1365-2265.2003.01905.x.","DOI":"10.1046\/j.1365-2265.2003.01905.x"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_026_w2aab3b7c10b1b6b1ab2b2c26Aa","doi-asserted-by":"crossref","unstructured":"Horikawa, R, Tanaka, T, Nishinaga, H, Ogawa, Y, Yokoya, S. Evaluation of growth hormone treatment efficacy in short Japanese children born small for gestational age: five-year treatment outcome and impact on puberty. Clin Pediatr Endocrinol 2017;26:63\u201372. https:\/\/doi.org\/10.1297\/cpe.26.63.","DOI":"10.1297\/cpe.26.63"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_027_w2aab3b7c10b1b6b1ab2b2c27Aa","doi-asserted-by":"crossref","unstructured":"Coutant, R, Carel, J, Letrait, M, Bouvattier, C, Chatelain, P, Coste, J, et al. Short stature associated with intrauterine growth retardation: final height of untreated and growth hormone-treated children. J Clin Endocrinol Metab 1998;83:1070\u20134. https:\/\/doi.org\/10.1210\/jcem.83.4.4750.","DOI":"10.1210\/jcem.83.4.4750"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_028_w2aab3b7c10b1b6b1ab2b2c28Aa","doi-asserted-by":"crossref","unstructured":"Ranke, MAL. Growth hormone treatment of short children born small for gestational age or with Silver-Russell syndrome: results from KIGS (Kabi International Growth Study), including the first report on final height. Acta Paediatr Suppl 1996;417:18\u201326. https:\/\/doi.org\/10.1111\/j.1651-2227.1996.tb14288.x.","DOI":"10.1111\/j.1651-2227.1996.tb14288.x"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_029_w2aab3b7c10b1b6b1ab2b2c29Aa","doi-asserted-by":"crossref","unstructured":"Zucchini, S, Cacciari, E, Balsamo, A, Cicognani, A, Tassinari, D, Barbieri, E, et al. Final height of short subjects of low birth weight with and without growth hormone treatment. Arch Dis Child 2001;84:340\u20133. https:\/\/doi.org\/10.1136\/adc.84.4.340.","DOI":"10.1136\/adc.84.4.340"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_030_w2aab3b7c10b1b6b1ab2b2c30Aa","doi-asserted-by":"crossref","unstructured":"Van Pareren, Y, Mulder, P, Houdijk, M, Jansen, M, Reeser, M, Hokken-Koelega, A. Adult height after long-term, continuous growth hormone (GH) treatment in short children born small for gestational age: results of a randomized, double-blind, dose-response GH trial. J Clin Endocrinol Metab 2003;88:3584\u201390. https:\/\/doi.org\/10.1210\/jc.2002-021172.","DOI":"10.1210\/jc.2002-021172"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_031_w2aab3b7c10b1b6b1ab2b2c31Aa","doi-asserted-by":"crossref","unstructured":"De Zegher, F, Du Caju, M, Heinrichs, C, Maes, M, De Schepper, J, Craen, M, et al. Early, discontinous, high dose growth hormone treatment to normalize height and weight of short children born small for gestational age: results over 6 years. J Clin Endocrinol Metab 1999;84:1558\u201361. https:\/\/doi.org\/10.1210\/jcem.84.5.5697.","DOI":"10.1210\/jcem.84.5.5697"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_032_w2aab3b7c10b1b6b1ab2b2c32Aa","doi-asserted-by":"crossref","unstructured":"Ranke, M, Lindberg, A. Height at start, first-year growth response and cause of shortness at birth are major determinants of adult height outcomes of short children born small for gestational age and Silver-Russell syndrome treated with growth hormone: analysis of data from KIGS. Horm Res Paediatr 2010;74:259\u201366. https:\/\/doi.org\/10.1159\/000289570.","DOI":"10.1159\/000289570"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_033_w2aab3b7c10b1b6b1ab2b2c33Aa","doi-asserted-by":"crossref","unstructured":"Reiter, E, Price, D, Wilton, P, Albertsson-Wikland, K, Ranke, M. Effect of growth hormone (GH) treatment on the near-final height of 1258 patients with idiopathic GH deficiency: analysis of a large international database. J Clin Endocrinol Metab 2006;91:2047\u201354. https:\/\/doi.org\/10.1210\/jc.2005-2284.","DOI":"10.1210\/jc.2005-2284"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_034_w2aab3b7c10b1b6b1ab2b2c34Aa","doi-asserted-by":"crossref","unstructured":"Ranke, M, Lindberg, A, Price, D, Darendeliler, F, Albertsson-Wikland, K, Wilton, P, et al. Age at growth hormone therapy start and first-year responsiveness to growth hormone are major determinants of height outcome in idiopathic short stature. Horm Res 2007;68:53\u201362. https:\/\/doi.org\/10.1159\/000098707.","DOI":"10.1159\/000098707"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_035_w2aab3b7c10b1b6b1ab2b2c35Aa","doi-asserted-by":"crossref","unstructured":"van Pareren, Y, Mulder, P, Houdijk, M, Jansen, M, Reeser, M, Hokken-Koelega, A. Effect of discontinuation of growth hormone treatment on risk factors for cardiovascular disease in adolescents born small for gestational age. J Clin Endocrinol Metab 2003;88:347\u201353. https:\/\/doi.org\/10.1210\/jc.2002-020458.","DOI":"10.1210\/jc.2002-020458"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_036_w2aab3b7c10b1b6b1ab2b2c36Aa","doi-asserted-by":"crossref","unstructured":"Van Dijk, M, Bannik, E, Van Pareren, Y, Mulder, P, Hokken-Koelega, A. Risk factors for diabetes mellitus type 2 and metabolic syndrome are comparable for previously growth hormone-treated young adults born small for gestational age (SGA) and untreated short SGA controls. J Clin Endocrinol Metab 2007;92:160\u20135. https:\/\/doi.org\/10.1210\/jc.2006-1073.","DOI":"10.1210\/jc.2006-1073"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_037_w2aab3b7c10b1b6b1ab2b2c37Aa","doi-asserted-by":"crossref","unstructured":"Rodriguez Arnao, MD, Rodriguez Sanchez, A, Diez Lopez, I, Ramirez Fernandez, J, Bermudez de la Vega, JA, Yeste Fernandez, D, et al. Adherence and long-term outcomes of growth hormone therapy with easypod in pediatric subjects: Spanish ECOS study. Endocr Connect 2019;8:1240\u20139. https:\/\/doi.org\/10.1530\/ec-19-0325.","DOI":"10.1530\/EC-19-0325"},{"key":"2023040101122168984_j_jpem-2019-0438_ref_038_w2aab3b7c10b1b6b1ab2b2c38Aa","doi-asserted-by":"crossref","unstructured":"Oyarzabal, M, Aliaga, M, Chueca, M, Echarte, G, Ulied, A. Multicentre survey on compliance with growth hormone therapy: what can be improved?. Acta Paediatr 1998;87: 387\u201391. https:\/\/doi.org\/10.1111\/j.1651-2227.1998.tb01464.x.","DOI":"10.1111\/j.1651-2227.1998.tb01464.x"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/jpem\/ahead-of-print\/article-10.1515-jpem-2019-0438\/article-10.1515-jpem-2019-0438.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2019-0438\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2019-0438\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T18:55:59Z","timestamp":1680375359000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2019-0438\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,1]]},"references-count":38,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7,8]]},"published-print":{"date-parts":[[2020,7,28]]}},"alternative-id":["10.1515\/jpem-2019-0438"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2019-0438","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7,1]]}}}