{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:28:03Z","timestamp":1762918083474},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2019-0458_s_999_w2aab3b7c45b1b6b1aab1c15b1Aa\">\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>According to the current classification of the Lawson Wilkins Pediatric Endocrine Society (LWPES) and the European Society for Pediatric Endocrinology (ESPE) of Disorders of Sex Development (DSD), etiologies vary around the world. Ethnic or genetic diversity probably explains this variability. We therefore conducted the present study on etiologies of DSDs in a country from central Africa.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0458_s_998_w2aab3b7c45b1b6b1aab1c15b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We carried out an observational retrospective study at the Pediatric Endocrinology Unit of the Mother and Child Centre of the Chantal Biya Foundation in Yaounde, Cameroon from May 2013 to December 2019. All patients diagnosed with a DSD were included, and incomplete files excluded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0458_s_997_w2aab3b7c45b1b6b1aab1c15b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We included 80 patients diagnosed with DSD during the study period. The 46,XX DSD were the most frequent in our study population (n\u2009=\u200941, 51.25%), with congenital adrenal hyperplasia (CAH) as the main diagnosis. The 46,XY DSD accounted for 33.75% and sex chromosome DSD group represented 15% of the study population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0458_s_996_w2aab3b7c45b1b6b1aab1c15b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>DSDs are not an exceptional diagnosis in a Sub-Saharan context. 46,XX DSD are the most prevalent diagnosis in our setting. The diagnosis of all these affections is late compared to other centers, justifying advocacy for neonatal screening of DSDs in our context.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2019-0458","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T09:03:21Z","timestamp":1582016601000},"page":"417-423","source":"Crossref","is-referenced-by-count":3,"title":["Observational study of disorders of sex development in Yaounde, Cameroon"],"prefix":"10.1515","volume":"33","author":[{"given":"Suzanne Ngo Um","family":"Sap","sequence":"first","affiliation":[{"name":"Mother and Child Center of the Chantal Biya Foundation of Yaounde , Faculty of Medicine and Biomedical Sciences of the University of Yaounde I , Yaounde , Cameroon , Phone: +237 677594797"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritha","family":"Mbono Betoko","sequence":"additional","affiliation":[{"name":"District Hospital of Nylon, Douala, Faculty of Medicine and Pharmaceutical Sciences of the University of Douala , Douala , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Etoa Etoga","sequence":"additional","affiliation":[{"name":"Central Hospital of Yaounde , Faculty of Medicine and Pharmaceutical Sciences of the University of Douala , Douala , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre Yves","family":"Mure","sequence":"additional","affiliation":[{"name":"Hospices civils de Lyon, H\u00f4pital Femme M\u00e8re Enfant, Chirurgie P\u00e9diatrique , Lyon , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Morel","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, GH Est, Centre de Biologie et Pathologie , Lyon , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Dahoun","sequence":"additional","affiliation":[{"name":"Department of Genetics, University Hospital of Geneva , Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faustin","family":"Mouafo Tambo","sequence":"additional","affiliation":[{"name":"Gyneco-Obstetric Hospital of Yaounde , Faculty of Medicine and Biomedical Sciences of the University of Yaounde I , Yaounde , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boniface","family":"Moiffo","sequence":"additional","affiliation":[{"name":"Gyneco-Obstetric Hospital of Yaounde , Faculty of Medicine and Biomedical Sciences of the University of Yaounde I , Yaounde , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eug\u00e8ne","family":"Sobngwi","sequence":"additional","affiliation":[{"name":"Central Hospital of Yaounde , Faculty of medicine and biomedical sciences of the University of Yaounde I , Yaounde , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Koki Ndombo","sequence":"additional","affiliation":[{"name":"Mother and Child Center of the Chantal Biya Foundation Yaounde, Faculty of Medicine and Biomedical Sciences, Department of Paediatrics , Yaounde , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"2023040101053352749_j_jpem-2019-0458_ref_001_w2aab3b7c45b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Hughes IA. 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