{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:13:49Z","timestamp":1791486829762,"version":"4.3.4"},"reference-count":46,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2019-0461_s_999_w2aab3b7c48b1b6b1aab1c15b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>To determine the incidence of congenital hypothyroidism (CH) with a delayed increase in thyroid-stimulating hormone (TSH) levels in preterm infants and to describe the associated factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0461_s_998_w2aab3b7c48b1b6b1aab1c15b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A prospective newborn screening (NBS) was conducted in 122 very low birth weight (VLBW) premature neonates born between June 2016 and September 2017. A dried blood spot thyroid stimulating hormone (TSH) level \u226515 mIU\/L at 7 and 15 days of life, \u226510 in serum at the second screen or \u22655 at the third screen was defined as positive for CH. A concomitant increase in the TSH level and normal free thyroxine (T4) level was classified as hyperthyrotropinemia (HT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0461_s_997_w2aab3b7c48b1b6b1aab1c15b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Before the first month of life, no cases of CH were identified. However, the second and third NBS identified 10 and six subjects with HT, respectively, but no cases of CH. The overall cumulative incidence of HT was 1:8. Small for gestational age (SGA) was a variable that was significantly associated with HT, even after the exclusion of patients with Down syndrome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0461_s_996_w2aab3b7c48b1b6b1aab1c15b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A high incidence of HT, but not CH, was found after the first month of life in preterm infants. Being SGA was strongly associated with having higher TSH. The need for repeating TSH screening after the first month of life in this population remains to be established.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2019-0461","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T09:03:21Z","timestamp":1582016601000},"page":"375-382","source":"Crossref","is-referenced-by-count":18,"title":["Hyperthyrotropinemia is common in preterm infants who are born small for gestational age"],"prefix":"10.1515","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7685-9311","authenticated-orcid":false,"given":"Francisca","family":"Grob","sequence":"first","affiliation":[{"name":"Pontificia Universidad Cat\u00f3lica de Chile , Faculty of Medicine, School of Medicine, Pediatrics Division , Diagonal Paraguay 362, Piso 8 , Santiago 8330074 , Chile , Phone: +56-223549088, Fax: +56-226384307"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monserrat","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Cat\u00f3lica de Chile , Faculty of Medicine, School of Medicine, Pediatrics Division , Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Leguizam\u00f3n","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Cat\u00f3lica de Chile , Faculty of Medicine, School of Medicine, Department of Neonatology , Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Fabres","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Cat\u00f3lica de Chile , Faculty of Medicine, School of Medicine, Department of Neonatology , Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"2023040101053372024_j_jpem-2019-0461_ref_001_w2aab3b7c48b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Ford G, Lafranchi SH. 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