{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:45:26Z","timestamp":1787496326597,"version":"build-2736575974"},"reference-count":70,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,26]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Oxidative stress is implicated in both, the onset and the progression of type 1 diabetes mellitus (T1DM). There is accumulated evidence of increased biomarkers of oxidative stress in newly diagnosed, T1DM patients without complications, and in those with advanced disease. In this cross-sectional study, we investigated factors affecting oxidative stress status in pediatric patients with T1DM.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Advanced oxidation protein products (AOPP), prooxidant-antioxidant balance (PAB), total sulfhydryl (SH) groups, and superoxide dismutase (SOD) activity were determined in 170 children and adolescents with T1DM. Principal component analysis was used to investigate clustering of clinical and laboratory variables associated with elevated oxidative stress and reduced antioxidative defense biomarkers.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Factor analysis extracted five factors, interpreted as (1) \u201cweight status factor\u201d including age, BMI, waist and hip circumferences; (2) \u201cproatherogenic factor\u201d that included LDL-cholesterol, non-HDL-cholesterol, and triglycerides; (3) \u201cmetabolic control factor\u201d including glucose and HbA\n 1c<\/jats:sub>\n ; (4) \u201crenal marker factor\u201d with positive loading of urinary albumin excretion rate and negative loading of GFR; and (5) \u201cantiatherogenic factor\u201d that included HDL-cholesterol. High AOPP levels were independently predicted by \u201cproatherogenic\u201d (OR: 2.32; 95% CI: 1.44\u20133.71; p\u2009<\u20090.001), \u201cmetabolic control\u201d (OR: 2.24; 95% CI: 1.35\u20133.73; p\u2009<\u20090.01), and \u201crenal marker\u201d (OR: 1.65; 95% CI: 1.03\u20132.65; p\u2009<\u20090.05) factors. \u201cRenal marker factor\u201d was a significant predictor of PAB (OR: 0.52; 95% CI: 0.34\u20130.81; p\u2009<\u20090.01). Regarding antioxidative defense markers, reduced SH groups were predicted by \u201cproatherogenic factor\u201d (OR: 0.56; 95% CI: 0.34\u20130.94; p\u2009<\u20090.05), while \u201cweight status factor\u201d predicted lower SOD activity (OR: 1.66; 95% CI: 1.03\u20132.67; p\u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Cardiometabolic risk factors and renal function are associated with oxidative stress in pediatric T1DM patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/jpem-2019-0555","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T10:13:42Z","timestamp":1585649622000},"page":"591-598","source":"Crossref","is-referenced-by-count":7,"title":["Factors associated with oxidative stress status in pediatric patients with type 1 diabetes mellitus"],"prefix":"10.1515","volume":"33","author":[{"given":"Dragana","family":"Kacarevic","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasa","family":"Bogavac-Stanojevic","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Spasojevic-Kalimanovska","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Bojanin","sequence":"additional","affiliation":[{"name":"Biochemical Laboratory, Department for Clinical Chemistry and Hematology, Mother and Child Health Care Institute of Serbia \u201cDr Vukan \u010cupi\u0107\u201d, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Milenkovic","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Mother and Child Health Care Institute of Serbia \u201cDr Vukan \u010cupi\u0107\u201d, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Stefanovic","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Mihajlovic","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Vujcic","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, P. Box 146, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rade","family":"Vukovic","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Mother and Child Health Care Institute of Serbia \u201cDr Vukan \u010cupi\u0107\u201d, Belgrade, Serbia"},{"name":"School of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Zeljkovic","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sladjana","family":"Todorovic","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Mother and Child Health Care Institute of Serbia \u201cDr Vukan \u010cupi\u0107\u201d, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Mitrovic","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Mother and Child Health Care Institute of Serbia \u201cDr Vukan \u010cupi\u0107\u201d, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Vekic","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref411","doi-asserted-by":"crossref","first-page":"21525","DOI":"10.3390\/ijms141121525","article-title":"Oxidative stress in diabetes: implications for vascular and other complications","volume":"14","year":"2013","journal-title":"Int J Mol Sci"},{"key":"ref41","first-page":"11","article-title":"Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses 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