{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:20:22Z","timestamp":1779924022923,"version":"3.53.1"},"reference-count":10,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2019-0565_abs_001_w2aab3b7c29b1b6b1aab1c16b2Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Congenital hyperinsulinism (CH) is the most frequent cause of persistent hypoglycemia in the newborn. Octreotide, a long-acting somatostatin receptor analog (SSRA), is a second line treatment for diazoxide unresponsive CH patients. Although it has been found to be a safe and effective treatment, long-term benefits and side effects, have not been thoroughly evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0565_abs_002_w2aab3b7c29b1b6b1aab1c16b3Aa\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>Some authors have indicated that exocrine pancreatic insufficiency (EPI) is a common but under-recognized adverse reaction in adults treated with octreotide. However, no pediatric patient with SSRA-induced EPI has been reported to date. Here we report a case of an infant with diazoxide unresponsive, diffuse CH, caused by a heterozygous pathogenic paternally inherited mutation in the <jats:italic>ABCC8<\/jats:italic> gene (NM_000352.4:c.357del), that developed exocrine pancreatic insufficiency and secondary vitamin K deficiency associated to chronic octreotide therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0565_abs_003_w2aab3b7c29b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We point out the atypical clinical onset with a cutaneous hemorrhagic syndrome, emphasizing the clinical relevance of this potential side effect.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2019-0565","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T12:57:25Z","timestamp":1594385845000},"page":"947-950","source":"Crossref","is-referenced-by-count":7,"title":["Octreotide-related exocrine pancreatic insufficiency (EPI) in congenital hyperinsulinism"],"prefix":"10.1515","volume":"33","author":[{"given":"Purificaci\u00f3n","family":"Ros-P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Pediatrics , Hospital Universitario Puerta de Hierro-Majadahonda , Madrid , Spain"},{"name":"Department of Pediatrics , Universidad Aut\u00f3noma de Madrid , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz","family":"Golmayo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Hospital Universitario Puerta de Hierro-Majadahonda , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda L.","family":"Cilleruelo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Hospital Universitario Puerta de Hierro-Majadahonda , Madrid , Spain"},{"name":"Department of Pediatrics , Universidad Aut\u00f3noma de Madrid , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Hospital Universitario Puerta de Hierro-Majadahonda , Madrid , Spain"},{"name":"Department of Pediatrics , Universidad Aut\u00f3noma de Madrid , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Celaya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Hospital Universitario Puerta de Hierro-Majadahonda , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Lac\u00e1mara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Hospital Universitario Puerta de Hierro-Majadahonda , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"Mart\u00ednez-Bad\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Hospital Universitario Puerta de Hierro-Majadahonda , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"G\u00fcemes","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Hospital Infantil Universitario Ni\u00f1o Jes\u00fas , Madrid , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de obesidad y nutrici\u00f3n (CIBEROBN), Instituto de Salud Carlos III , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Argente","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Universidad Aut\u00f3noma de Madrid , Madrid , Spain"},{"name":"Department of Endocrinology , Hospital Infantil Universitario Ni\u00f1o Jes\u00fas , Madrid , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de obesidad y nutrici\u00f3n (CIBEROBN), Instituto de Salud Carlos III , Madrid , Spain"},{"name":"Instituto de Investigaci\u00f3n la Princesa , Madrid , Spain"},{"name":"IMDEA Food Institute, Campus of International Excellence (CEI) UAM + CSIC , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,7,8]]},"reference":[{"key":"2023040101122155856_j_jpem-2019-0565_ref_001_w2aab3b7c29b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Kostopoulou, E, Shah, P. 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