{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:57:40Z","timestamp":1784836660226,"version":"3.55.0"},"reference-count":38,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2019-0577_abs_001_w2aab3b7c55b1b6b1aab1c15b2Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Data on the predictive values of parameters included in the diagnostic work-up for precocious puberty (PP) remain limited. We detected the diagnostic value of basal sex hormone levels, pelvic ultrasound parameters and bone age assessment for activation of the hypothalamic-pituitary-gonadal axis in girls with PP, in order to help in the decision to perform GnRH testing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0577_abs_002_w2aab3b7c55b1b6b1aab1c15b3Aa\">\n                  <jats:title>Patients and methods<\/jats:title>\n                  <jats:p>We retrospectively considered 177 girls with PP. According to puberty evolution, the girls were divided into two groups: rapid progressive central precocious puberty (RP-CPP) and non\/slowly progressive\/transient forms (SP-PP). In all patients we considered Tanner stage, basal luteinizing hormone (LH) and estradiol (E2) values, bone age, and pelvis examination. We assessed the diagnostic value of each variable and identified the number of pathological parameters that best identify patients with RP-CPP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0577_abs_003_w2aab3b7c55b1b6b1aab1c15b4Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Basal LH\u00a0\u2265\u00a00.2IU\/L, E2 level \u2265 50\u00a0pmol\/L, uterine longitudinal diameter \u2265\u00a03.5\u00a0cm, transverse uterine diameter \u2265\u00a01.5\u00a0cm, endometrial echo and ovarian volume \u2265\u00a02\u00a0cm<jats:sup>3<\/jats:sup> were significantly associated with RP-CPP (p\u00a0\u2264\u00a00.01). The ability to diagnose RP-CPP was enhanced with increasing number of pathological hormonal and instrumental parameters (p\u00a0&lt;\u00a00.001). With more than three parameters detected, sensitivity and specificity reached 58% (95%CI 48\u201367) and 85% (95%CI 74\u201392), respectively, with a PPV\u00a0=\u00a086% (95%CI 76\u201393) and PPN\u00a0=\u00a054% (95%CI 43\u201354); the area under the ROC curve was 0.71 (95%CI 0.65\u20130.78).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0577_abs_004_w2aab3b7c55b1b6b1aab1c15b5Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Despite the availability of different tests, diagnosing RP-CPP remains difficult. A diagnosis model including at least three hormonal and\/or ultrasound parameters may serve as a useful preliminary step in selecting patients who require GnRH testing for early detection of RC-PP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2019-0577","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T16:36:58Z","timestamp":1590511018000},"page":"785-791","source":"Crossref","is-referenced-by-count":39,"title":["Rapid progressive central precocious puberty: diagnostic and predictive value of basal sex hormone levels and pelvic ultrasound"],"prefix":"10.1515","volume":"33","author":[{"given":"Valeria","family":"Calcaterra","sequence":"first","affiliation":[{"name":"Department of Maternal and Children\u2019s Health, Pediatric Endocinology Unit , Fondazione IRCCS Policlinico S. Matteo and University of Pavia , P.le Golgi n.2 , 27100 , Pavia , Italy"},{"name":"Department of Internal Medicine, Pediatric and Adolescent Unit , University of Pavia , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Klersy","sequence":"additional","affiliation":[{"name":"Biometry & Clinical Epidemiology, Scientific Direction, Fondazione IRCCS Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Vinci","sequence":"additional","affiliation":[{"name":"Pediatric and Adolescent Unit, Department of Internal Medicine , University of Pavia , Pavia , Italy"},{"name":"Pediatric Endocrinology Unit, Department of Maternal and Children\u2019s Health , Fondazione IRCCS Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Regalbuto","sequence":"additional","affiliation":[{"name":"Pediatric and Adolescent Unit, Department of Internal Medicine , University of Pavia , Pavia , Italy"},{"name":"Pediatric Endocrinology Unit, Department of Maternal and Children\u2019s Health , Fondazione IRCCS Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Dobbiani","sequence":"additional","affiliation":[{"name":"Pediatric and Adolescent Unit, Department of Internal Medicine , University of Pavia , Pavia , Italy"},{"name":"Pediatric Endocrinology Unit, Department of Maternal and Children\u2019s Health , Fondazione IRCCS Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Montalbano","sequence":"additional","affiliation":[{"name":"Pediatric and Adolescent Unit, Department of Internal Medicine , University of Pavia , Pavia , Italy"},{"name":"Pediatric Endocrinology Unit, Department of Maternal and Children\u2019s Health , Fondazione IRCCS Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Pelizzo","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit, Ospedale dei Bambini \u201cVittore Buzzi\u201d and Department of Biomedical and Clinical Science \u201cL. Sacco\u201d , University of Milano , Milano , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Albertini","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Chemistry , Fondazione IRCCS Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Larizza","sequence":"additional","affiliation":[{"name":"Pediatric and Adolescent Unit, Department of Internal Medicine , University of Pavia , Pavia , Italy"},{"name":"Pediatric Endocrinology Unit, Department of Maternal and Children\u2019s Health , Fondazione IRCCS Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,5,22]]},"reference":[{"key":"2023040101344813360_j_jpem-2019-0577_ref_001_w2aab3b7c55b1b6b1ab2b2b1Aa","unstructured":"Grumbach MM, Styne DM. Puberty: ontogeny, neuroendocrinology, physiology, and disorders. 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