{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:50:19Z","timestamp":1747198219980,"version":"3.40.5"},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2019-0588_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Patients with type-1 diabetes mellitus (T1DM) and celiac disease (CeD) share the same genetic susceptibility alleles. The diabetes-associated autoantibodies (DAA) may be detected in CeD patients. The aim of this study is to describe the prevalence of DAA in children with CeD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0588_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a cross-sectional study of children with CeD. The CeD patients were divided into two groups; group 1 (n=23) included patients with isolated CeD and group 2 included patients with combined T1DM and CeD. The study was conducted at King Abdulaziz University Hospital (KAUH) in 2012\u20132014. DAA, including glutamic acid decarboxylase antibodies (GADA) and protein tyrosine phosphatase-2 antibodies (IA-2), were measured by enzyme-linked immunosorbent assay (ELISA) in both groups. Clinical, demographic, and laboratory data were collected from the patients\u2019 medical charts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0588_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>DAA were determined in 23 patients in group-1 and 18 patients in group-2. Group-1 comprised 43.5% males and 56.5% females; the mean age was 15\u00a0\u00b1\u00a03.7 years (with a range of 5\u201318 years). The prevalence of GADA and IA-2 was 69.6 and 4%, respectively. Group-2 comprised 55.6% males and 44.4% females; the mean age was 15.1\u00a0\u00b1\u00a02.8 years (with a range of 7\u201318 years). The prevalence of GADA and IA-2 was 66.7 and 22.2%, respectively. No significant differences were found between both groups in the prevalence of GADA (p=1.0) or IA-2 (p=0.15).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0588_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Saudi children with CeD have higher prevalence of GADA than reported in a number of other Western studies. Long-term follow-up data is required before recommending routine screening for DAA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2019-0588","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T12:58:22Z","timestamp":1594385902000},"page":"1009-1012","source":"Crossref","is-referenced-by-count":0,"title":["Saudi children with celiac disease: are they at risk of developing type-1 diabetes mellitus?"],"prefix":"10.1515","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3744-9907","authenticated-orcid":false,"given":"Omar I.","family":"Saadah","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology Unit, Department of Pediatrics, Faculty of Medicine , King Abdulaziz University , Jeddah , Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameera S.","family":"ALsaiari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , King Abdullah Medical Complex , Jeddah , Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamil A.","family":"Al-Mughales","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, Faculty of Medicine , King Abdulaziz University , Jeddah , Saudi Arabia"},{"name":"Department of Clinical Laboratory Medicine and Diagnostic Immunology , King Abdulaziz University Hospital , Jeddah , Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,7,5]]},"reference":[{"key":"2021082202005785975_j_jpem-2019-0588_ref_001","doi-asserted-by":"crossref","unstructured":"Husby, S, Koletzko, S, Korponay-Szabo, IR, Mearin, ML, Phillips, A, Shamir, R, et al. 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