{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T03:59:01Z","timestamp":1754020741110,"version":"3.37.3"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec id=\"j_jpem-2020-0123_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The main cause of hyperandrogenism in children is congenital adrenal hyperplasia, adrenal and gonadal tumors, polycystic ovary syndrome (PCOs) and Cushing\u2019s disease. In the last 20 years several descriptions of girls with hyperandrogenism and venous porto-systemic shunts appeared in literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0123_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>First case is an eleven and a half-year-old girl, was admitted to Department of Endocrinology because of symptoms of hyperandrogenism. Laboratory tests revealed high serum testosterone, androstenedione, and dehydroepiandrosterone sulfate (DHEAS). The ammonia concentration was also increased. In the abdominal angio-CT scans persistent umbilical vein which connected portal and femoral vein was found. The second case was a seven-year-old boy with symptoms of precocious puberty. Blood tests also revealed high concentration of testosterone, androstenedione, DHEAS and ammonia. Imaging studies showed persistent ductus venosus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0123_abs_003\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Although pathophysiological relation is not clear, porto-systemic shunts should be considered as a cause of hyperandrogenism of unknown origin in children.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2020-0123","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T12:32:41Z","timestamp":1594643561000},"page":"1105-1109","source":"Crossref","is-referenced-by-count":1,"title":["Porto-systemic shunt \u2013\u00a0a rare cause of hyperandrogenism in children. Two case reports and review of literature"],"prefix":"10.1515","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0545-1391","authenticated-orcid":false,"given":"Miko\u0142aj","family":"Danko","sequence":"first","affiliation":[{"name":"Department of Paediatric Endocrinology and Diabetology , The Children\u2019s Memorial Health Institute , Warsaw , Poland"},{"name":"Department of Paediatrics, Nutrition and Metabolic Diseases , The Children\u2019s Memorial Health Institute , Warsaw , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Malinowska","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology and Diabetology , The Children\u2019s Memorial Health Institute , Warsaw , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Moszczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology and Diabetology , The Children\u2019s Memorial Health Institute , Warsaw , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Paw\u0142owska","sequence":"additional","affiliation":[{"name":"Department of Gastrology, Hepatology and Feeding Disorders , The Children\u2019s Memorial Health Institute , Warsaw , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Szarras-Czapnik","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology and Diabetology , The Children\u2019s Memorial Health Institute , Warsaw , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Walewska-Wolf","sequence":"additional","affiliation":[{"name":"Outpatient Paediatric Gynecology Clinic , The Children\u2019s Memorial Health Institute , Warsaw , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urszula","family":"W\u0105trobi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology and Diabetology , The Children\u2019s Memorial Health Institute , Warsaw , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mieczys\u0142aw","family":"Szalecki","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology and Diabetology , The Children\u2019s Memorial Health Institute , Warsaw , Poland"},{"name":"Collegium Medicum , Jan Kochanowski University , Kielce , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,7,11]]},"reference":[{"key":"2021082202005792301_j_jpem-2020-0123_ref_001","doi-asserted-by":"crossref","unstructured":"Ghizzoni, L, Mastorakos, G, Vottero, A. 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