{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T06:06:29Z","timestamp":1743401189392,"version":"3.37.3"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"11","funder":[{"name":"The Department of Pediatrics Clinical Center of Suzhou","award":["Szzx201504"],"award-info":[{"award-number":["Szzx201504"]}]},{"name":"Suzhou Personnel Planning Project","award":["GSWS2019051"],"award-info":[{"award-number":["GSWS2019051"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700793"],"award-info":[{"award-number":["81700793"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2020-0158_abs_001_w2aab3b7c27b1b6b1aab1c17b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Graves\u2019 disease (GD) is an autoimmune disease involving intimate response of both T\u00a0cells and B\u00a0cells. Immunophenotyping of peripheral blood lymphocyte subsets in GD children with different clinical characteristics can provide further information of the pathogenesis of GD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0158_abs_002_w2aab3b7c27b1b6b1aab1c17b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We studied the lymphocyte subsets in peripheral blood of 141 children with GD. We repeatedly divided the patients into two groups in accordance with different clinical characteristics (abnormal or normal alanine aminotransferase (ALT) levels, the presence or absence of Graves\u2019 orbitopathy (GO), and the presence or absence of hematuria. Then we compared the lymphocyte subsets measurements between two paired groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0158_abs_003_w2aab3b7c27b1b6b1aab1c17b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found that serum ALT levels correlated positively with CD3+CD8+ T\u00a0cell percentages in children with GD. Moreover, we detected higher percentages of CD3\u2212CD19+ cells and higher ratio of CD4\/CD8 in patients with GO. However, no correlation was found between GO status and lymphocyte subsets after excluding confounding effect of TRAb. No difference of lymphocyte subset percentages was found between groups with or without hematuria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0158_abs_004_w2aab3b7c27b1b6b1aab1c17b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Serum ALT levels correlate positively with cytotoxic T\u00a0cell percentages in the peripheral blood of children with GD. The cytotoxic T\u00a0cell may play a role in the pathogenesis of hepatic dysfunction in children with GD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2020-0158","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T18:42:19Z","timestamp":1597689739000},"page":"1425-1430","source":"Crossref","is-referenced-by-count":8,"title":["Clinical relevance of T lymphocyte subsets in pediatric Graves\u2019 disease"],"prefix":"10.1515","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0179-3586","authenticated-orcid":false,"given":"Ting","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism , Children\u2019s Hospital of Soochow University , Suzhou , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism , Children\u2019s Hospital of Soochow University , Suzhou , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haojie","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism , Children\u2019s Hospital of Soochow University , Suzhou , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuli","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism , Children\u2019s Hospital of Soochow University , Suzhou , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongrong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism , Children\u2019s Hospital of Soochow University , Suzhou , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism , Children\u2019s Hospital of Soochow University , Suzhou , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism , Children\u2019s Hospital of Soochow University , Suzhou , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism , Children\u2019s Hospital of Soochow University , Suzhou , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism , Children\u2019s Hospital of Soochow University , Suzhou , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism , Children\u2019s Hospital of Soochow University , Suzhou , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism , Children\u2019s Hospital of Soochow University , Suzhou , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"2023040101055745206_j_jpem-2020-0158_ref_001_w2aab3b7c27b1b6b1ab2b1b1Aa","unstructured":"NB SET, McArthur, JW, Crawford, JD. 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